Paroxetine Impurities

Paroxetine, a well-known selective serotonin reuptake inhibitor (SSRI), plays a pivotal role in managing and treating conditions like depression, anxiety disorders, OCD, and PTSD.

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Impurity structure Parent Drug Name Name of Impurity Catalogue No. CAS No.
Paroxetine EP Impurity B Paroxetine

Paroxetine EP Impurity B

VL1400004 533-31-3
Paroxetine EP Impurity D (HCl salt) Paroxetine

Paroxetine EP Impurity D (HCl salt)

VL1400002 130855-30-0
Paroxetine EP Impurity D-D4 Paroxetine

Paroxetine EP Impurity D-D4

DVE001230 N/A
Paroxetine EP Impurity E Paroxetine

Paroxetine EP Impurity E

VL1400001 105813-05-6
Paroxetine EP Impurity G Paroxetine

Paroxetine EP Impurity G

VL1400007 69675-10-1
Paroxetine EP Impurity J (HCl Salt) Paroxetine

Paroxetine EP Impurity J (HCl Salt)

VE008352 N/A
Paroxetine HCl Anhydrous EP Impurity F Paroxetine

Paroxetine HCl Anhydrous EP Impurity F

VE0015164 105813-39-6
Paroxetine HCl Anhydrous EP Impurity H Paroxetine

Paroxetine HCl Anhydrous EP Impurity H

VE006158 201855-60-9
Paroxetine HCl Anhydrous EP Impurity I Paroxetine

Paroxetine HCl Anhydrous EP Impurity I

VE006159 125224-43-3
Paroxetine HCl EP Impurity A (HCl salt) Paroxetine

Paroxetine HCl EP Impurity A (HCl salt)

VL1400005 1322626-23-2
Paroxetine HCl EP Impurity C (Free Base) Paroxetine

Paroxetine HCl EP Impurity C (Free Base)

VE006837 105813-14-7
Paroxetine HCl EP Impurity F (Free Base) Paroxetine

Paroxetine HCl EP Impurity F (Free Base)

VE006838 N/A
Paroxetine HCl Hemihydrate EP Impurity C (HCl salt) Paroxetine

Paroxetine HCl Hemihydrate EP Impurity C (HCl salt)

VL1400009 1346597-97-4
Paroxetine HCl Hemihydrate EP Impurity I Paroxol HCl Paroxetine

Paroxetine HCl Hemihydrate EP Impurity I Paroxol HCl

VE0015165 220548-73-2
Paroxetine Hemihydrate EP Impurity C Paroxetine

Paroxetine Hemihydrate EP Impurity C

VL1400003 1395408-54-4
Paroxetine Impurity 10 (HCl Salt) Paroxetine

Paroxetine Impurity 10 (HCl Salt)

VE0018684 N/A
Paroxetine Impurity 11 Paroxetine

Paroxetine Impurity 11

VE0018685 202534-94-9
Paroxetine Impurity 12 Paroxetine

Paroxetine Impurity 12

VE0018688 N/A
Paroxetine Impurity 18 Paroxetine

Paroxetine Impurity 18

VE0018691 105812-81-5
Paroxetine Impurity 23 (Mixture of Diastereomers) Paroxetine

Paroxetine Impurity 23 (Mixture of Diastereomers)

VE0018693 216690-19-6
Paroxetine N-Lactoside Paroxetine

Paroxetine N-Lactoside

VE0018776 N/A
Paroxetine Related Compound F Paroxetine

Paroxetine Related Compound F

VL1400006 110429-36-2
Paroxetine Related Compound G Paroxetine

Paroxetine Related Compound G

VE007335 1217655-87-2
Paroxetine-D4 (HCl Salt) Paroxetine

Paroxetine-D4 (HCl Salt)

DVE001218 2714485-95-5
Paroxetine-D6 (HCl Salt) (Mixture of Enantiomers) Paroxetine

Paroxetine-D6 (HCl Salt) (Mixture of Enantiomers)

DVE001219 N/A
Paroxol Methanesulfonate Paroxetine

Paroxol Methanesulfonate

VE0010626 608521-21-7
rac-trans-4-Defluoro-4-methoxy Paroxetine Hydrochloride Paroxetine

rac-trans-4-Defluoro-4-methoxy Paroxetine Hydrochloride

VE008914 127017-74-7
((3S,4R)-1-Methyl-4-phenylpiperidin-3-yl)methanol Paroxetine

((3S,4R)-1-Methyl-4-phenylpiperidin-3-yl)methanol

VE007287 176022-03-0
(3R,4R)-N-Methyl Paroxetine Paroxetine

(3R,4R)-N-Methyl Paroxetine

VE0018778 N/A
(3R,4R)-Paroxol Paroxetine

(3R,4R)-Paroxol

VE0018678 100332-12-5
(3S,4S)-N-Methyl Paroxetine Paroxetine

(3S,4S)-N-Methyl Paroxetine

VE0018777 N/A
(3S,4S)-Paroxol Paroxetine

(3S,4S)-Paroxol

VE0018676 100332-20-5

Paroxetine Related Compound

In the production of Paroxetine, impurities, often unwanted byproducts, can emerge. Ensuring the quantification, identification, and stringent control of these impurities is of utmost importance to uphold the efficacy, safety, and quality of the drug.

FAQ’s

What impurities are usually present in Paroxetine?

Various impurities such as residual solvents, starting materials, or degradation products can be found in Paroxetine.

How do impurities influence the effectiveness of Paroxetine?

Impurities can potentially compromise the drug’s potency, reliability, and safety, necessitating rigorous monitoring.