Ambrisentan Impurities

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Parent Drug Name Name of Impurity Catalogue No.
Ambrisentan Ambrisentan (R)-Isomer VE007941View CAS 1007358-76-0
Ambrisentan Ambrisentan 4-Hydroxymethyl Analog Racemate VE007946View CAS 1106685-84-0
Ambrisentan Ambrisentan Acyl Glucuronide (Mixture of Diastereomers) VL6020010View CAS 1106685-82-8
Ambrisentan Ambrisentan Epoxide Impurity VE0010843View CAS 76527-25-8
Ambrisentan Ambrisentan Ethyl Ester VL6020017View CAS 1349854-31-4
Ambrisentan Ambrisentan Ethyl Ester Racemate VE007947View
Ambrisentan Ambrisentan Hydroxy Acid Impurity VE007958View CAS 178306-49-5
Ambrisentan Ambrisentan Hydroxy Acid Impurity (S-Isomer) VL6020002View CAS 178306-52-0
Ambrisentan Ambrisentan Hydroxyester Impurity VL6020003View CAS 177036-78-1
Ambrisentan Ambrisentan Impurity 2 VL6020007View
Ambrisentan Ambrisentan Impurity 9 VE0012123View CAS 178306-51-9
Ambrisentan Ambrisentan Impurity E VL6020015View CAS 1312092-82-2
Ambrisentan Ambrisentan Methyl Ester VL6020018View CAS 1106685-61-3
Ambrisentan Ambrisentan Methyl Ester Racemate VL6020019View CAS 1240470-84-1
Ambrisentan Ambrisentan N-Oxide VL6020006View
Ambrisentan Ambrisentan Racemate VL6020020View CAS 713516-99-5
Ambrisentan Ambrisentan Vinyloxy Impurity VL6020011View CAS 1639429-81-4
Ambrisentan Ambrisentan pyrimidine Ester Impurity VL6020004View
Ambrisentan rac-Ambrisentan-D5 DVE00140View CAS 1392210-85-3
Ambrisentan 4, 6-Dimethyl-5, 6-dihydropyrimidine-2-(1H)-thione VE0010841View
Ambrisentan 4-Hydroxymethyl Ambrisentan Acyl Beta Glucuronide VL6020005View
Ambrisentan (S)-4-Hydroxymethyl Ambrisentan VL6020013View CAS 1106685-66-8

Ambrisentan Related Compound

Ambrisentan is a medication prescribed to treat pulmonary hypertension. The peptide endothelin constricts blood vessel muscles, raising blood pressure.



What is ambrisentan used for?

Ambrisentan is used to treat the symptoms of pulmonary arterial hypertension, or high blood pressure in the major artery that carries blood from the right side of the heart (the ventricle) to the lungs, in order to enhance your capacity to exercise and reduce the progression of your illness.

What is the mechanism of action of ambrisentan?

As an endothelin receptor antagonist, Ambrisentan prevents endogenous endothelin peptide from constricting the muscles in blood vessels, allowing them to relax and permitting a reduction in blood pressure.

Does ambrisentan lower BP?

Ambrisentan decreases pulmonary blood pressure, allowing your heart to pump blood more effectively. Adults are treated with ambrisentan for pulmonary arterial hypertension (PAH). It enhances your capacity to exercise and keeps your condition from worsening.

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1007358-76-0: Ambrisentan (R)-Isomer

1007358-76-0: Ambrisentan (R)-Isomer
Catalogue No.




Molecular Formula


Molecular Weight

378.42 g/mol

Parent drug



(-)-(2R)-2-[(4, 6-Dimethylpyrimidin-2-yl)oxy]-3-methoxy-3, 3-diphenyl propanoic acid ; (R)-2-((4, 6-Dimethylpyrimidin-2-yl)oxy)-3-methoxy-3, 3-diphenylpropanoic Acid




Pasquini, Benedetta, et al. “Combined Approach Using Capillary Electrophoresis, NMR and Molecular Modeling for Ambrisentan Related Substances Analysis: Investigation of Intermolecular Affinities, Complexation and Separation Mechanism.” Journal of Pharmaceutical and Biomedical Analysis, vol. 144, Sept. 2017, pp. 220–29,




Ambrisentan (R)-Isomer

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