Adefovir Impurities

Adefovir is used to treat chronic (long-term) hepatitis B infection (viral-caused liver swelling).

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Parent Drug Name Name of Impurity Catalogue No.
ADEFOVIR Adefovir Dipivoxil VE0012003View CAS 142340-99-6
Adefovir Adefovir Dipivoxil Impurity 1 VL5400021View CAS 1215101-40-8
Adefovir Adefovir Dipivoxil Impurity 10 VL5400009View CAS 1875153-79-9
ADEFOVIR Adefovir Dipivoxil Impurity 2 VE0012009View CAS 1416439-02-5
ADEFOVIR Adefovir Dipivoxil Impurity 3 VE0011998View CAS 323201-06-5
ADEFOVIR Adefovir Dipivoxyl Impurity C VE0012007View CAS 142341-04-6
Adefovir Adefovir Dipivoxyl Impurity I VL5400020View
Adefovir Adefovir Disoproxil Dimer Impurity VE009375View CAS 323201-05-4
Adefovir Adefovir Monopivoxil VL5400023View CAS 142341-05-7

Adefovir Related Compound

Adefovir belongs to the class of drugs known as nucleotide analogs. It works by lowering the level of the hepatitis B virus (HBV) in the body.

References

  • “Adefovir: MedlinePlus Drug Information.” Medlineplus.gov, 2018, medlineplus.gov/drug info/meds/a605024.html#:~:text=Adefovir%20is%20in%20a%20class,(HBV)%20in%20the%20body. Accessed 17 June 2023.
  • ‌“Adefovir Dipivoxil: Uses, Interactions, Mechanism of Action | DrugBank Online.” Drugbank.com, DrugBank, 2016, go.drugbank.com/drugs/DB00718. Accessed 17 June 2023.
  • ‌PubChem. “Adefovir.” @Pubchem, PubChem, 2023, pubchem.ncbi.nlm.nih.gov/compound/Adefovir. Accessed 17 June 2023.

FAQ

Adefovir belongs to which class of drug?

Adefovir belongs to a group of drugs known as nucleotide analogs. It works by lowering the level of the hepatitis B virus (HBV) in the body.

What is the mechanism of action of adefovir?

By competing with the natural substrate deoxyadenosine triphosphate and inducing DNA chain termination following inclusion into viral DNA, adefovir diphosphate inhibits HBV DNA polymerase (reverse transcriptase).

What is the clinical use of adefovir?

Adefovir, a phosphonic acid that belongs to the methylphosphonic acid group, is used to treat chronic hepatitis B virus infection. It is an inhibitor of HIV-1 reverse transcriptase. It acts as an HIV-1 reverse transcriptase inhibitor, drug metabolite, antiviral agent, nephrotoxic agent, and DNA synthesis inhibitor.

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1215101-40-8: Adefovir Dipivoxil Impurity 1

1215101-40-8: Adefovir Dipivoxil Impurity 1
Catalogue No.

VL5400021

CAS No.

1215101-40-8

Molecular Formula

C25H40N5O8P

Molecular Weight

569.58 g/mol

Parent drug

Adefovir

IUPAC Name

((((2-(6-pivalamido-9H-purin-9-yl)ethoxy)methyl)phosphinediyl)bis(oxy))bis(methylene) bis(2, 2-dimethylpropanoate)

Synonyms

N/A

References

Gao, Yuan, et al. “Coformer Selection Based on Degradation Pathway of Drugs: A Case Study of Adefovir Dipivoxil–Saccharin and Adefovir Dipivoxil–Nicotinamide Cocrystals.” International Journal of Pharmaceutics, vol. 438, no. 1-2, Nov. 2012, pp. 327–35, https://doi.org/10.1016/j.ijpharm.2012.09.027. Yuan, Lung-Chi. Pharmaceutical Research, vol. 17, no. 9, 2000, pp. 1098–103, https://doi.org/10.1023/a:1026457729708.

Status

In-stock

ListName

Adefovir Dipivoxil Impurity 1

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