Azithromycin Impurities

Azithromycin is a broad-spectrum macrolide antibiotic with a longer half-life and high tissue penetration. It is mostly used to treat respiratory, enteric, and genitourinary infections, although it can also be used to treat certain sexually transmitted and enteric diseases in place of other macrolides.

Azithromycin has additional immunomodulatory properties and has been utilised in chronic respiratory inflammatory disorders for this purpose.

Cardiovascular arrhythmias and hearing loss are two serious side effects that might occur.

Azithromycin inhibits bacterial protein production by targeting the sensitive bacterial ribosome’s 50S subunit Protein synthesis decreases in response to an increase in macrolide concentration.

The unionized form of Azithromycin membrane penetration rate is greater, which might explain why Azithromycin has enhanced antibacterial action at alkaline pH. Azithromycin binds to a location on 23S rRNA near the peptidyl transferase center called the nascent peptide exit tunnel (which is roughly 100 long and 10-20 broad) and partially occludes it.

Azithromycin is associated with QTc prolongation. Particularly in patients with a known history of QTc interval perturbation, and cardiac arrhythmia, while azithromycin causes substantial hepatotoxicity.

Anaphylaxis, SJS, and drug reaction with eosinophilia and systemic symptoms (DRESS) are uncommon kinds of immune allergic responses.