Atovaquone Impurities

Pneumocystis jiroveci [Pneumocystis carinii] pneumonia (PCP; a form of pneumonia most likely to infect persons with human immunodeficiency virus [HIV]) in teens and adults is treated with atovaquone.

veeprho banner
Parent Drug Name Name of Impurity Catalogue No.
Atovaquone Atovaquone EP Impurity A VL1370001View
Atovaquone Atovaquone EP Impurity C VL1370004View CAS 1809464-27-4
Atovaquone Atovaquone EP Impurity D VL1370003View CAS 129700-41-0
Atovaquone Atovaquone Impurity 1 VE0012408View CAS 91161-85-2
Atovaquone Atovaquone Impurity 2 VE0012409View CAS 49708-81-8
Atovaquone Atovaquone Impurity 3 (Mixture of cis and trans Isomers) VE0012421View CAS 95233-36-6
Atovaquone Atovaquone Impurity 4 VE0012411View CAS 2171347-18-3
Atovaquone Atovaquone Related Compound 1 VE0012422View CAS 1346600-43-8
Atovaquone Atovaquone Related Compound A VL1370002View CAS 137732-39-9
Atovaquone Atovaquone-d4 DVE00168View
Atovaquone Cis-Atovaquone-d4 DVE00169View

Atovaquone Related Compound

Atovaquone displays antifungal efficacy against clinical isolates of Aspergillus and Fusarium, with Fusarium species being more susceptible to atovaquone than Aspergillus species.

References

  • Clark, Heather, et al. Atovaquone Impairs Growth of Aspergillus and Fusarium Keratitis Isolates by Modulating Mitochondrial Function and Zinc Homeostasis. no. 3, Mar. 2018, pp. 1589–89, https://doi.org/10.1167/iovs.17-22585. Accessed 30 July 2023.
  • ‌Srivastava, Indresh K., et al. Atovaquone, a Broad Spectrum Antiparasitic Drug, Collapses Mitochondrial Membrane Potential in a Malarial Parasite. no. 7, Feb. 1997, pp. 3961–66, https://doi.org/10.1074/jbc.272.7.3961. Accessed 30 July 2023.

FAQ

What is the mode of action of atovaquone?

Atovaquone inhibits parasite mitochondrial electron transport selectively. Proguanil hydrochloride works largely through its metabolite cycloguanil, which is a dihydrofolate reductase inhibitor. The malaria parasite’s dihydrofolate reductase inhibition affects deoxy thymidylate production.

Is atovaquone an antifungal?

Atovaquone displays antifungal efficacy against clinical isolates of Aspergillus and Fusarium, with Fusarium species being more susceptible to atovaquone than Aspergillus species. Atovaquone also decreased labile intracellular zinc levels and boosted Aspergillus’s sensitivity to metal shock.

Is atovaquone antiparasitic?

Atovaquone, a hydroxynaphthoquinone, was originally created as an antimalarial but is now proven to be effective against a variety of other eukaryotic microbial parasites including toxoplasma and pneumocystis. Plasmodium falciparum and P. falciparum mitochondria were cholate-lyzed.

[rfq_list]

Request a quote

129700-41-0: Atovaquone EP Impurity D

129700-41-0: Atovaquone EP Impurity D
Catalogue No.

VL1370003

CAS No.

129700-41-0

Molecular Formula

C23H21ClO3

Molecular Weight

380.86

Parent drug

Atovaquone

IUPAC Name

Trans-2-[4-(4-Chlorophenyl)cyclohexyl]-3-methoxy-1, 4-naphthalenedione; 2

Synonyms

O-Methyl Atovaquone

References

Status

In-stock

ListName

Atovaquone EP Impurity D

Exclusively Supplied by Veeprho

Exclusively Supplied by Veeprho

"*" indicates required fields

Hidden
Products quotation
Name
Url
 
Hidden