| Parent Drug Name | Name of Impurity | Catalogue No. | |
|---|---|---|---|
| Atovaquone | Atovaquone EP Impurity A | VL1370001 | View |
| Atovaquone | Atovaquone EP Impurity C | VL1370004 | View CAS 1809464-27-4 |
| Atovaquone | Atovaquone EP Impurity D | VL1370003 | View CAS 129700-41-0 |
| Atovaquone | Atovaquone Impurity 1 | VE0012408 | View CAS 91161-85-2 |
| Atovaquone | Atovaquone Impurity 2 | VE0012409 | View CAS 49708-81-8 |
| Atovaquone | Atovaquone Impurity 3 (Mixture of cis and trans Isomers) | VE0012421 | View CAS 95233-36-6 |
| Atovaquone | Atovaquone Impurity 4 | VE0012411 | View CAS 2171347-18-3 |
| Atovaquone | Atovaquone Related Compound 1 | VE0012422 | View CAS 1346600-43-8 |
| Atovaquone | Atovaquone Related Compound A | VL1370002 | View CAS 137732-39-9 |
| Atovaquone | Atovaquone-d4 | DVE00168 | View |
| Atovaquone | Cis-Atovaquone-d4 | DVE00169 | View |
Atovaquone Related Compound
Atovaquone displays antifungal efficacy against clinical isolates of Aspergillus and Fusarium, with Fusarium species being more susceptible to atovaquone than Aspergillus species.
References
- Clark, Heather, et al. Atovaquone Impairs Growth of Aspergillus and Fusarium Keratitis Isolates by Modulating Mitochondrial Function and Zinc Homeostasis. no. 3, Mar. 2018, pp. 1589–89, https://doi.org/10.1167/iovs.17-22585. Accessed 30 July 2023.
- Srivastava, Indresh K., et al. Atovaquone, a Broad Spectrum Antiparasitic Drug, Collapses Mitochondrial Membrane Potential in a Malarial Parasite. no. 7, Feb. 1997, pp. 3961–66, https://doi.org/10.1074/jbc.272.7.3961. Accessed 30 July 2023.
FAQ
What is the mode of action of atovaquone?
Atovaquone inhibits parasite mitochondrial electron transport selectively. Proguanil hydrochloride works largely through its metabolite cycloguanil, which is a dihydrofolate reductase inhibitor. The malaria parasite’s dihydrofolate reductase inhibition affects deoxy thymidylate production.
Is atovaquone an antifungal?
Atovaquone displays antifungal efficacy against clinical isolates of Aspergillus and Fusarium, with Fusarium species being more susceptible to atovaquone than Aspergillus species. Atovaquone also decreased labile intracellular zinc levels and boosted Aspergillus’s sensitivity to metal shock.
Is atovaquone antiparasitic?
Atovaquone, a hydroxynaphthoquinone, was originally created as an antimalarial but is now proven to be effective against a variety of other eukaryotic microbial parasites including toxoplasma and pneumocystis. Plasmodium falciparum and P. falciparum mitochondria were cholate-lyzed.
