| Parent Drug Name | Name of Impurity | Catalogue No. | |
|---|---|---|---|
| Perindopril | Perindopril EP Impurity A | VL114001 | View CAS 80875-98-5 |
| Perindopril | Perindopril EP Impurity B | VL114002 | View CAS 95153-31-4 |
| Perindopril | Perindopril EP Impurity C | VL114005 | View CAS 129970-99-6 |
| Perindopril | Perindopril EP Impurity D | VL114006 | View CAS 130061-28-8 |
| Perindopril | Perindopril EP Impurity E | VL114003 | View CAS 1356837-89-2 |
| Perindopril | Perindopril EP Impurity F | VL114004 | View CAS 129970-98-5 |
| Perindopril | Perindopril EP Impurity G | VE009780 | View CAS 353777-66-9 |
| Perindopril | Perindopril EP Impurity H | VL114007 | View CAS 353777-64-7 |
| Perindopril | Perindopril EP Impurity I | VE006840 | View CAS 145513-33-3 |
| Perindopril | Perindopril EP Impurity J | VE0011316 | View CAS 685523-06-2 |
| Perindopril | Perindopril EP Impurity K | VL114008 | View CAS 2165676-00-4 |
| Perindopril | Perindopril Related Compound B (Monohydrate) | VE0010184 | View CAS 1418095-48-3 |
| Perindopril | Perindopril impurity | VL114009 | View CAS 145438-94-4 |
| Perindopril | Perindopril t-Butylamine | VE008342 | View CAS 107133-36-8 |
| Perindopril | (1R)-Perindopril tert-Butylamine Salt | VE009937 | View |
| Perindopril | (2S, 3aR, 7aR)-Octahydro-1H-indole-2-carboxylic Acid | VE009487 | View CAS 145513-90-2 |
| Perindopril | (2S, 3aS, 7aR)-Octahydro-1H-indole-2-carboxylic Acid | VE009486 | View CAS 145513-93-5 |
Perindopril Related Compound
Perindopril belongs to a family of drugs known as angiotensin-converting enzyme (ACE) inhibitors. It improves blood flow by reducing the formation of certain natural substances that constrict blood arteries.
References
- “Perindopril Arginine | DrugBank Online.” Drugbank.com, DrugBank, 2023, go.drugbank.com/salts/DBSALT001144. Accessed 28 Mar. 2023.
- Brichard S;Ketelslegers JM;Lambert AE. “Renal Function, Glycemic Control and Perindopril in Diabetic Patients.” Clinical and Experimental Hypertension. Part A, Theory and Practice, vol. 11 Suppl 2, Clin Exp Hypertens A, 2023, pubmed.ncbi.nlm.nih.gov/2691128/#:~:text=We%20conclude%20that%20perindopril%20normalizes,risk%20of%20developing%20diabetic%20nephropathy. Accessed 28 Mar. 2023.
FAQ
What is the therapeutic class of perindopril?
Perindopril is a nonsulfhydryl prodrug that belongs to the class of drugs known as angiotensin-converting enzyme (ACE) inhibitors.
What is the mechanism of action of perindopril?
ACE is a peptidyl dipeptidase that catalyzes the conversion of angiotensin I, an inactive decapeptide, to angiotensin II, a vasoconstrictor. Angiotensin II is a potent peripheral vasoconstrictor that increases adrenal cortex aldosterone production while providing negative feedback on renin secretion. Inhibiting ACE reduces plasma angiotensin II, which causes vasoconstriction, increased plasma renin activity, and reduced aldosterone production.
What function does perindopril serve in diabetes?
(Brichard S;Ketelslegers JM;Lambert AE) find that perindopril normalizes blood pressure in most hypertensive diabetic individuals without impairing diabetes management quality. It also causes a significant and consistent decrease in microalbuminuria in diabetic nephropathy patients.
