|Parent Drug Name||Name of Impurity||Catalogue No.|
|Alfacalcidol||Alfacalcidol EP Impurity A||VL5740002||View CAS 65445-14-9|
|Alfacalcidol||Alfacalcidol EP Impurity B||VL5740003||View CAS 63181-13-5|
|Alfacalcidol||Alfacalcidol EP Impurity C||VL5740004||View CAS 82266-85-1|
Alfacalcidol Related Compound
Alfacalcidol is widely utilized in the treatment of osteoporosis, but its mechanism of action in bone remains unknown. Alfacalcidol promotes intestinal calcium (Ca) absorption, increases urine Ca excretion and serum Ca levels, and inhibits PTH release.
- Vervloet, Marc. “Clinical Uses of 1-Alpha-Hydroxycholecalciferol.” Current Vascular Pharmacology, vol. 12, no. 2, Apr. 2014, pp. 300–5, https://doi.org/10.2174/15701611113119990132. It was accessed 20 Feb. 2023.
- Shiraishi, A., et al. “The Advantage of Alfacalcidol over Vitamin D in the Treatment of Osteoporosis.” Calcified Tissue International, vol. 65, no. 4, Oct. 1999, pp. 311–16, https://doi.org/10.1007/s002239900704. Accessed 20 Feb. 2023.
- Landing.” Medicines.org.uk, 2023, www.medicines.org.uk/emc/landing#gref. Accessed 20 Feb. 2023.
Why is alfacalcidol used in renal failure?
Alfacalcidol is a common vitamin D molecule, particularly in clinical nephrology, since it does not require enzymatic activation by the kidneys. As a result, it has been used for decades to address anomalies in bone and mineral balance that occur in chronic renal disease.
Alfacalcidol belongs to what category of drugs?
One-Alpha includes the active ingredient alfacalcidol. One-Alpha belongs to a class of drugs known as vitamin D analogs. It’s a type of vitamin D.
What is alfacalcidol's mechanism of action?
Alfacalcidol promotes intestinal calcium (Ca) absorption, increases urine Ca excretion and serum Ca levels, and inhibits PTH release.