Aflatoxin impurities

Aflatoxins have been used as mutagens, carcinogens, teratogens, immunosuppressors, and inhibitors of various metabolic systems, causing liver, kidney, and heart damage.

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Parent Drug Name Name of Impurity Catalogue No.
Aflatoxin Aflatoxin B1 VL5520002View CAS 1162-65-8
Aflatoxin Aflatoxin B2 VL5520003View CAS 7220-81-7
Aflatoxin Aflatoxin M2 VL5520001View CAS 6885-57-0

Aflatoxin Related Compound

Aspergillus flavus and Aspergillus parasitics create aflatoxins, which are secondary adverse fungal metabolites.

References

FAQ

What is the function of aflatoxins?

Aflatoxins attack the liver’s immune system, kidneys, and other organs. The most powerful naturally occurring carcinogen is aflatoxin B1. The metabolism of AFs differs between species, which presumably explains the variability in toxicity. AF metabolites that are reactive form adducts with nucleic acids and proteins.

Is aflatoxin an antibiotic?

Antibacterial activity against numerous species of Streptomyces and Nocardia, but restricted and limited. N among seven microorganism strains, including aflatoxin-sensitive and -resistant strains.

What is the mechanism of action of aflatoxins?

Aflatoxin B1, a genotoxic hepatocarcinogen, is thought to induce cancer by producing DNA adducts that cause genetic alterations in target liver cells. Cytochrome-P450 enzymes metabolize AFB1 to the reactive intermediate AFB1-8, 9 epoxide (AFBO), which attaches to liver cell DNA and forms DNA adducts.

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1162-65-8: Aflatoxin B1

1162-65-8: Aflatoxin B1
Catalogue No.

VL5520002

CAS No.

1162-65-8

Molecular Formula

C17H12O6

Molecular Weight

312.28

Parent drug

Aflatoxin

IUPAC Name

(6aR, 9aS)-4-methoxy-3, 3a, 9a, 11a-tetrahydrocyclopenta[c]furo[3', 2':4, 5]furo[2, 3-h]chromene-1, 11(2H, 6aH)-dione

Synonyms

N/A

References

Guengerich, F. Peter., et al. “Activation and Detoxication of Aflatoxin B1.” Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, vol. 402, no. 1-2, June 1998, pp. 121–28,  https://doi.org/10.1016/s0027-5107(97)00289-3.

Status

Under Development

ListName

Aflatoxin B1

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