Nortriptyline Impurities

A drug called nortriptyline is used to relieve nerve discomfort.

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Impurity structure Parent Drug Name Name of Impurity Catalogue No. CAS No.
Nortriptyline Impurity 1 (HCl Salt) Nortriptyline

Nortriptyline Impurity 1 (HCl Salt)

VE0019813 1750-07-8
Nortriptyline Impurity 3 (HCl Salt) Nortriptyline

Nortriptyline Impurity 3 (HCl Salt)

VE0019842 N/A
Nortriptyline-d3 Hydrochloride Nortriptyline

Nortriptyline-d3 Hydrochloride

DVE003 203784-52-5

Nortriptyline Related Compound

It’s occasionally used to treat melancholy and childhood bedwetting (nocturnal enuresis).



Is nortriptyline a muscle relaxant?

The current findings demonstrate that nortriptyline is useful in relaxing the vascular smooth muscle of human arteries that have been precontracted with KCl or noradrenaline. Amitriptyline and nortriptyline are also strong inhibitors of contractions brought on by neurogenic stimuli.

How is nortriptyline used for pain?

Nortriptyline reduces the number of pain signals that reach the brain by raising the number of particular nerve transmitters in the neurological system. It typically takes a week or so after starting nortriptyline for discomfort to start to subside.

What is the mechanism of action of nortriptyline?

Nortriptyline has antidepressant effects most likely by preventing serotonin and norepinephrine from being reabsorbed at neuronal cell membranes. By affecting the acetylcholine receptor, it also has antimuscarinic properties.