Polmacoxib Impurities

Polmacoxib is contraindicated in:

• Patients with known hypersensitivity to polmacoxib or other NSAIDs
• History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
• Active gastrointestinal bleeding or ulcers
• Severe hepatic or renal impairment
• History of cardiovascular events (e.g., heart attack, stroke), unless risk is carefully evaluated
  Always consult a healthcare provider before starting therapy.

Like other NSAIDs, polmacoxib may affect kidney function. Possible renal side effects include:

• Increased blood urea nitrogen (BUN) or creatinine levels
• Reduced glomerular filtration rate (GFR)
• Fluid retention or edema
• Risk of acute kidney injury, especially in elderly patients, those with pre-existing kidney disease, or on diuretics or ACE inhibitors
  Regular kidney function monitoring is advised during prolonged treatment.

• Drowsiness or sleepiness is not commonly reported with polmacoxib.
• However, some patients may experience fatigue, dizziness, or headache, which are listed as possible side effects.
• If sleepiness or altered alertness occurs, driving or operating machinery should be avoided.

• The duration of polmacoxib treatment depends on the severity of symptoms and individual response.
• It is typically prescribed for short- to medium-term relief of osteoarthritis symptoms.
• Long-term use should be approached cautiously due to potential cardiovascular and gastrointestinal risks, common to all COX-2 inhibitors.
• Patients on extended therapy should undergo regular monitoring.