Amorolfine Impurities

Amorolfine is used to treat fungal infections in the nails.

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Impurity structure Parent Drug Name Name of Impurity Catalogue No. CAS No.
Amorolfine (2S,6R)-2,6-dimethylmorpholine hydrochloride Amorolfine

Amorolfine (2S,6R)-2,6-dimethylmorpholine hydrochloride

VL6390011 59229-60-6
Amorolfine 2-Hydroxy Impurity Amorolfine

Amorolfine 2-Hydroxy Impurity

VL6390002 N/A
Amorolfine Aldehyde Impurity Amorolfine

Amorolfine Aldehyde Impurity

VL6390018 67467-96-3
Amorolfine Chloro Racemate Amorolfine

Amorolfine Chloro Racemate

VL6390010 N/A
Amorolfine EP Impurity A Amorolfine

Amorolfine EP Impurity A

VL6390013 N/A
Amorolfine EP Impurity B Amorolfine

Amorolfine EP Impurity B

VL6390012 142347-84-0
Amorolfine EP Impurity C Amorolfine

Amorolfine EP Impurity C

VL6390004 78613-37-3
Amorolfine EP Impurity D Amorolfine

Amorolfine EP Impurity D

VL6390005 N/A
Amorolfine EP Impurity E Amorolfine

Amorolfine EP Impurity E

VL6390003 N/A
Amorolfine EP Impurity E (Mixture of Diastereomers) (HCl Salt) Amorolfine

Amorolfine EP Impurity E (Mixture of Diastereomers) (HCl Salt)

VE0012183 N/A
Amorolfine EP Impurity F Amorolfine

Amorolfine EP Impurity F

VL6390020 106614-66-8
Amorolfine EP Impurity G Amorolfine

Amorolfine EP Impurity G

VL6390021 N/A
Amorolfine EP Impurity H Amorolfine

Amorolfine EP Impurity H

VL6390022 N/A
Amorolfine EP Impurity I Amorolfine

Amorolfine EP Impurity I

VL6390023 67468-13-7
Amorolfine EP Impurity I (HCl Salt) Amorolfine

Amorolfine EP Impurity I (HCl Salt)

VE0012186 N/A
Amorolfine EP Impurity J Amorolfine

Amorolfine EP Impurity J

VL6390014 N/A
Amorolfine EP Impurity K Amorolfine

Amorolfine EP Impurity K

VL6390007 N/A
Amorolfine EP Impurity L Amorolfine

Amorolfine EP Impurity L

VL6390008 N/A
Amorolfine EP Impurity M Amorolfine

Amorolfine EP Impurity M

VE007981 N/A
Amorolfine EP Impurity O Amorolfine

Amorolfine EP Impurity O

VE007982 73414-18-3
Amorolfine HCl Amorolfine

Amorolfine HCl

VL6390001 78613-38-4
Amorolfine Hydroxy S-Isomer Amorolfine

Amorolfine Hydroxy S-Isomer

VL6390024 1456707-65-5
Amorolfine Impurity 10 Amorolfine

Amorolfine Impurity 10

VL6390006 N/A
Amorolfine Impurity 14 Amorolfine

Amorolfine Impurity 14

VE0012184 N/A
rac-Amorolfine Impurity 4 Amorolfine

rac-Amorolfine Impurity 4

VL6390015 N/A
(2S,6R)-4-(3-(4-isopropylphenyl)-2-methylpropyl)-2,6-dimethylmorpholine Amorolfine

(2S,6R)-4-(3-(4-isopropylphenyl)-2-methylpropyl)-2,6-dimethylmorpholine

VL63900016 N/A
1-iodo-3-(tert-pentyl)benzene Amorolfine

1-iodo-3-(tert-pentyl)benzene

VL6390009 N/A

Abacavir Related Compound

Fungal nail infection is frequently caused by a fungal skin infection. The infection causes your nail(s) to thicken and discolor, and it can be uncomfortable.

References

FAQ

What class does Amorolfine belong to?

Amorolfine, a morpholine derivative, is the first antifungal medication of a new class. The mechanism of action is ergosterol production suppression in the fungal cell membrane.

What is amorolfine used for?

AMOROLFINE is a topical antifungal that is primarily used to treat fungal infections of the nails and skin such as ringworm, jock itch, and athlete’s foot, as well as seborrhea dermatitis (dry, flaky skin on the face, scalp, and chest, upper back, or ears) and pityriasis (a type of skin rash that causes scaly, discolored patches on the chest, back, and face).

Is amorolfine fungicidal or fungistatic?

Amorolfine is a structurally distinct, topically active antifungal drug with in vitro fungistatic and fungicidal action. Its in vitro activity range includes dermatophytes, dimorphic, certain dematiaceous and filamentous fungi, and yeasts.