Enzalutamide Impurities and Related Compound

Enzalutamide Impurities

Enzalutamide, sold under the brand name Xtandi, is a nonsteroidal antiandrogen medication used in the treatment of prostate cancer. It works by inhibiting androgen receptors, blocking the effects of testosterone and other androgens that stimulate the growth of prostate cancer cells. Enzalutamide is commonly prescribed for metastatic and non-metastatic castration-resistant prostate cancer (CRPC) and is often part of combination therapy.

Structure

Product Name

CAS No.

Cat No.

Action

Enzalutamide Carboxylic Acid

Parent: Enzalutamide

CAS No.: 1242137-15-0

Cat No.: VE006365

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Enzalutamide Desfluoro Impurity

Parent: Enzalutamide

CAS No.: 915087-16-0

Cat No.: VE0010715

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Enzalutamide Desfluoro N-Methyl Impurity

Parent: Enzalutamide

CAS No.: N/A

Cat No.: VE0028848

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Enzalutamide Impurity 10

Parent: Enzalutamide

CAS No.: N/A

Cat No.: VE0015003

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Enzalutamide Impurity 11

Parent: Enzalutamide

CAS No.: 112704-79-7

Cat No.: VE0027618

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Enzalutamide Impurity 12

Parent: Enzalutamide

CAS No.: 1802242-43-8

Cat No.: VE0015007

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Enzalutamide Impurity 14

Parent: Enzalutamide

CAS No.: 1289942-55-7

Cat No.: VE0010439

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Enzalutamide Impurity 2

Parent: Enzalutamide

CAS No.: 143782-23-4

Cat No.: VE006366

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Enzalutamide Impurity 20

Parent: Enzalutamide

CAS No.: 1242137-19-4

Cat No.: VE0015008

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Enzalutamide Impurity 21

Parent: Enzalutamide

CAS No.: 1332524-02-3

Cat No.: VE0015010

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Enzalutamide Impurity 5

Parent: Enzalutamide

CAS No.: 1242137-20-7

Cat No.: VE0015001

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Enzalutamide Impurity 66

Parent: Enzalutamide

CAS No.: 2029195-97-7

Cat No.: VE0023865

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Enzalutamide Impurity 7

Parent: Enzalutamide

CAS No.: 1839619-50-9

Cat No.: VE006573

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Enzalutamide Impurity F

Parent: Enzalutamide

CAS No.: 2810090-73-2

Cat No.: VE0011715

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Enzalutamide Inhouse Impurity L

Parent: Enzalutamide

CAS No.: 2030242-21-6

Cat No.: VE008226

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Enzalutamide Inhouse Impurity O

Parent: Enzalutamide

CAS No.: 3035510-40-5

Cat No.: VE008225

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Enzalutamide Mono Nitroso Methyl Ester

Parent: Enzalutamide

CAS No.: N/A

Cat No.: VE0025432

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Enzalutamide Oxo Impurity

Parent: Enzalutamide

CAS No.: 1242137-18-3

Cat No.: VE006364

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Enzalutamide Reference Standard

Parent: Enzalutamide

CAS No.: 915087-33-1

Cat No.: VE0027814

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Ethyl 2-((3-fluoro-4-(methylcarbamoyl)phenyl)(nitroso)amino)-2-methylpropanoate

Parent: Enzalutamide

CAS No.: N/A

Cat No.: VE0024026

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Ethyl 2-(4- (Methylcarbamoyl)-3-Fluoro Phenylamino)-2-Methyl propanoate

Parent: Enzalutamide

CAS No.: 1258638-92-4

Cat No.: VE006574

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Methyl (4-cyano-3-(trifluoromethyl)phenyl)carbamodithioate

Parent: Enzalutamide

CAS No.: N/A

Cat No.: VE009236

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Methyl 2-((3-fluoro-4-(methylcarbamoyl)phenyl)(nitroso)amino)-2-methylpropanoate

Parent: Enzalutamide

CAS No.: N/A

Cat No.: VE0016455

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Methyl 2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methylpropanoate

Parent: Enzalutamide

CAS No.: 1332524-01-2

Cat No.: VE0016352

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N-Desmethyl Enzalutamide

Parent: Enzalutamide

CAS No.: 1242137-16-1

Cat No.: VE006572

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N-Nitroso Enzalutamide

Parent: Enzalutamide

CAS No.: N/A

Cat No.: VE0022274

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N-Nitroso Enzalutamide Impurity 1

Parent: Enzalutamide

CAS No.: N/A

Cat No.: VE0024073

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1-(4-(methylcarbamoyl)-3-fluorophenyl)-3-(4-cyano-3-(trifluoromethyl)phenyl)thiourea

Parent: Enzalutamide

CAS No.: N/A

Cat No.: VE006575

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2-((3-fluoro-4-(methylcarbamoyl)phenyl)(nitroso)amino)-2-methylpropanoic acid

Parent: Enzalutamide

CAS No.: N/A

Cat No.: VE0016456

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2-((3-Fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methylpropanoic acid

