| Parent Drug Name | Name of Impurity | Catalogue No. | |
|---|---|---|---|
| Ambrisentan | Ambrisentan (R)-Isomer | VE007941 | View CAS 1007358-76-0 |
| Ambrisentan | Ambrisentan 4-Hydroxymethyl Analog Racemate | VE007946 | View CAS 1106685-84-0 |
| Ambrisentan | Ambrisentan Acyl Glucuronide (Mixture of Diastereomers) | VL6020010 | View CAS 1106685-82-8 |
| Ambrisentan | Ambrisentan Epoxide Impurity | VE0010843 | View CAS 76527-25-8 |
| Ambrisentan | Ambrisentan Ethyl Ester | VL6020017 | View CAS 1349854-31-4 |
| Ambrisentan | Ambrisentan Ethyl Ester Racemate | VE007947 | View |
| Ambrisentan | Ambrisentan Hydroxy Acid Impurity | VE007958 | View CAS 178306-49-5 |
| Ambrisentan | Ambrisentan Hydroxy Acid Impurity (S-Isomer) | VL6020002 | View CAS 178306-52-0 |
| Ambrisentan | Ambrisentan Hydroxyester Impurity | VL6020003 | View CAS 177036-78-1 |
| Ambrisentan | Ambrisentan Impurity 2 | VL6020007 | View |
| Ambrisentan | Ambrisentan Impurity 9 | VE0012123 | View CAS 178306-51-9 |
| Ambrisentan | Ambrisentan Impurity E | VL6020015 | View CAS 1312092-82-2 |
| Ambrisentan | Ambrisentan Methyl Ester | VL6020018 | View CAS 1106685-61-3 |
| Ambrisentan | Ambrisentan Methyl Ester Racemate | VL6020019 | View CAS 1240470-84-1 |
| Ambrisentan | Ambrisentan N-Oxide | VL6020006 | View |
| Ambrisentan | Ambrisentan Racemate | VL6020020 | View CAS 713516-99-5 |
| Ambrisentan | Ambrisentan Vinyloxy Impurity | VL6020011 | View CAS 1639429-81-4 |
| Ambrisentan | Ambrisentan pyrimidine Ester Impurity | VL6020004 | View |
| Ambrisentan | rac-Ambrisentan-D5 | DVE00140 | View CAS 1392210-85-3 |
| Ambrisentan | 4, 6-Dimethyl-5, 6-dihydropyrimidine-2-(1H)-thione | VE0010841 | View |
| Ambrisentan | 4-Hydroxymethyl Ambrisentan Acyl Beta Glucuronide | VL6020005 | View |
| Ambrisentan | (S)-4-Hydroxymethyl Ambrisentan | VL6020013 | View CAS 1106685-66-8 |
Ambrisentan Related Compound
Ambrisentan is a medication prescribed to treat pulmonary hypertension. The peptide endothelin constricts blood vessel muscles, raising blood pressure.
References
- Ambrisentan (Oral Route) Description and Brand Names – Mayo Clinic.” Mayoclinic.org, 2023, www.mayoclinic.org/drugs-supplements/ambrisentan-oral-route/description/drg-20071118#:~:text=Ambrisentan%20is%20used%20to%20treat,the%20worsening%20of%20your%20condition. Accessed 21 Feb. 2023.
- Ambrisentan: Uses, Interactions, Mechanism of Action | DrugBank Online.” Drugbank.com, DrugBank, 2020, go.drugbank.com/drugs/DB06403. Accessed 21 Feb. 2023.
- Ambrisentan (Letairis) – Side Effects, Interactions, Uses, Dosage, Warnings.” EverydayHealth.com, 23 June 2020, www.everydayhealth.com/drugs/ambrisentan#:~:text=Ambrisentan%20lowers%20blood%20pressure%20in,your%20condition%20from%20getting%20worse. Accessed 21 Feb. 2023.
FAQ
What is ambrisentan used for?
Ambrisentan is used to treat the symptoms of pulmonary arterial hypertension, or high blood pressure in the major artery that carries blood from the right side of the heart (the ventricle) to the lungs, in order to enhance your capacity to exercise and reduce the progression of your illness.
What is the mechanism of action of ambrisentan?
As an endothelin receptor antagonist, Ambrisentan prevents endogenous endothelin peptide from constricting the muscles in blood vessels, allowing them to relax and permitting a reduction in blood pressure.
Does ambrisentan lower BP?
Ambrisentan decreases pulmonary blood pressure, allowing your heart to pump blood more effectively. Adults are treated with ambrisentan for pulmonary arterial hypertension (PAH). It enhances your capacity to exercise and keeps your condition from worsening.
