|Parent Drug Name||Name of Impurity||Catalogue No.|
|Allylamine||Allylamine HCl||VL5850001||View CAS 10017-11-5|
|Allylamine||Polyallylamine Hydrochloride||VL5850002||View CAS 71550-12-4|
Allylamine Related Compound
Allylamine antifungals are used to destroy fungi in order to cure athlete’s foot, jock itch, ringworm, and nail fungus. They function by preventing fungal development.
- Birnbaum, Jay E. “Pharmacology of the Allylamines.” Journal of the American Academy of Dermatology, vol. 23, no. 4, Oct. 1990, pp. 782–85, https://doi.org/10.1016/0190-9622(90)70288-s. Accessed 8 Feb. 2023.
- Mercer, Melissa A. “Allylamines for Use in Animals.” MSD Veterinary Manual, MSD Veterinary Manual, 5 Aug. 2022, www.msdvetmanual.com/pharmacology/antifungal-agents/allylamines-for-use-in-animals#:~:text=Allylamines%20are%20fungicidal%2C%20and%20their,depletion%20in%20the%20cell%20membrane. Accessed 8 Feb. 2023.
- Allylamine Antifungal | DrugBank Online.” Drugbank.com, DrugBank, 2022, go.drugbank.com/categories/DBCAT003396. Accessed 8 Feb. 2023.
Is allylamine an antifungal?
Allylamines are an unique class of antifungal medicines that block ergosterol production at the squalene epoxidase level. These drugs have a strong selectivity for the fungal enzyme and have no effect on mammalian cholesterol production.
What is the mechanism of action of allylamines as antifungals?
Allylamines are fungicides with a competitive inhibition of squalene epoxidase that prevents the conversion of squalene to lanosterol, resulting in squalene accumulation and ergosterol depletion in the cell membrane.
What are the clinical uses of allylamines?
An antifungal drug used to treat Tinea, Trichophyton, and Epidermophyton infections. An allylamine antifungal that is used to treat dermatophyte infections of the toes and fingers, as well as other fungal skin diseases.