Alendronate Impurities

Alendronate is used for the treatment of postmenopausal osteoporosis, prevention of postmenopausal osteoporosis, steroid-induced osteoporosis, male osteoporosis, and Paget disease of the bone.

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Impurity structure Parent Drug Name Name of Impurity Catalogue No. CAS No.
Alendronate EP Impurity B Alendronate

Alendronate EP Impurity B

VE007830 14265-44-2
Alendronate EP Impurity C Alendronate

Alendronate EP Impurity C

VE007834 14901-63-4
Alendronate Impurity 1 Alendronate

Alendronate Impurity 1

VL5730006 N/A

Alendronate Related Compound

Alendronate is classified as a bisphosphonate.

References

  • Azuma, Y., et al. Effects of Alendronate on Plasma Calcium Levels, Urinary Calcium Excretion, and Bone Resorption Markers in Normal Rats: Comparison with Elcatonin, Synthetic Eel Calcitonin. no. 6, June 1996, pp. 2586–92, https://doi.org/10.1210/endo.137.6.8641213. Accessed 28 June 2023.
  • ‌Fisher, John, et al. Alendronate Mechanism of Action: Geranylgeraniol, an Intermediate in the Mevalonate Pathway, Prevents Inhibition of Osteoclast Formation, Bone Resorption, and Kinase Activation in Vitro. no. 1, Jan. 1999, pp. 133–38, https://doi.org/10.1073/pnas.96.1.133. Accessed 28 June 2023.

FAQ

Does alendronate promote calcium deficiency?

The results presented indicate that alendronate lowers plasma Ca primarily by limiting bone resorption, whereas elcatonin lowers plasma Ca by blocking bone resorption and increasing Ca excretion.

What is alendronate used for?

Alendronate manages osteoporosis and Paget’s disease of the bones but does not cure them. Alendronate is only effective in treating and preventing osteoporosis when taken on a regular basis.

What is the mechanism of action of alendronate?

It inhibits the formation of GGPP inside osteoclasts by inhibiting an enzyme(s) in the cholesterol biosynthesis pathway, most likely leading to a loss of prenylation of GTP-binding proteins that affect cytoskeletal function, vesicular trafficking, and death.