Oxaliplatin Impurities

Oxaliplatin is combined with other drugs to treat advanced colon or rectal cancer (cancer that begins in the large intestine).

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Impurity structure Parent Drug Name Name of Impurity Catalogue No. CAS No.
Oxaliplatin EP Impurity E Oxaliplatin

Oxaliplatin EP Impurity E

VE007026 N/A
Oxaliplatin Impurity 1 Oxaliplatin

Oxaliplatin Impurity 1

VE0018559 111263-58-2
Oxaliplatin Related Compound A (Dihydrate) Oxaliplatin

Oxaliplatin Related Compound A (Dihydrate)

VE0010682 6153-56-6
Oxaliplatin Related Compound B Oxaliplatin

Oxaliplatin Related Compound B

VE0010683 66900-68-3
Oxaliplatin Related Compound C Oxaliplatin

Oxaliplatin Related Compound C

VE0010684 111321-67-6
Oxaliplatin Related Compound D Oxaliplatin

Oxaliplatin Related Compound D

VE0010685 61758-77-8

Oxaliplatin Related Compound

Oxaliplatin is also used with other medications to prevent the spread of colon cancer in persons who have had surgery to remove the tumor.

References

OAndrĂ©, T., Boni, C., Navarro, M., Tabernero, J., Hickish, T., Topham, C., … & Haller, D. (2009). Improved overall survival with oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment in stage II or III colon cancer in the MOSAIC trial. Journal of clinical oncology, 27(19), 3109-3116. https://doi.org/10.1200/JCO.2008.20.6771

FAQ

How is oxaliplatin administered?

Oxaliplatin is typically administered intravenously (through a vein) in a hospital or clinic setting.

How does oxaliplatin work?

Oxaliplatin works by interfering with the DNA inside cancer cells, ultimately preventing them from dividing and growing. This leads to the death of cancer cells

What is the mechanism of action of oxaliplatin?

The mechanism of action of oxaliplatin involves the formation of DNA adducts, which interfere with DNA replication and ultimately lead to cancer cell death. Specifically, oxaliplatin forms covalent bonds with purine bases in DNA, leading to the formation of intrastrand and interstrand crosslinks, as well as DNA-protein crosslinks. These adducts cause DNA damage and activate cellular pathways that lead to cell cycle arrest, apoptosis, and autophagy.