Anthraquinone Impurities

Anthraquinones are bioactive natural compounds, some of which are active ingredients in pharmaceuticals, particularly Chinese remedies.

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Impurity structure Parent Drug Name Name of Impurity Catalogue No. CAS No.
Anthraquinone 1,4,5-Trihydroxyanthraquinone Anthraquinone

Anthraquinone 1,4,5-Trihydroxyanthraquinone

VL6700005 2961-04-8
Anthraquinone 1,5-Dihydroxyanthraquinone Anthraquinone

Anthraquinone 1,5-Dihydroxyanthraquinone

VL6700004 117-12-4

Anthraquinone Related Compound

These compounds have purgative, anti-inflammation, immunoregulation, antihyperlipidemia, and anticancer properties.



What is the mechanism of action of Anthraquinone in laxatives?

Two distinct mechanisms of action have been proposed: (1) an effect on large intestine motility, resulting in accelerated colonic transit and decreased fluid absorption, and (2) an effect on secretory processes, resulting in increased fluid absorption. One major biological target is the blockage of Cl channels across colon cells, which contributes to the laxative effect [2]. Furthermore, those 1,8-dihydroxyanthrones/anthraquinones with an extra phenolic hydroxyl group block the Na+/K+-ATPase pump.

What is the function of anthraquinone?

Apart from its usage as colorants, anthraquinone derivatives have been utilized in medicine for centuries, for example, as laxatives, antibacterial and anti-inflammatory medicines. Current therapeutic indications include constipation, arthritis, multiple sclerosis, and malignancy.

Is anthraquinone an antioxidant?

The anthraquinones, which also have antioxidant activity, had essentially no reducing power, implying that, with the exception of anthrone and alizarin, the reducing power of other anthraquinonoids cannot be considered as contributing to their antioxidative action.