Althiazide Impurities

Altizide, a thiazide diuretic and aldosterone antagonist, was marketed as Aldactazine in conjunction with spironolactone to treat patients with mild to moderate hypertension.

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Impurity structure Parent Drug Name Name of Impurity Catalogue No. CAS No.
Altizide EP Impurity A Althiazide

Altizide EP Impurity A

VL5940002 121-30-2
Altizide EP Impurity B Althiazide

Altizide EP Impurity B

VL5940003 84522-35-0

Althiazide Related Compound

Aldactazine was also studied for the treatment of congestive heart insufficiency.



What is the mechanism of action of althiazide ?

If dietary Na+ is reduced at the commencement of therapy, diuretics’ early impact to lower ECF volume is enhanced. This reduces the effects of the braking phenomenon, which is typical with long-term diuretic usage. 7 Some restriction in dietary Na+ intake may also be important to how diuretics persistently affect TPR. The initial volume contraction seen during the first few days of althiazide diuretic medication is hypothesised to cause changes in Na+/Ca2+ equilibrium in vascular smooth muscle cells.

What is the use of althiazide?

Altizide (Althiazide) is an orallyactive diuretic. Altizide can be used in studies of oedema and hypertension.

Which drug class does althizide belong to?

Althiazide, commonly known as altizide, is a class of thiazide diuretics having antihypertensive action.