Parent: Enzalutamide

CAS No.: 1289942-66-0

Cat No.: VE008224

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2-[3-Fluoro-4-(methyl carbonyl) phenyl amino]-2-methyl propanoic acid

Parent: Enzalutamide

CAS No.: N/A

Cat No.: VE0011809

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2-Fluoro-4-amino-N-methylbenzamide

Parent: Enzalutamide

CAS No.: N/A

Cat No.: VE0011808

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2-fluoro-N-methyl-4-(propan-2-ylideneamino)benzamide

Parent: Enzalutamide

CAS No.: N/A

Cat No.: VE0019943

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4-((2-carboxypropan-2-yl)(nitroso)amino)benzoic acid

Parent: Enzalutamide

CAS No.: N/A

Cat No.: VE0024897

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4-((2-cyanopropan-2-yl)(nitroso)amino)-N-methylbenzamide

Parent: Enzalutamide

CAS No.: N/A

Cat No.: VE0024873

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4-(3-(4-Cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-yl)-2-fluorobenzamide

Parent: Enzalutamide

CAS No.: 1242137-17-2

Cat No.: VE0027129

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4-Nitro-2-fluoro methyl benzamide

Parent: Enzalutamide

CAS No.: N/A

Cat No.: VE0011807

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Enzalutamide Related Compound

During the production and storage of Enzalutamide, related compounds and impurities may form, which must be controlled to ensure the drug’s safety and efficacy. Regulatory authorities, such as the U.S. Food and Drug Administration (FDA), provide strict guidelines on permissible impurity levels in Enzalutamide formulations.

Key aspects of Enzalutamide-related compounds and impurities include:

Related Substances: These are chemically similar compounds that may form during the synthesis of Enzalutamide. Monitoring these related substances is critical to maintain the medication’s safety and effectiveness.

Degradation Products: Enzalutamide may degrade over time due to exposure to environmental factors such as heat, light, or moisture. These degradation products can affect the drug’s stability and therapeutic potential.

Residual Solvents: Trace amounts of solvents used during manufacturing may remain in the final product. Regulatory standards ensure these are within permissible limits to guarantee patient safety.

Advanced analytical methods, such as High-Performance Liquid Chromatography (HPLC), are used to detect and quantify Enzalutamide-related compounds and impurities, ensuring compliance with stringent quality standards.

FAQ

Enzalutamide Impurities

Enzalutamide Carboxylic Acid

Enzalutamide Desfluoro Impurity

Enzalutamide Desfluoro N-Methyl Impurity

Enzalutamide Impurity 10

Enzalutamide Impurity 11

Enzalutamide Impurity 12

Enzalutamide Impurity 14

Enzalutamide Impurity 2

Enzalutamide Impurity 20

Enzalutamide Impurity 21

Enzalutamide Impurity 5

Enzalutamide Impurity 66

Enzalutamide Impurity 7

Enzalutamide Impurity F

Enzalutamide Inhouse Impurity L

Enzalutamide Inhouse Impurity O

Enzalutamide Mono Nitroso Methyl Ester

Enzalutamide Oxo Impurity

Enzalutamide Reference Standard

Ethyl 2-((3-fluoro-4-(methylcarbamoyl)phenyl)(nitroso)amino)-2-methylpropanoate

Ethyl 2-(4- (Methylcarbamoyl)-3-Fluoro Phenylamino)-2-Methyl propanoate

Methyl (4-cyano-3-(trifluoromethyl)phenyl)carbamodithioate

Methyl 2-((3-fluoro-4-(methylcarbamoyl)phenyl)(nitroso)amino)-2-methylpropanoate

Methyl 2-((3-fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methylpropanoate

N-Desmethyl Enzalutamide

N-Nitroso Enzalutamide

N-Nitroso Enzalutamide Impurity 1

1-(4-(methylcarbamoyl)-3-fluorophenyl)-3-(4-cyano-3-(trifluoromethyl)phenyl)thiourea

2-((3-fluoro-4-(methylcarbamoyl)phenyl)(nitroso)amino)-2-methylpropanoic acid

2-((3-Fluoro-4-(methylcarbamoyl)phenyl)amino)-2-methylpropanoic acid

2-[3-Fluoro-4-(methyl carbonyl) phenyl amino]-2-methyl propanoic acid

2-Fluoro-4-amino-N-methylbenzamide

2-fluoro-N-methyl-4-(propan-2-ylideneamino)benzamide

4-((2-carboxypropan-2-yl)(nitroso)amino)benzoic acid

4-((2-cyanopropan-2-yl)(nitroso)amino)-N-methylbenzamide

4-(3-(4-Cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-2,4-dioxoimidazolidin-1-yl)-2-fluorobenzamide

4-Nitro-2-fluoro methyl benzamide

Enzalutamide Related Compound

FAQ

Is Enzalutamide a form of chemotherapy?

What is the drug Enzalutamide used for?

What is the success rate of Enzalutamide?

What is the difference between Abiraterone and Enzalutamide?