Daclatasvir Impurities

• Daclatasvir can be taken with or without food.
• Taking it with food may help reduce stomach upset for some patients.
• Consistency is key – Take it at the same time every day to maintain steady blood levels.

• 12 to 24 weeks depending on:
  • HCV genotype (1–6).
  • Co-infection with HIV.
  • Presence of cirrhosis (compensated or decompensated).
  • Combination with sofosbuvir and/or ribavirin.
• Most common regimen: Daclatasvir + Sofosbuvir for 12 weeks (no cirrhosis) or 24 weeks (with cirrhosis).

Common side effects include:

• Headache – Most frequently reported.
• Fatigue and weakness – Often seen in combination therapy.
• Nausea and diarrhea – Mild and usually transient.
• Insomnia – Difficulty falling or staying asleep.
• Anemia – Particularly if taken with ribavirin.
• Serious side effects are rare but may include:
  • Bradycardia (slow heart rate) when combined with amiodarone and sofosbuvir.
  • Severe liver problems in patients with advanced cirrhosis.

• HCV and HIV co-infection – Effective in managing hepatitis C in patients also living with HIV.
• Off-label:
  • Hepatitis C recurrence post-liver transplant.
  • Hepatitis C-related cryoglobulinemia – A rare condition causing vasculitis and kidney damage.
• Investigational:
  • Potential antiviral effects against other flaviviruses like Dengue and Zika (limited studies).