Phentermine is a prescription appetite suppressant used to aid weight loss in obese or overweight individuals when combined with diet, exercise, and behavioral modification. It is chemically similar to amphetamine and belongs to the sympathomimetic amine class.
Phentermine works by stimulating the central nervous system (CNS), which increases heart rate and blood pressure and decreases appetite. It is typically prescribed for short-term use (a few weeks) due to the potential for tolerance and dependency.
It is marketed under several brand names, including Adipex-P, Suprenza, and in combination with topiramate as Qsymia.
Impurities in phentermine can result from the synthesis process, degradation, or formulation conditions, and must be controlled to meet ICH Q3A/B and pharmacopeial guidelines.
Process-Related Impurities
Degradation Impurities
Elemental Impurities
Analytical Techniques for Impurity Detection
ICP-MS for elemental impurities
Phentermine is used for:
Phentermine suppresses appetite by stimulating the release of norepinephrine, dopamine, and serotonin in the brain. This makes you feel full faster, reduces hunger, and increases energy expenditure.
Common side effects include:
Serious side effects:
