Brimonidine Impurities

Abacavir is used in the treatment of human immunodeficiency virus (HIV) infection in conjunction with other medications.

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Impurity structure Parent Drug Name Name of Impurity Catalogue No. CAS No.
Brimonidine 2,3-Dione Impurity Brimonidine

Brimonidine 2,3-Dione Impurity

VE007423 182627-95-8
Brimonidine Acrylate Brimonidine

Brimonidine Acrylate

VE007429 N/A
Brimonidine Carbamothioate Impurity Brimonidine

Brimonidine Carbamothioate Impurity

VE007424 842138-75-4
Brimonidine Dimer Impurity Brimonidine

Brimonidine Dimer Impurity

VE007428 N/A
Brimonidine EP Impurity A Brimonidine

Brimonidine EP Impurity A

VL1910004 91147-43-2
Brimonidine EP Impurity B Brimonidine

Brimonidine EP Impurity B

VL1910003 50358-63-9
Brimonidine EP Impurity C Brimonidine

Brimonidine EP Impurity C

VL1910002 6298-37-9
Brimonidine EP Impurity D Brimonidine

Brimonidine EP Impurity D

VL1910005 842138-74-3
Brimonidine EP Impurity E Brimonidine

Brimonidine EP Impurity E

VL1910001 168329-48-4
Brimonidine EP Impurity F Brimonidine

Brimonidine EP Impurity F

VE007425 151110-15-5
Brimonidine EP Impurity G Brimonidine

Brimonidine EP Impurity G

VE006448 1216379-05-3
Brimonidine EP Impurity G (HCl Salt) Brimonidine

Brimonidine EP Impurity G (HCl Salt)

VE0012890 N/A
Brimonidine EP Impurity H Brimonidine

Brimonidine EP Impurity H

VE006452 91147-46-5
Brimonidine Impurity 12 Brimonidine

Brimonidine Impurity 12

VE0012899 N/A
Brimonidine Impurity 2 Brimonidine

Brimonidine Impurity 2

VE0011156 N/A
Brimonidine Impurity 6 (Na Salt) Brimonidine

Brimonidine Impurity 6 (Na Salt)

VE0012891 N/A
Brimonidine Impurity 8 Brimonidine

Brimonidine Impurity 8

VE0012892 40254-90-8
Brimonidine Impurity 9 Brimonidine

Brimonidine Impurity 9

VE0012894 N/A
Brimonidine Inhouse Impurity I Brimonidine

Brimonidine Inhouse Impurity I

VE007431 134892-46-9
Brimonidine Nitroso Impurity Brimonidine

Brimonidine Nitroso Impurity

VE0010619 N/A
Brimonidine Related Impurity 4 Brimonidine

Brimonidine Related Impurity 4

VE007430 182628-02-0
Brimonidine Tartrate Impurity 3 Brimonidine

Brimonidine Tartrate Impurity 3

VE007426 1217439-06-9
Brimonidine Tartrate Impurity 8 Brimonidine

Brimonidine Tartrate Impurity 8

VE0012898 934548-66-0
Brimonidine-D4 Brimonidine

Brimonidine-D4

DVE00246 1184971-51-4
N-​(2-​Aminoethyl)​-​N'-​(5-​bromo-​6-​quinoxalinyl)​thiourea Brimonidine

N-​(2-​Aminoethyl)​-​N'-​(5-​bromo-​6-​quinoxalinyl)​thiourea

VE008657 134892-47-0
6-Isothiocyanatoquinoxaline Brimonidine

6-Isothiocyanatoquinoxaline

VE007427 135306-56-8

Brimonidine Related Compound

It is an alpha-2 adrenergic agonist used to treat face erythema in rosacea, glaucoma, and ocular hypertension.

References

  • Cantor, Louis B. “Brimonidine in the Treatment of Glaucoma and Ocular Hypertension.” Therapeutics and Clinical Risk Management, vol. 2, no. 4, Dove Medical Press, Dec. 2006, pp. 337–46, https://doi.org/10.2147/tcrm.2006.2.4.337. Accessed 31 Aug. 2023.
  • “Brimonidine Ophthalmic: MedlinePlus Drug Information.” Medlineplus.gov, 2018, medlineplus.gov/druginfo/meds/a601232.html#:~:text=Ophthalmic%20brimonidine%20is%20used%20to,enough%20to%20cause%20vision%20loss). Accessed 31 Aug. 2023.

FAQ

What is the therapeutic action of brimonidine?

Brimonidine lowers intraocular pressure by reducing the formation of aqueous humor and, over time, also enhances uveoscleral outflow via acting on the iris-ciliary body 2-adrenergic receptors.

Is brimonidine a vasodilator?

Through the release of endothelium-derived relaxing factor via the 2-adrenergic receptors on endothelial cells, brimonidine tartrate may also cause vasodilation. The positive impact of 0.2% brimonidine tartrate on intraocular pressure was verified by our findings.

What class of drug is brimonidine?

Alpha-adrenergic agonists are a group of medications that includes brimonidine. Brimonidine reduces the quantity of fluid in the eyes in order to work.