Perindopril Impurities

Perindopril is used to treat high blood pressure either alone or in combination with other drugs.

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Parent Drug Name Name of Impurity Catalogue No.
Perindopril Perindopril EP Impurity A VL114001View CAS 80875-98-5
Perindopril Perindopril EP Impurity B VL114002View CAS 95153-31-4
Perindopril Perindopril EP Impurity C VL114005View CAS 129970-99-6
Perindopril Perindopril EP Impurity D VL114006View CAS 130061-28-8
Perindopril Perindopril EP Impurity E VL114003View CAS 1356837-89-2
Perindopril Perindopril EP Impurity F VL114004View CAS 129970-98-5
Perindopril Perindopril EP Impurity G VE009780View CAS 353777-66-9
Perindopril Perindopril EP Impurity H VL114007View CAS 353777-64-7
Perindopril Perindopril EP Impurity I VE006840View CAS 145513-33-3
Perindopril Perindopril EP Impurity J VE0011316View CAS 685523-06-2
Perindopril Perindopril EP Impurity K VL114008View CAS 2165676-00-4
Perindopril Perindopril Related Compound B (Monohydrate) VE0010184View CAS 1418095-48-3
Perindopril Perindopril impurity VL114009View CAS 145438-94-4
Perindopril Perindopril t-Butylamine VE008342View CAS 107133-36-8
Perindopril (1R)-Perindopril tert-Butylamine Salt VE009937View
Perindopril (2S, 3aR, 7aR)-Octahydro-1H-indole-2-carboxylic Acid VE009487View CAS 145513-90-2
Perindopril (2S, 3aS, 7aR)-Octahydro-1H-indole-2-carboxylic Acid VE009486View CAS 145513-93-5

Perindopril Related Compound

Perindopril belongs to a family of drugs known as angiotensin-converting enzyme (ACE) inhibitors. It improves blood flow by reducing the formation of certain natural substances that constrict blood arteries.


  • “Perindopril Arginine | DrugBank Online.”, DrugBank, 2023, Accessed 28 Mar. 2023. ‌
  • Brichard S;Ketelslegers JM;Lambert AE. “Renal Function, Glycemic Control and Perindopril in Diabetic Patients.” Clinical and Experimental Hypertension. Part A, Theory and Practice, vol. 11 Suppl 2, Clin Exp Hypertens A, 2023,,risk%20of%20developing%20diabetic%20nephropathy. Accessed 28 Mar. 2023. ‌


What is the therapeutic class of perindopril?

Perindopril is a nonsulfhydryl prodrug that belongs to the class of drugs known as angiotensin-converting enzyme (ACE) inhibitors.

What is the mechanism of action of perindopril?

ACE is a peptidyl dipeptidase that catalyzes the conversion of angiotensin I, an inactive decapeptide, to angiotensin II, a vasoconstrictor. Angiotensin II is a potent peripheral vasoconstrictor that increases adrenal cortex aldosterone production while providing negative feedback on renin secretion. Inhibiting ACE reduces plasma angiotensin II, which causes vasoconstriction, increased plasma renin activity, and reduced aldosterone production.

What function does perindopril serve in diabetes?

(Brichard S;Ketelslegers JM;Lambert AE) find that perindopril normalizes blood pressure in most hypertensive diabetic individuals without impairing diabetes management quality. It also causes a significant and consistent decrease in microalbuminuria in diabetic nephropathy patients.

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(1R)-Perindopril tert-Butylamine Salt

(1R)-Perindopril tert-Butylamine Salt
Catalogue No.




Molecular Formula

C19H32N2O5. C4H11N

Molecular Weight

441.60 g/mol

Parent drug



2-methylpropan-2-amine (2S, 3aS, 7aS)-1-((S)-2-(((R)-1-ethoxy-1-oxopentan-2-yl)amino)propanoyl)octahydro-1H-indole-2-carboxylate







(1R)-Perindopril tert-Butylamine Salt

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