| Parent Drug Name | Name of Impurity | Catalogue No. | |
|---|---|---|---|
| Nortriptyline | Nortriptyline-d3 Hydrochloride | DVE003 | View CAS 203784-52-5 |
Nortriptyline Related Compound
It’s occasionally used to treat melancholy and childhood bedwetting (nocturnal enuresis).
References
- Vila, José M., et al. “Relaxant Effects of Antidepressants on Human Isolated Mesenteric Arteries.” British Journal of Clinical Pharmacology, vol. 48, no. 2, Wiley-Blackwell, Aug. 1999, pp. 223–29, https://doi.org/10.1046/j.1365-2125.1999.00002.x. Accessed 2 May 2023.
- and. “Nortriptyline | Health Navigator NZ.” Health Navigator New Zealand, Health Navigator New Zealand, 12 Aug. 2022, www.healthnavigator.org.nz/medicines/n/nortriptyline-for-persistent-pain/#:~:text=Nortriptyline%20works%20by%20increasing%20the,to%20begin%20to%20wear%20off. Accessed 2 May 2023.
- “Nortriptyline: Uses, Interactions, Mechanism of Action | DrugBank Online.” Drugbank.com, DrugBank, 2019, go.drugbank.com/drugs/DB00540. Accessed 2 May 2023.
FAQ
Is nortriptyline a muscle relaxant?
The current findings demonstrate that nortriptyline is useful in relaxing the vascular smooth muscle of human arteries that have been precontracted with KCl or noradrenaline. Amitriptyline and nortriptyline are also strong inhibitors of contractions brought on by neurogenic stimuli.
How is nortriptyline used for pain?
Nortriptyline reduces the number of pain signals that reach the brain by raising the number of particular nerve transmitters in the neurological system. It typically takes a week or so after starting nortriptyline for discomfort to start to subside.
What is the mechanism of action of nortriptyline?
Nortriptyline has antidepressant effects most likely by preventing serotonin and norepinephrine from being reabsorbed at neuronal cell membranes. By affecting the acetylcholine receptor, it also has antimuscarinic properties.
