Capecitabine Impurities

Capecitabine is a chemotherapeutic drug.

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Impurity structure Parent Drug Name Name of Impurity Catalogue No. CAS No.
Capecitabine 3-O-BDR Impurity Capecitabine

Capecitabine 3-O-BDR Impurity

VE007562 1262133-64-1
Capecitabine alpha-Isomer Capecitabine

Capecitabine alpha-Isomer

VE007563 N/A
Capecitabine Descarbamate Diacetyl alpha-Isomer Capecitabine

Capecitabine Descarbamate Diacetyl alpha-Isomer

VE007564 N/A
Capecitabine EP Impurity A Capecitabine

Capecitabine EP Impurity A

VL243001 66335-38-4
Capecitabine EP Impurity B Capecitabine

Capecitabine EP Impurity B

VL243002 3094-09-5
Capecitabine EP Impurity C Capecitabine

Capecitabine EP Impurity C

VL243010 161599-46-8
Capecitabine EP Impurity D Capecitabine

Capecitabine EP Impurity D

VL243008 910129-15-6
Capecitabine EP Impurity E Capecitabine

Capecitabine EP Impurity E

VL243009 162204-30-0
Capecitabine EP Impurity F Capecitabine

Capecitabine EP Impurity F

VL243003 921769-65-5
Capecitabine EP Impurity G Capecitabine

Capecitabine EP Impurity G

VL243004 162204-20-8
Capecitabine Impurity 12 Capecitabine

Capecitabine Impurity 12

VE0013143 N/A
Capecitabine Impurity 13 Capecitabine

Capecitabine Impurity 13

VE0013144 62211-93-2
Capecitabine Impurity 14 (Mixture of Diastereomers) Capecitabine

Capecitabine Impurity 14 (Mixture of Diastereomers)

VE0013146 N/A
Capecitabine Impurity 15 (Mixture of Diastereomers) Capecitabine

Capecitabine Impurity 15 (Mixture of Diastereomers)

VE0013148 N/A
Capecitabine Impurity 16 Capecitabine

Capecitabine Impurity 16

VE0013151 N/A
Capecitabine Impurity 19 Capecitabine

Capecitabine Impurity 19

VE0013153 N/A
Capecitabine Impurity 3 Capecitabine

Capecitabine Impurity 3

VE007568 216450-02-1
Capecitabine Impurity 4 Capecitabine

Capecitabine Impurity 4

VE007569 1313238-38-8
Capecitabine Impurity 5 Capecitabine

Capecitabine Impurity 5

VE0013142 N/A
Capecitabine Impurity A CRS (Y0001643) Capecitabine

Capecitabine Impurity A CRS (Y0001643)

PVE00385 66335-38-4
Budesonide for System Suitability CRS (Y0001148) Capecitabine

Capecitabine Impurity B CRS (Y0001644)

PVE00386 154361-50-9
Capecitabine Methoxy Analog Capecitabine

Capecitabine Methoxy Analog

VE007565 N/A
Capecitabine Related Compound I Capecitabine

Capecitabine Related Compound I

VL243007 1262133-68-5
Capecitabine USP Impurity H Capecitabine

Capecitabine USP Impurity H

VL243006 1262133-66-3
Capecitabine α-Isomer Capecitabine

Capecitabine α-Isomer

VE007025 N/A
Capecitabine α-Isomer Diacetyl Impurity Capecitabine

Capecitabine α-Isomer Diacetyl Impurity

VE007566 N/A
Capecitabine-D11 Capecitabine

Capecitabine-D11

DVE00287 1132662-08-8
N-Carbamoyl-2-fluoro-β-alanine Capecitabine

N-Carbamoyl-2-fluoro-β-alanine

VE0010217 5006-64-4
Tetrahydrouridine Capecitabine

Tetrahydrouridine

VE007567 18771-50-1
5-Fluoro-2-methoxypyrimidin-4-amine Capecitabine

5-Fluoro-2-methoxypyrimidin-4-amine

VE0019532 1993-63-1

Capecitabine Related Compound

It is used to treat several forms of cancer, including colon cancer. Capecitabine may be used alone or in combination with other chemotherapy medicines.

References

  • “Capecitabine and Radiation Therapy in Treating Patients with Nonmetastatic Breast Cancer after Surgery – Full Text View – ClinicalTrials.gov.” Clinicaltrials.gov, 2019, classic.clinicaltrials.gov/ct2/show/NCT00562718. Accessed 11 Sept. 2023.
  • Walko, Christine M., and Celeste Lindley. “Capecitabine: A Review.” Clinical Therapeutics, vol. 27, no. 1, Elsevier BV, Jan. 2005, pp. 23–44, https://doi.org/10.1016/j.clinthera.2005.01.005. Accessed 11 Sept. 2023.

FAQ’s

What is the therapeutic action of capecitabine?

Capecitabine is a chemotherapeutic drug that is taken orally and is used to treat metastatic breast and colorectal cancers. Capecitabine is a prodrug that is metabolized to fluorouracil (antimetabolite) in the tumor, where it inhibits DNA synthesis and reduces tumor development.

What is capecitabine used for in cancer?

Capecitabine is an antimetabolite, which is a kind of chemotherapy medication. Capecitabine is broken down in the body into chemicals that interfere with the creation of DNA, RNA, and proteins. This prevents cancer cells from multiplying.

Why is capecitabine used with radiation?

To eliminate tumor cells, radiation treatment employs high-energy X-rays. Capecitabine may potentially increase the sensitivity of tumor cells to radiation treatment. Following surgery, using radiation together with capecitabine may eliminate any residual tumor cells.