Quetiapine Impurities

Quetiapine is used to treat bipolar disorder (mania and depression) and schizophrenia.

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Parent Drug Name Name of Impurity Catalogue No.
Quetiapine Dibenzo[b, f][1, 4]thiazepin-11(10H)-one 5-oxide VE0011148View CAS 20290-48-6
Quetiapine N, N-dimethylaniline VL1260025View CAS 121-69-7
Quetiapine Phenyl [2-phenylthio)phenyl]carbamate VL1260023View CAS 111974-73-3
Quetiapine Quetiapine DBTP N-Methyl Impurity VL1260022View
Quetiapine Quetiapine Diether Alcohol Impurity VE007749View CAS 329216-69-5
Quetiapine Quetiapine Diether Alcohol Impurity (HCl Salt) VE006506View
Quetiapine Quetiapine EP Impurity A VL1260017View CAS 844639-07-2
Quetiapine Quetiapine EP Impurity B VL126002View CAS 111974-74-4
Quetiapine Quetiapine EP Impurity C VL126003View CAS 1798840-31-9
Quetiapine Quetiapine EP Impurity D VL126004View CAS 945668-94-0
Quetiapine Quetiapine EP Impurity E VE0010422View CAS 1371638-05-9
Quetiapine Quetiapine EP Impurity F VL126005View CAS 848814-27-7
Quetiapine Quetiapine EP Impurity G VL1260013View CAS 7/7/3159
Quetiapine Quetiapine EP Impurity H VL126007View CAS 1076199-40-0
Quetiapine Quetiapine EP Impurity I VL1260011View CAS 329216-67-3
Quetiapine Quetiapine EP Impurity I (2HCl Salt) VE007432View CAS 329218-14-6
Quetiapine Quetiapine EP Impurity I (Fumarate Salt) VE008248View
Quetiapine Quetiapine EP Impurity J VL126006View CAS 1356906-17-6
Quetiapine Quetiapine EP Impurity K VE0010423View CAS 1371638-10-6
Quetiapine Quetiapine EP Impurity L VE006068View CAS 1371638-11-7
Quetiapine Quetiapine EP Impurity N VE009091View CAS 1800291-86-4
Quetiapine Quetiapine EP Impurity N (HCl salt) VL1260012View
Quetiapine Quetiapine EP Impurity O VE006069View CAS 844639-06-1
Quetiapine Quetiapine EP Impurity P VL126009View CAS 1011758-03-4
Quetiapine Quetiapine EP Impurity Q VL1260010View
Quetiapine Quetiapine EP Impurity R VE0010424View CAS 2459-05-4
Quetiapine Quetiapine EP Impurity S VL126008View CAS 329216-63-9
Quetiapine Quetiapine EP Impurity S (HCl salt) VE006019View CAS 329218-11-3
Quetiapine Quetiapine EP Impurity T VL1260018View CAS 5747-46-6
Quetiapine Quetiapine EP Impurity U VE006070View CAS 5786-26-5
Quetiapine Quetiapine EP Impurity V VE006071View
Quetiapine Quetiapine EP Impurity W VE006072View CAS 1800608-95-0
Quetiapine Quetiapine Fumarate CRS (Y0001657) PVE00162View CAS 111974-72-2
Quetiapine Quetiapine HEEP Impurity VL1260019View CAS 13349-82-1
Quetiapine Quetiapine Hemifumarate Ester VE0011725View CAS 2209488-73-1
Quetiapine Quetiapine Quaternary Salt VL1260014View
Quetiapine 11-Chloro-dibenzo[b, f][1, 4]thiazepine VE008621View CAS 13745-86-3
Quetiapine 11-chlorodibenzo[b, f][1, 4]thiazepine 5, 5-dioxide VE0011939View
Quetiapine 11-chlorodibenzo[b, f][1, 4]thiazepine 5-oxide VE0011938View
Quetiapine 2 2 aminophenyl thio benzoic acid hydrochloride VL1260021View CAS 114724-41-3
Quetiapine 2-(2-chloroethoxy)ethanol VL1260026View CAS 628-89-7
Quetiapine 2-(Phenylthio)aniline VE0010198View CAS 1134-94-7
Quetiapine 2-Aminodiphenyl Sulfide Hydrochloride VE0012052View CAS 6764-13-2
Quetiapine 2-nitro diphenyl sulphide VL1260024View
Quetiapine 2-​[(2-​Aminophenyl)​sulfanyl]​benzonitrile VL1260020View CAS 140425-65-6

Quetiapine Related Compound

Quetiapine’s extended-release tablet is also used to treat major depressive disorder in combination with other antidepressants.


  • Hendrickson, Robert G., and Anthony P. Morocco. “Quetiapine Cross-Reactivity among Three Tricyclic Antidepressant Immunoassays.” Journal of Toxicology: Clinical Toxicology, vol. 41, no. 2, Jan. 2003, pp. 105–8, https://doi.org/10.1081/clt-120019122. Accessed 20 Mar. 2023.
  • Prieto. “Neurobiological Bases of Quetiapine Antidepressant Effect in the Bipolar Disorder.” Actas Espanolas de Psiquiatria, vol. 38, no. 1, Actas Esp Psiquiatr, 2021, pubmed.ncbi.nlm.nih.gov/20931407/#:~:text=Regarding%20the%20dopaminergic%20pathway%2C%20quetiapine,and%20antagonism%20of%20a2%20adrenoceptors. Accessed 20 Mar. 2023.
  • “Quetiapine: Uses, Interactions, Mechanism of Action | DrugBank Online.” Drugbank.com, DrugBank, 2014, go.drugbank.com/drugs/DB01224. Accessed 20 Mar. 2023. ‌


Is quetiapine a tricyclic antidepressant?

Quetiapine is a novel antipsychotic medication having structural similarities to tricyclic antidepressants (TCA). We present a case of a quetiapine overdose that originally resembled a TCA overdose and resulted in a false-positive TCA immunoassay.

Does quetiapine increase dopamine?

Quetiapine increases prefrontal dopamine release by antagonism of 5-HT2A receptors, a partial agonist of 5-HT1A receptors, and antagonism of a2 adrenoceptors.

What is the mechanism of action of quetiapine?

Quetiapine alleviates both positive and negative symptoms of schizophrenia and severe depression by acting on neurotransmitter receptors including serotonin and dopamine. It relieves both depressed and manic symptoms of bipolar illness.


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1011758-03-4 (base): Quetiapine EP Impurity P

1011758-03-4 (base): Quetiapine EP Impurity P
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Quetiapine N-Ethyl Analogue; Quetiapine N-Ethyl Impurity




Sci-Hub, Quetiapine Abuse Fourteen Years Later: Where Are We Now? A Systematic Review. Substance Use & Misuse, 1–10, 10.1080/10826084.2019.1668013. (2019). Sci-Hub.se. https://sci-hub.se/10.1080/10826084.2019.1668013




Quetiapine EP Impurity P

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