Olmesartan Impurities

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Impurity structure Parent Drug Name Name of Impurity Catalogue No. CAS No.
Dehydro Olmesartan (HCl Salt) Olmesartan

Dehydro Olmesartan (HCl Salt)

VE0018438 N/A
Ethyl 4-(1-Hydroxy-1-methylethyl)-2- Propyl-Imidazole-5-Carboxylate Olmesartan

Ethyl 4-(1-Hydroxy-1-methylethyl)-2- Propyl-Imidazole-5-Carboxylate

VE0018465 144689-93-0
N-Alkylated Olmesartan Olmesartan

N-Alkylated Olmesartan

VL184009 1392475-91-0
Olmesartan Anhydro Acid N1-Trityl Ethyl Ester Olmesartan

Olmesartan Anhydro Acid N1-Trityl Ethyl Ester

VE009133 N/A
Olmesartan Dichloro Dimethyl trans-Isomer Olmesartan

Olmesartan Dichloro Dimethyl trans-Isomer

VE006827 116857-05-7
Olmesartan Dimer Ester Olmesartan

Olmesartan Dimer Ester

VL184007 1040250-19-8
Olmesartan Dimer Impurity Olmesartan

Olmesartan Dimer Impurity

VE0011115 1454571-97-1
Olmesartan EP Impurity A Olmesartan

Olmesartan EP Impurity A

VL184002 144689-24-7
Olmesartan EP Impurity B Olmesartan

Olmesartan EP Impurity B

VL184001 849206-43-5
Olmesartan EP Impurity C Olmesartan

Olmesartan EP Impurity C

VL184006 879562-26-2
Olmesartan EP Impurity D Olmesartan

Olmesartan EP Impurity D

VL184005 1020157-01-0
Olmesartan Ethyl Ester Olmesartan

Olmesartan Ethyl Ester

VL184003 144689-23-6
Olmesartan Ethyl Methyl Analog Olmesartan

Olmesartan Ethyl Methyl Analog

VL184013 1378863-74-1
Olmesartan Imidazole Diethyl Ester Impurity Olmesartan

Olmesartan Imidazole Diethyl Ester Impurity

VE0018421 144689-94-1
Olmesartan Impurity 1 Olmesartan

Olmesartan Impurity 1

VL184015 1392475-91-0
Olmesartan Impurity 11 Olmesartan

Olmesartan Impurity 11

VE0018423 114772-53-1
Olmesartan Impurity 12 Olmesartan

Olmesartan Impurity 12

VE006624 124750-51-2
Olmesartan Impurity 13 Olmesartan

Olmesartan Impurity 13

VE007058 172875-53-5
Olmesartan Impurity 17 Olmesartan

Olmesartan Impurity 17

VE0018425 144690-04-0
Olmesartan Impurity 19 Olmesartan

Olmesartan Impurity 19

VE0018426 1048948-15-7
Olmesartan Impurity 2 Olmesartan

Olmesartan Impurity 2

VE0016105 N/A
Olmesartan Impurity 2 Olmesartan

Olmesartan Impurity 2

VL184010 358685-13-9
Olmesartan Impurity 28 Olmesartan

Olmesartan Impurity 28

VE0018437 138804-35-0
Olmesartan Impurity 30 Olmesartan

Olmesartan Impurity 30

VE0018443 1227626-44-9
Olmesartan Impurity 31 Olmesartan

Olmesartan Impurity 31

VE0018444 2347585-74-2
Olmesartan Impurity 6 Olmesartan

Olmesartan Impurity 6

VE0011428 144690-07-3
Olmesartan Medoxomil Dimer Impurity Olmesartan

Olmesartan Medoxomil Dimer Impurity

VL184011 N/A
Olmesartan Medoxomil Impurity Olmesartan

Olmesartan Medoxomil Impurity

VE009848 80841-78-7
Olmesartan Medoxomil Impurity 10 Olmesartan

Olmesartan Medoxomil Impurity 10

VE0018435 2101308-73-8
Olmesartan Medoxomil Impurity 17 Olmesartan

Olmesartan Medoxomil Impurity 17

VE0018445 1418133-31-9
Olmesartan Medoxomil Impurity 3 Olmesartan

Olmesartan Medoxomil Impurity 3

VE0018461 1092980-84-1
Olmesartan Medoxomil Impurity 4 Olmesartan

Olmesartan Medoxomil Impurity 4

VE006921 95579-71-8
Olmesartan Medoxomil Impurity 7 Olmesartan

Olmesartan Medoxomil Impurity 7

VE0018462 2101308-74-9
Olmesartan Medoxomil Impurity 9 (HCl Salt) Olmesartan

Olmesartan Medoxomil Impurity 9 (HCl Salt)

VE0018463 N/A
Olmesartan Medoxomil Methyl Ether Olmesartan

Olmesartan Medoxomil Methyl Ether

VE0018467 896419-17-3
Olmesartan Methyl Ester Olmesartan

Olmesartan Methyl Ester

VE0018459 1347262-29-6
Olmesartan Trityl Alcohol Olmesartan

Olmesartan Trityl Alcohol

VL184004 76-84-6
Olmesartan-D4 Olmesartan

Olmesartan-D4

DVE001147 1420880-41-6
Trityl Olmesartan Olmesartan

Trityl Olmesartan

VL184016 144690-92-6
(4R,5S)-4,5-Dichloro-4,5-dimethyl-1,3-dioxolan-2-one Olmesartan

(4R,5S)-4,5-Dichloro-4,5-dimethyl-1,3-dioxolan-2-one

VE0011425 116857-04-6
(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-(2-hydroxypropan-2-yl)-1-((2'-(2-nitroso-2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-propyl-1H-imidazole-5-carboxylate Olmesartan

(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-(2-hydroxypropan-2-yl)-1-((2'-(2-nitroso-2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-propyl-1H-imidazole-5-carboxylate

VE0019903 N/A
4,5-Bis(chloromethyl)-1,3-dioxol-2-one Olmesartan

4,5-Bis(chloromethyl)-1,3-dioxol-2-one

VE008908 1443544-27-1

Olmesartan Related Compound

Olmesartan is a blood pressure medication (hypertension). Lowering blood pressure aids in the prevention of strokes, heart attacks, and renal disorders.

References

  • NHS Choices. Olmesartan. 2023, www.nhs.uk/medicines/olmesartan/.
  • ‌“Use of the Combination of Olmesartan and Hydrochlorothiazide in EssentialHypertensionFull Text View – ClinicalTrials.gov.” Clinicaltrials.gov,2019,clinicaltrials.gov/ct2/show/NCT004305

FAQ’s

Is Olmesartan an ACE inhibitor or a beta blocker?

Olmesartan may have an ACE inhibitory activity in addition to an Ang II receptor blocking action, preventing a rise in Ang II levels and protecting cardiovascular remodelling by increasing cardiac nitric oxide generation and endogenous Ang-(1-7) via ACE2 overexpression.

What combination is presented with Olmesartan?

Olmesartan medoxomil combined with hydrochlorothiazide

Why medoxomil combined with hydrochlorothiazide?

In moderate-to-severe hypertension, it improves 24-hour blood pressure management.