Prothioconazole is a systemic triazole fungicide designed for foliar and seed treatment use with preventive and curative activity against a broad spectrum of ascomycete and basidiomycete pathogens. It is a member of the class of compounds triazoles, and possesses a unique toxophore in this class of fungicides. Its effective fungicidal properties can be attributed to its ability to inhibit CYP51A1. This enzyme is required to biosynthesize ergosterol, + some more technical info Prothioconazole binds the heme iron of the fungal 14alpha-demethylase CYP51A1, blocking conversion of C14-methylated sterol precursors to ergosterol and causing accumulation of toxic sterol intermediates that impair membrane integrity and sterol-dependent enzymes. The molecule is chiral and commercial material is a racemate; activity and metabolism are influenced by stereochemistry. Prothioconazole exhibits translaminar movement and limited acropetal translocation in plant tissue, is metabolized in planta mainly by oxidative desulfuration to the desthio metabolite and by subsequent hydrolytic steps, and shows good rainfastness when formulated as suspension concentrate or water dispersible granule. Typical use rates target control of septoria, rusts, ear rots and powdery mildew in cereals and other crops, and the compound is compatible with many tank mixes provided label sequences and adjuvant recommendations are followed.
Parent: Prothioconazole
Parent: Prothioconazole
Parent: Prothioconazole
Parent: Prothioconazole
Parent: Prothioconazole
Parent: Prothioconazole
Parent: Prothioconazole
Commercial technical prothioconazole is manufactured and released to specification with a high assay and controlled impurity profile to ensure efficacy and regulatory compliance. Typical technical grade specifications are assay in the range of 950 to 980 g/kg, individual specified related compounds generally limited to the range 1 to 20 g/kg depending on the impurity, and total related compounds not exceeding about 20 to 30 g/kg. Identified related compounds and impurities commonly monitored include prothioconazole-desthio (oxidative desulfurization product), prothioconazole-diol (secondary metabolite), residual synthetic intermediates and low level stereoisomeric impurities, plus routine limits for residual solvents and heavy metals. Specification sheets and certificates of analysis for each batch should be consulted for exact limits, individual impurity names and analytical methods, typically by HPLC with complementary MS or GC methods for volatile residues.
Prothioconazole is used as a broad spectrum systemic fungicide for protection and partial curative control of foliar diseases in cereals and selected other crops, and is also used in seed treatment formulations to protect emerging seedlings from soil and seedborne pathogens.
Prothioconazole is sold under various trade names depending on manufacturer and formulation; common commercial products combine prothioconazole with other actives or are marketed under proprietary brand names. Consult local registries or supplier documentation for brand names in your region.
Prothioconazole 20 tebuconazole 20 sc denotes a coformulated suspension concentrate containing 20 percent w/w prothioconazole and 20 percent w/w tebuconazole. The combination provides dual-site disease control leveraging the complementary spectra and modes of action of both triazoles, and is formulated as an SC for ease of dilution and spray application.
The industrial synthesis of prothioconazole involves multi step organic transformations from aromatic and triazole building blocks, including formation of the key carbon skeleton, installation of the triazole moiety, and final conversion to the nitrile or other terminating group depending on the analogue; process chemistry includes stereochemical control, purification by crystallization and distillation, and in process controls with HPLC and spectroscopic characterization to ensure low levels of specified impurities and consistent assay in the technical product.
