Perindopril Impurities

Perindopril is used to treat high blood pressure either alone or in combination with other drugs.

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Impurity structure Parent Drug Name Name of Impurity Catalogue No. CAS No.
Nitroso Perindopril EP impurity B Perindopril

Nitroso Perindopril EP impurity B

VE0012821 N/A
Perindopril Acyl-beta-D-Glucuronide Perindopril

Perindopril Acyl-beta-D-Glucuronide

VE0019094 120398-66-5
Perindopril EP Impurity A Perindopril

Perindopril EP Impurity A

VL114001 80875-98-5
Perindopril EP Impurity B Perindopril

Perindopril EP Impurity B

VL114002 95153-31-4
Perindopril EP Impurity B-D4 Perindopril

Perindopril EP Impurity B-D4

DVE001191 1356841-18-3
Perindopril EP Impurity C Perindopril

Perindopril EP Impurity C

VL114005 129970-99-6
Perindopril EP Impurity D Perindopril

Perindopril EP Impurity D

VL114006 130061-28-8
Perindopril EP Impurity E Perindopril

Perindopril EP Impurity E

VL114003 1356837-89-2
Perindopril EP Impurity F Perindopril

Perindopril EP Impurity F

VL114004 129970-98-5
Perindopril EP Impurity G Perindopril

Perindopril EP Impurity G

VE009780 353777-66-9
Perindopril EP Impurity H Perindopril

Perindopril EP Impurity H

VL114007 353777-64-7
Perindopril EP Impurity I Perindopril

Perindopril EP Impurity I

VE006840 145513-33-3
Perindopril EP Impurity I (t-Butylamine Salt) Perindopril

Perindopril EP Impurity I (t-Butylamine Salt)

VE0013844 N/A
Perindopril EP Impurity J Perindopril

Perindopril EP Impurity J

VE0011316 685523-06-2
Perindopril EP Impurity K Perindopril

Perindopril EP Impurity K

VL114008 2165676-00-4
Perindopril impurity Perindopril

Perindopril impurity

VL114009 145438-94-4
Perindopril Related Compound B (Monohydrate) Perindopril

Perindopril Related Compound B (Monohydrate)

VE0010184 1418095-48-3
Perindopril t-Butylamine Perindopril

Perindopril t-Butylamine

VE008342 107133-36-8
Perindopril tert-butylamine CRS (Y0000238) Perindopril

Perindopril tert-butylamine CRS (Y0000238)

PVE0085 107133-36-8
Perindopril-D4 Perindopril

Perindopril-D4

DVE001287 1356929-58-2
Perindoprilat Acyl-beta-D-Glucuronide Perindopril

Perindoprilat Acyl-beta-D-Glucuronide

VE0019096 120381-56-8
(1R)-Perindopril tert-Butylamine Salt Perindopril

(1R)-Perindopril tert-Butylamine Salt

VE009937 N/A
(2S,3aR,7aR)-Octahydro-1H-indole-2-carboxylic Acid Perindopril

(2S,3aR,7aR)-Octahydro-1H-indole-2-carboxylic Acid

VE009487 145513-90-2
(2S,3aS,7aR)-Octahydro-1H-indole-2-carboxylic Acid Perindopril

(2S,3aS,7aR)-Octahydro-1H-indole-2-carboxylic Acid

VE009486 145513-93-5

Perindopril Related Compound

Perindopril belongs to a family of drugs known as angiotensin-converting enzyme (ACE) inhibitors. It improves blood flow by reducing the formation of certain natural substances that constrict blood arteries.

References

  • “Perindopril Arginine | DrugBank Online.” Drugbank.com, DrugBank, 2023, go.drugbank.com/salts/DBSALT001144. Accessed 28 Mar. 2023. ‌
  • Brichard S;Ketelslegers JM;Lambert AE. “Renal Function, Glycemic Control and Perindopril in Diabetic Patients.” Clinical and Experimental Hypertension. Part A, Theory and Practice, vol. 11 Suppl 2, Clin Exp Hypertens A, 2023, pubmed.ncbi.nlm.nih.gov/2691128/#:~:text=We%20conclude%20that%20perindopril%20normalizes,risk%20of%20developing%20diabetic%20nephropathy. Accessed 28 Mar. 2023. ‌

FAQ

What is the therapeutic class of perindopril?

Perindopril is a nonsulfhydryl prodrug that belongs to the class of drugs known as angiotensin-converting enzyme (ACE) inhibitors.

What is the mechanism of action of perindopril?

ACE is a peptidyl dipeptidase that catalyzes the conversion of angiotensin I, an inactive decapeptide, to angiotensin II, a vasoconstrictor. Angiotensin II is a potent peripheral vasoconstrictor that increases adrenal cortex aldosterone production while providing negative feedback on renin secretion. Inhibiting ACE reduces plasma angiotensin II, which causes vasoconstriction, increased plasma renin activity, and reduced aldosterone production.

What function does perindopril serve in diabetes?

(Brichard S;Ketelslegers JM;Lambert AE) find that perindopril normalizes blood pressure in most hypertensive diabetic individuals without impairing diabetes management quality. It also causes a significant and consistent decrease in microalbuminuria in diabetic nephropathy patients.