Arbutin Impurities

Arbutin is a skin-brightening agent that is effective against dark spots, hyperpigmentation, and scarring. also, it’s used for is a skin-lightening agent that enhances skin tone and brightness.

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Impurity structure Parent Drug Name Name of Impurity Catalogue No. CAS No.
Alpha Arbutin Arbutin

Alpha Arbutin

VE0012274 84380-01-8
Arbutin-D4 Arbutin

Arbutin-D4

DVE0062 N/A

Arbutin Related Compound

Because it suppresses melanin formation, it is beneficial in spot fading.

References

  • García-Jiménez, Antonio, et al. Action of Tyrosinase on Alpha and Beta-Arbutin: A Kinetic Study. no. 5, May 2017, pp. e0177330–30, https://doi.org/10.1371/journal.pone.0177330. Accessed 24 July 2023.
  • “Arbutin: Uses, Interactions, Mechanism of Action | DrugBank Online.” Drugbank.com, DrugBank, 2013, go.drugbank.com/drugs/DB11217. Accessed 24 July 2023.

FAQ

What is the pharmacological action of arbutin?

Arbutin is a hydroquinone glycoside, although the hydroquinone molecule is not primarily responsible for arbutin’s depigmenting properties. It suppresses melanogenesis and mediates its de-pigmenting effects on human skin by acting as a competitive inhibitor of the tyrosinase enzyme at the L-tyrosine binding site.

Is arbutin a tyrosinase inhibitor?

It has been reported that -arbutin inhibits tyrosinase activity but not its biosynthesis in human melanocyte cultures. tyrosinase is an enzyme that regulates rate-limiting processes in the synthesis of melanin.

What is the use of arbutin?

Arbutin is a skin-brightening agent that is effective against dark spots, hyperpigmentation, and scarring. Arbutin is a skin-lightening agent that enhances skin tone and brightness. Because it suppresses melanin formation, it is beneficial in spot fading.