| Parent Drug Name | Name of Impurity | Catalogue No. | |
|---|---|---|---|
| Aflatoxin | Aflatoxin B1 | VL5520002 | View CAS 1162-65-8 |
| Aflatoxin | Aflatoxin B2 | VL5520003 | View CAS 7220-81-7 |
| Aflatoxin | Aflatoxin M2 | VL5520001 | View CAS 6885-57-0 |
Aflatoxin Related Compound
Aspergillus flavus and Aspergillus parasitics create aflatoxins, which are secondary adverse fungal metabolites.
References
- Arai, Tadashi, et al. Antimicrobial Activity of Aflatoxins. no. 1, Jan. 1967, pp. 59–64, https://doi.org/10.1128/jb.93.1.59-64.1967. Accessed 21 June 2023.
- Nadia Ameen Abdulmajeed. Therapeutic Ability of Some Plant Extracts on Aflatoxin B1 Induced Renal and Cardiac Damage. no. 1, Jan. 2011, pp. 1–10, https://doi.org/10.1016/j.arabjc.2010.06.005. Accessed 21 June 2023.
FAQ
What is the function of aflatoxins?
Aflatoxins attack the liver’s immune system, kidneys, and other organs. The most powerful naturally occurring carcinogen is aflatoxin B1. The metabolism of AFs differs between species, which presumably explains the variability in toxicity. AF metabolites that are reactive form adducts with nucleic acids and proteins.
Is aflatoxin an antibiotic?
Antibacterial activity against numerous species of Streptomyces and Nocardia, but restricted and limited. N among seven microorganism strains, including aflatoxin-sensitive and -resistant strains.
What is the mechanism of action of aflatoxins?
Aflatoxin B1, a genotoxic hepatocarcinogen, is thought to induce cancer by producing DNA adducts that cause genetic alterations in target liver cells. Cytochrome-P450 enzymes metabolize AFB1 to the reactive intermediate AFB1-8, 9 epoxide (AFBO), which attaches to liver cell DNA and forms DNA adducts.
