Alosetron Impurities

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Impurity structure Parent Drug Name Name of Impurity Catalogue No. CAS No.
Alosetron 6-Hydroxy Impurity Alosetron

Alosetron 6-Hydroxy Impurity

VL1730002 128486-89-5
Alosetron 7-Hydroxy Impurity Alosetron

Alosetron 7-Hydroxy Impurity

VL1730014 863485-44-3
Alosetron HCL Impurity D Alosetron

Alosetron HCL Impurity D

VL1730001 N/A
Alosetron N-Desmethyl Impurity Alosetron

Alosetron N-Desmethyl Impurity

VL1730010 122852-63-5
Hydroxymethyl Alosetron Alosetron

Hydroxymethyl Alosetron

VL1730011 863485-46-5
3,4-Didehydro Alosetron Alosetron

3,4-Didehydro Alosetron

VE0012110 122852-86-2

Alosetron Related Compound

Alosetron is prescribed to women who have severe irritable bowel syndrome (IBS) with diarrhea as the primary symptom.

References

  • Scholar, Eric. “Alosetron HCl.” XPharm: The Comprehensive Pharmacology Reference, 2007, pp. 1–4, https://doi.org/10.1016/b978-008055232-3.61189-4. Accessed 13 Feb. 2023.
  • Alosetron: MedlinePlus Drug Information.” Medlineplus.gov, 2018, medlineplus.gov/druginfo/meds/a601230.html#:~:text=Alosetron%20is%20in%20a%20class,bowel%20movements)%20through%20the%20intestines. Accessed 13 Feb. 2023.
  • Butt, Ifrah, and Franklin Kasmin. “Alosetron.” Nih.gov, StatPearls Publishing, 5 Dec. 2022, www.ncbi.nlm.nih.gov/books/NBK553080/. Accessed 13 Feb. 2023.

FAQ’s

Does alosetron boost intestinal activity?

Alosetron is a 5-HT-3 (5-hydroxytryptamine or serotonin type 3) receptor antagonist that inhibits GI tract neurons, reducing intestinal secretion, motility, and afferent pain signals.

What drug class does alosetron belong to?

Alosetron belongs to a family of drugs known as 5-HT3 receptor antagonists. Alosetron slows the passage of feces (bowel motions) through the intestines.

What is the mechanism of action of Alosetron?

Alosetron is a 5-hydroxytryptamine 3 (5-HT3, serotonin) receptor antagonist that inhibits peristalsis and slows colonic transit time, allowing for greater water reabsorption and more produced stool. [5] [8] Blocking these receptors decreases pain, stomach discomfort, urgency, and diarrhea in IBS-D patients.