Aflatoxin impurities

Aflatoxins have been used as mutagens, carcinogens, teratogens, immunosuppressors, and inhibitors of various metabolic systems, causing liver, kidney, and heart damage.

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Impurity structure Parent Drug Name Name of Impurity Catalogue No. CAS No.
Aflatoxin B1 Aflatoxin

Aflatoxin B1

VL5520002 1162-65-8
Aflatoxin B2 Aflatoxin

Aflatoxin B2

VL5520003 7220-81-7
Aflatoxin M2 Aflatoxin

Aflatoxin M2

VL5520001 6885-57-0

Aflatoxin Related Compound

Aspergillus flavus and Aspergillus parasitics create aflatoxins, which are secondary adverse fungal metabolites.

References

FAQ

What is the function of aflatoxins?

Aflatoxins attack the liver’s immune system, kidneys, and other organs. The most powerful naturally occurring carcinogen is aflatoxin B1. The metabolism of AFs differs between species, which presumably explains the variability in toxicity. AF metabolites that are reactive form adducts with nucleic acids and proteins.

Is aflatoxin an antibiotic?

Antibacterial activity against numerous species of Streptomyces and Nocardia, but restricted and limited. N among seven microorganism strains, including aflatoxin-sensitive and -resistant strains.

What is the mechanism of action of aflatoxins?

Aflatoxin B1, a genotoxic hepatocarcinogen, is thought to induce cancer by producing DNA adducts that cause genetic alterations in target liver cells. Cytochrome-P450 enzymes metabolize AFB1 to the reactive intermediate AFB1-8, 9 epoxide (AFBO), which attaches to liver cell DNA and forms DNA adducts.