Althiazide Impurities

Altizide, a thiazide diuretic and aldosterone antagonist, was marketed as Aldactazine in conjunction with spironolactone to treat patients with mild to moderate hypertension.

veeprho banner
Parent Drug Name Name of Impurity Catalogue No.
Althiazide Altizide EP Impurity A VL5940002View CAS 121-30-2
Althiazide Altizide EP Impurity B VL5940003View CAS 84522-35-0

Althiazide Related Compound

Aldactazine was also studied for the treatment of congestive heart insufficiency.

References

FAQ

What is the mechanism of action of althiazide ?

If dietary Na+ is reduced at the commencement of therapy, diuretics’ early impact to lower ECF volume is enhanced. This reduces the effects of the braking phenomenon, which is typical with long-term diuretic usage. 7 Some restriction in dietary Na+ intake may also be important to how diuretics persistently affect TPR. The initial volume contraction seen during the first few days of althiazide diuretic medication is hypothesised to cause changes in Na+/Ca2+ equilibrium in vascular smooth muscle cells.

What is the use of althiazide?

Altizide (Althiazide) is an orallyactive diuretic. Altizide can be used in studies of oedema and hypertension.

Which drug class does althizide belong to?

Althiazide, commonly known as altizide, is a class of thiazide diuretics having antihypertensive action.

[rfq_list]

Request a quote

121-30-2: Altizide EP Impurity A

121-30-2: Altizide EP Impurity A
Catalogue No.

VL5940002

CAS No.

121-30-2

Molecular Formula

C6H8ClN3O4S2

Molecular Weight

285.73 g/mol

Parent drug

Althiazide

IUPAC Name

4-Amino-6-chlorobenzene-1, 3-disulfonamide

Synonyms

N/A

References

Béranger, C., et al. “[Electrophysiologic Effects of a Spironolactone-Altizide Combination on the Isolated Rat Heart].” Archives Des Maladies Du Coeur et Des Vaisseaux, vol. 79, no. 7, June 1986, pp. 1117–21, europepmc.org/article/med/3096237. Sternon, Jacques. “Spironolactone and Altizide in Systemic Hypertension: Ambulatory Multicenter Study.” The American Journal of Cardiology, vol. 65, no. 23, June 1990, pp. K24–27, https://doi.org/10.1016/0002-9149(90)91273-9.

Status

Under development

ListName

Altizide EP Impurity A

Exclusively Supplied by Veeprho

Exclusively Supplied by Veeprho

"*" indicates required fields

Hidden
Products quotation
Name
Url
 
Hidden