Alosetron Impurities

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Parent Drug Name Name of Impurity Catalogue No.
Alosetron Alosetron 6-Hydroxy Impurity VL1730002View CAS 128486-89-5
Alosetron Alosetron 7-Hydroxy Impurity VL1730014View CAS 863485-44-3
Alosetron Alosetron HCL Impurity D VL1730001View
Alosetron Alosetron N-Desmethyl Impurity VL1730010View CAS 122852-63-5
Alosetron Hydroxymethyl Alosetron VL1730011View CAS 863485-46-5

Alosetron Related Compound

Alosetron is prescribed to women who have severe irritable bowel syndrome (IBS) with diarrhea as the primary symptom.

References

  • Scholar, Eric. “Alosetron HCl.” XPharm: The Comprehensive Pharmacology Reference, 2007, pp. 1–4, https://doi.org/10.1016/b978-008055232-3.61189-4. Accessed 13 Feb. 2023.
  • Alosetron: MedlinePlus Drug Information.” Medlineplus.gov, 2018, medlineplus.gov/druginfo/meds/a601230.html#:~:text=Alosetron%20is%20in%20a%20class,bowel%20movements)%20through%20the%20intestines. Accessed 13 Feb. 2023.
  • Butt, Ifrah, and Franklin Kasmin. “Alosetron.” Nih.gov, StatPearls Publishing, 5 Dec. 2022, www.ncbi.nlm.nih.gov/books/NBK553080/. Accessed 13 Feb. 2023.

FAQ’s

Does alosetron boost intestinal activity?

Alosetron is a 5-HT-3 (5-hydroxytryptamine or serotonin type 3) receptor antagonist that inhibits GI tract neurons, reducing intestinal secretion, motility, and afferent pain signals.

What drug class does alosetron belong to?

Alosetron belongs to a family of drugs known as 5-HT3 receptor antagonists. Alosetron slows the passage of feces (bowel motions) through the intestines.

What is the mechanism of action of Alosetron?

Alosetron is a 5-hydroxytryptamine 3 (5-HT3, serotonin) receptor antagonist that inhibits peristalsis and slows colonic transit time, allowing for greater water reabsorption and more produced stool. [5] [8] Blocking these receptors decreases pain, stomach discomfort, urgency, and diarrhea in IBS-D patients.

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122852-63-5: Alosetron N-Desmethyl Impurity

122852-63-5: Alosetron N-Desmethyl Impurity
Catalogue No.

VL1730010

CAS No.

122852-63-5

Molecular Formula

C16H16N4O

Molecular Weight

280.32

Parent drug

Alosetron

IUPAC Name

2, 3, 4, 5-Tetrahydro-2-[(5-methyl-1H-imidazol-4-yl)methyl]-1H-pyrido[4, 3-b]indol-1-one

Synonyms

N/A

References

“Characterization of the Metabolites of Alosetron in Experimental Animals and Human.” Xenobiotica, 2021, http://www.tandfonline.com/doi/abs/10.1080/00498250400028247.

Status

In-stock

ListName

Alosetron N-Desmethyl Impurity

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