Pefloxacin is a synthetic broad-spectrum antibiotic belonging to the fluoroquinolone class. It is used to treat various bacterial infections, particularly those caused by Gram-negative organisms. It is effective in treating:
∙ Urinary tract infections (UTIs)
∙ Gastrointestinal infections
∙ Respiratory tract infections
∙ Skin and soft tissue infections
∙ Sexually transmitted infections (STIs)
Pefloxacin works by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes necessary for DNA replication and transcription, leading to bacterial cell death.
It is usually administered orally or intravenously and is concentrated well in tissues, making it effective for systemic infections.
Parent: Pefloxacin
Impurities in pefloxacin can arise from its synthetic process, photodegradation, or storage conditions, and must be controlled to meet ICH guidelines and ensure product quality.
Process-Related Impurities
Degradation Impurities
Elemental Impurities
Analytical Techniques for Impurity Detection
Pefloxacin is used to treat various infections such as:
Pefloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes required for DNA replication. This prevents bacterial multiplication and results in cell death, making it bactericidal.
Is pefloxacin still widely used?
Common side effects:
Serious but rare side effects:
Pefloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes required for DNA replication. This prevents bacterial multiplication and results in cell death, making it bactericidal.
