Amiloride Impurities

Amiloride is also used to treat edema in congestive heart failure patients. Amiloride is a sort of diuretic (water pill) that aids in preventing excessive potassium loss from the body.

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Parent Drug Name Name of Impurity Catalogue No.
Amiloride Amiloride 5-Desamino Impurity VL4630011View CAS 1203-87-8
Amiloride Amiloride EP Impurity A VL4630001View CAS 1458-01-1
Amiloride Amiloride EP Impurity B VL4630002View CAS 4878-36-8
Amiloride Amiloride EP Impurity B (HCl Salt) VL4630004View
Amiloride Amiloride EP Impurity C (HCl salt) VL4630006View CAS 1207-29-0

Amiloride Related Compound

By boosting urine flow, it decreases the body’s water retention, which lowers blood pressure.

References

  • “Amiloride: Uses, Interactions, Mechanism of Action | DrugBank Online.” Drugbank.com, DrugBank, 2017, go.drugbank.com/drugs/DB00594. Accessed 24 Feb. 2023.
  • Haddy, F. J., et al. “Sodium Channel Blockers Are Vasodilator as Well as Natriuretic and Diuretic Agents.” Hypertension, vol. 7, no. 3_pt_2, May 1985, https://doi.org/10.1161/01.hyp.7.3_pt_2.i121. Accessed 24 Feb. 2023. ‌ ‌

FAQ

What class of diuretic is amiloride?

Amiloride is classified as a diuretic that conserves potassium. When combined with another diuretic, such as a thiazide or loop diuretic, amiloride is frequently prescribed.

What is the mechanism of action of amiloride?

Amiloride works by interacting with amiloride-sensitive sodium channels to prevent sodium from being reabsorbed in the kidney’s collecting ducts and distal convoluted tubules. This encourages the body to lose water and salt while leaving potassium untouched.

Is amiloride a vasodilator?

In dogs and rats, 6-iodo-amiloride acts as a vasodilator, vasodepressor, natriuretic, and diuretic. It also causes a prolonged, significant drop in blood pressure in spontaneously hypertensive rats that is unrelated to urinary effects.

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1203-87-8: Amiloride 5-Desamino Impurity

1203-87-8: Amiloride 5-Desamino Impurity
Catalogue No.

VL4630011

CAS No.

1203-87-8

Molecular Formula

C6H7ClN6O

Molecular Weight

214.61

Parent drug

Amiloride

IUPAC Name

N-Amidino-3-amino-6-chloropyrazinecarboxamide

Synonyms

N/A

References

“N-Ethoxycarbonyl-2-Ethoxy-1, 2-Dihydroquinoline, Amiloride Analogues, and Renal Na+/H+ Antiporter, American Journal of Physiology-Renal Physiology.” American Journal of Physiology-Renal Physiology, 2020, journals.physiology.org/doi/abs/10.1152/ajprenal.1987.252.3.f517.

Status

In-stock

ListName

Amiloride 5-Desamino Impurity

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