Bexarotene Impurities

Bexarotene is employed to manage cutaneous T-cell lymphoma (CTCL, a kind of lymphoma [cancer] that targets the skin) in patients who have failed to respond to at least one prior drug.

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Parent Drug Name Name of Impurity Catalogue No.
Bexarotene Bexarotene Acyl Glucuronide VE0012742View CAS 198700-33-3
Bexarotene Bexarotene Amide Impurity VE006531View
Bexarotene Bexarotene Impurity 11 VE0012739View
Bexarotene Bexarotene Impurity 12 VE0012740View
Bexarotene Bexarotene Impurity 8 VE0012731View CAS 29641-87-0
Bexarotene Bexarotene Keto Acid Impurity VE006530View CAS 153559-46-7
Bexarotene Bexarotene Ketone Methyl Ester Impurity VE006533View CAS 153559-45-6
Bexarotene Bexarotene Methyl Ester Impurity VE006534View CAS 153559-48-9
Bexarotene Bexarotene Tetrahydro Naphthalene Impurity VE006532View CAS 6683-48-3
Bexarotene Bexarotene-D4 DVE00227View
Bexarotene 6-Hydroxy Bexarotene VE0012741View
Bexarotene 7-Oxo Bexarotene VE0012743View CAS 368451-15-4

Bexarotene Related Compound

Bexarotene belongs to the retinoids class of medicines. It works by preventing cancer cell development.

References

  • “Targretin (Bexarotene) Dosing, Indications, Interactions, Adverse Effects, and More.” Medscape.com, 13 Apr. 2023, reference.medscape.com/drug/targretin-bexarotene-342234#:~:text=Hypoglycemia%20has%20not%20been%20associated%20with%20bexarotene%20monotherapy.&text=siponimod%20and%20bexarotene%20both%20increase%20immunosuppressive%20effects%3B%20risk%20of%20infection. Accessed 25 Aug. 2023.
  • “Bexarotene: MedlinePlus Drug Information.” Medlineplus.gov, 2023, medlineplus.gov/druginfo/meds/a608006.html#:~:text=Bexarotene%20is%20used%20to%20treat,the%20growth%20of%20cancer%20cells. Accessed 25 Aug. 2023.
  • “Bexarotene | DermNet.” Dermnetnz.org, 2022, dermnetnz.org/topics/bexarotene#:~:text=Kaposi%20sarcoma-,Mechanism%20of%20action%20of%20bexarotene,growth%2C%20apoptosis%2C%20and%20differentiation. Accessed 25 Aug. 2023.

FAQ

What is the mechanism of action of bexarotene?

Bexarotene binds and activates RXRs, which are ligand-activated transcription factors that regulate gene expression. This affects cell proliferation, apoptosis, and differentiation.

What are the indications for bexarotene?

Bexarotene capsules are approved for the treatment of cutaneous symptoms of cutaneous T-cell lymphoma.

What class of drug is bexarotene?

Bexarotene belongs to the retinoids class of medicines. It works by preventing cancer cell development.

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153559-45-6: Bexarotene Ketone Methyl Ester Impurity

153559-45-6: Bexarotene Ketone Methyl Ester Impurity
Catalogue No.

VE006533

CAS No.

153559-45-6

Molecular Formula

C24H28O3

Molecular Weight

364.48

Parent drug

Bexarotene

IUPAC Name

Methyl 4-[(3, 5, 5, 8, 8-pentamethyl-5, 6, 7, 8-tetrahydro-2-naphthyl)carbonyl]benzoate

Synonyms

N/A

References

Bexarotene Ketone Methyl Ester Impurity ( CAS No: 153559-45-6 ) or Methyl 4-[(3, 5, 5, 8, 8-pentamethyl-5, 6, 7, 8-tetrahydro-2-naphthyl)carbonyl]benzoate is associate impurity of Bexarotene.Bexarotene is a selective retinoid X receptor (RXR) agonist and an antineoplastic agent

Status

In-stock

ListName

Bexarotene Ketone Methyl Ester Impurity

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