Camptothecin Impurities

An alkaloid known as camptothecin, a quinolone, is used as a chemotherapy drug to treat leukemia.

Show
per page
Impurity structure Parent Drug Name Name of Impurity Catalogue No. CAS No.
Camptothecin Impurity 8 Camptothecin

Camptothecin Impurity 8

VE0013180 110351-93-4
Camptothecin Impurity 9 (HCl Salt) Camptothecin

Camptothecin Impurity 9 (HCl Salt)

VE0013178 N/A
7-Ethyl-10-Hydroxy Camptothecin Camptothecin

7-Ethyl-10-Hydroxy Camptothecin

VE009610 130144-34-2

Camptothecin Related Compound

Inhibiting both DNA replication’s cleavage and religation events, camptothecin interacts with type I DNA topoisomerase to stop L’s growth. A common anti-tumor medication called camptothecin particularly blocks DNA topoisomerase I. Topoisomerase I is thought to take part in transcription by reducing the torsional stress that the elongating RNA polymerase causes to the duplex DNA.

References

  • Mats Ljungman, and Philip C. Hanawalt. “The Anti-Cancer Drug Camptothecin Inhibits Elongation but Stimulates Initiation of RNA Polymerase II Transcription.” Carcinogenesis, vol. 17, no. 1, Oxford University Press, Jan. 1996, pp. 31–36, https://doi.org/10.1093/carcin/17.1.31. Accessed 9 Sept. 2023.
  • “Camptothecin: Uses, Interactions, Mechanism of Action | DrugBank Online.” Drugbank.com, DrugBank, 2013, go.drugbank.com/drugs/DB04690. Accessed 9 Sept. 2023.
  • Takimoto, Chris H., et al. “Clinical Applications of the Camptothecins.” Biochimica et Biophysica Acta (N), vol. 1400, no. 1-3, Elsevier BV, Oct. 1998, pp. 107–19, https://doi.org/10.1016/s0167-4781(98)00130-4. Accessed 9 Sept. 2023.

FAQ

What class does Camptothecin belong to?

M.E. Wall and M.C. Wani developed the topoisomerase I inhibitor camptothecin (CPT) in 1966. It is isolated from Camptotheca acuminita, a plant used in traditional Chinese medicine to cure cancer. Topoisomerase and DNA are both bound by CPT by hydrogen bonds, which stop DNA religation.

What is the mechanism of camptothecin?

S-phase-specific killing caused by potentially fatal collisions between advancing replication forks and topo-I cleavable complexes is the main mechanism by which CPT kills cells.

Which enzyme is the target of camptothecin?

The human enzyme nuclear DNA topoisomerase I (TOP1) is crucial. It is the only known target of the powerful anticancer drugs irinotecan and topotecan, which are made from the alkaloid camptothecin.