| Parent Drug Name | Name of Impurity | Catalogue No. | |
|---|---|---|---|
| Amifostine | Amifostine Disulfide Tetrahydrochloride | VE009627 | View CAS 10027-65-3 |
| Amifostine | Amifostine Impurity 1 | VL6220002 | View |
| Amifostine | Amifostine Impurity 10 TriHCl | VE0012146 | View CAS |
| Amifostine | Amifostine Impurity 2 | VL6220003 | View |
| Amifostine | Amifostine Impurity 3 | VL6220004 | View |
| Amifostine | Amifostine Impurity 4 | VL6220006 | View |
| Amifostine | Amifostine Impurity 5 (HCl) | VL6220007 | View |
| Amifostine | Amifostine Impurity 6 | VL6220008 | View |
| Amifostine | Amifostine Impurity 7 | VL6220009 | View |
| Amifostine | Amifostine Impurity 8 | VL6220010 | View |
| Amifostine | Amifostine Impurity 9 DiHBr | VL6220011 | View |
| Amifostine | Amifostine Thiol | VL6220012 | View CAS 31098-42-7 |
| Amifostine | Amifostine Thiol Dihydrochloride | VE009626 | View CAS 14653-77-1 |
| Amifostine | Amifostine Thiol-D6 Ditrifluoroacetate | DVE00144 | View |
| Amifostine | Amiloride EP Impurity B (Sodium Salt) | VL4630003 | View |
Amifostine Related Compound
Amifostine is also used to treat dry mouth induced by radiation therapy following head and neck cancer surgery.
References
- Amifostine.” National Cancer Institute, Cancer.gov, 9 Mar. 2017, www.cancer.gov/about-cancer/treatment/drugs/amifostine#:~:text=Amifostine%20is%20approved%20to%20prevent,cisplatin%20for%20advanced%20ovarian%20cancer. Accessed 21 Feb. 2023.
- Grdina, D. J., et al. “Amifostine: Mechanisms of Action Underlying Cytoprotection and Chemoprevention.” Drug Metabolism and Drug Interactions, vol. 16, no. 4, Jan. 2000, https://doi.org/10.1515/dmdi.2000.16.4.237. Accessed 21 Feb. 2023.
- Pereira, A. F., et al. “Amifostine Protects from the Peripheral Sensory Neuropathy Induced by Oxaliplatin in Mice.” Brazilian Journal of Medical and Biological Research, vol. 53, no. 11, 2020, https://doi.org/10.1590/1414-431×202010263. Accessed 21 Feb. 2023.
FAQ
What medical conditions does amifostine treat?
Amifostine is approved to protect against renal (kidney) toxicity. It is used to minimize the nephrotoxic effects of cisplatin therapy for advanced ovarian cancer.
What is the amifostine mechanism of action?
Amifostine protects the DNA from the harmful effects of ionizing radiation and chemotherapeutic drug-associated reactive species. It has anti-mutagenic and anti-cancer effects.
Does amifostine treat peripheral neuropathy?
Amifostine decreased the nociception generated by oxaliplatin in mice, indicating that it might be used to treat oxaliplatin-induced peripheral sensory neuropathy.
