Amiloride Impurities

Amiloride is also used to treat edema in congestive heart failure patients. Amiloride is a sort of diuretic (water pill) that aids in preventing excessive potassium loss from the body.

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Impurity structure Parent Drug Name Name of Impurity Catalogue No. CAS No.
Amiloride 5-Desamino Impurity Amiloride

Amiloride 5-Desamino Impurity

VL4630011 1203-87-8
Amiloride EP Impurity A Amiloride

Amiloride EP Impurity A

VL4630001 1458-01-1
Amiloride EP Impurity B Amiloride

Amiloride EP Impurity B

VL4630002 4878-36-8
Amiloride EP Impurity B (HCl Salt) Amiloride

Amiloride EP Impurity B (HCl Salt)

VL4630004 N/A
Amiloride EP Impurity C (HCl salt) Amiloride

Amiloride EP Impurity C (HCl salt)

VL4630006 1207-29-0

Amiloride Related Compound

By boosting urine flow, it decreases the body’s water retention, which lowers blood pressure.


  • “Amiloride: Uses, Interactions, Mechanism of Action | DrugBank Online.”, DrugBank, 2017, Accessed 24 Feb. 2023.
  • Haddy, F. J., et al. “Sodium Channel Blockers Are Vasodilator as Well as Natriuretic and Diuretic Agents.” Hypertension, vol. 7, no. 3_pt_2, May 1985, Accessed 24 Feb. 2023. ‌ ‌


What class of diuretic is amiloride?

Amiloride is classified as a diuretic that conserves potassium. When combined with another diuretic, such as a thiazide or loop diuretic, amiloride is frequently prescribed.

What is the mechanism of action of amiloride?

Amiloride works by interacting with amiloride-sensitive sodium channels to prevent sodium from being reabsorbed in the kidney’s collecting ducts and distal convoluted tubules. This encourages the body to lose water and salt while leaving potassium untouched.

Is amiloride a vasodilator?

In dogs and rats, 6-iodo-amiloride acts as a vasodilator, vasodepressor, natriuretic, and diuretic. It also causes a prolonged, significant drop in blood pressure in spontaneously hypertensive rats that is unrelated to urinary effects.