| Parent Drug Name | Name of Impurity | Catalogue No. | |
|---|---|---|---|
| Amodiaquine | Amodiaquine Diethylamino Acetamide Impurity | VL6380008 | View CAS 121-78-8 |
| Amodiaquine | Amodiaquine Dihydrochloride Dihydrate | VL6380010 | View CAS 6398-98-7 |
| Amodiaquine | Amodiaquine Impurity 3 | VE007968 | View CAS 3011-34-5 |
| Amodiaquine | Amodiaquine Impurity 4 | VE007969 | View CAS 399-96-2 |
| Amodiaquine | Amodiaquine Impurity 5 | VE007970 | View CAS 71130-60-4 |
| Amodiaquine | Amodiaquine Impurity 6 | VE007971 | View CAS 79352-72-0 |
| Amodiaquine | Amodiaquine Impurity 7 | VE007973 | View CAS 37672-04-1 |
| Amodiaquine | Amodiaquine Impurity B | VL6380005 | View CAS 103-90-2 |
| Amodiaquine | Amodiaquine Inhouse Impurity A | VE007966 | View CAS 81080-09-3 |
| Amodiaquine | Amodiaquine Inhouse Impurity B | VE007967 | View CAS 81099-86-7 |
| Amodiaquine | Amodiaquine N-Desethyl HCl | VL6380011 | View CAS 1246819-11-3 |
| Amodiaquine | Amodiaquine N-Oxide | VE0012217 | View CAS 102391-07-1 |
| Amodiaquine | Amodiaquine-D10 | DVE0035 | View CAS 1189449-70-4 |
| Amodiaquine | N-Desethyl Amodiaquine Dihydrochloride | Vl6380001 | View CAS 79049-30-2 |
| Amodiaquine | N-Desethyl Amodiaquine-D5 Di(HCl) | DVE0034 | View CAS 1216894-33-5 |
Amodiaquine Related Compound
Amodiaquine has been related to severe episodes of acute hepatitis, which can be deadly, hence it is only suggested for use as a therapy and not for malaria prevention.
References
- “Amodiaquine.” Nih.gov, National Institute of Diabetes and Digestive and Kidney Diseases, 2 Feb. 2017, www.ncbi.nlm.nih.gov/books/NBK548404/#:~:text=Amodiaquine%20is%20an%20aminoquinoline%20used,not%20for%20prophylaxis%20against%20malaria. Accessed 10 July 2023.
- PubChem. “Amodiaquine.” @Pubchem, PubChem, 2023, pubchem.ncbi.nlm.nih.gov/compound/Amodiaquine. Accessed 10 July 2023.
FAQ
What is the mechanism of action of amodiaquine?
It is hypothesized to limit heme polymerase activity, like other quinoline derivatives. As a result, free heme accumulates, which is poisonous to the parasites. The medicine attaches to the free heme and prevents the parasite from converting to a less harmful form. This hazardous drug-heme combination affects membrane function.
Is amodiaquine a schizonticide for the blood?
Amodiaquine is quinoline-based blood schizonticidal medicine that kills malaria parasites, primarily P. falciparum.
What are the uses of amodiaquine?
Amodiaquine (ADQ) is a drug used to treat uncomplicated malaria, especially Plasmodium falciparum malaria. It is advised that it be taken in conjunction with artesunate to lessen the chance of resistance. Malaria prevention is not commonly suggested because of the possibility of uncommon but significant adverse effects.
