Quetiapine Impurities

Quetiapine is used to treat bipolar disorder (mania and depression) and schizophrenia.

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Impurity structure Parent Drug Name Name of Impurity Catalogue No. CAS No.
Dibenzo[b,f][1,4]thiazepin-11(10H)-one 5-oxide Quetiapine

Dibenzo[b,f][1,4]thiazepin-11(10H)-one 5-oxide

VE0011148 20290-48-6
N,N-dimethylaniline Quetiapine

N,N-dimethylaniline

VL1260025 121-69-7
Nitroso aryl piperazine-D8 Quetiapine

Nitroso aryl piperazine-D8

DVE001470 N/A
Phenyl [2-phenylthio)phenyl]carbamate Quetiapine

Phenyl [2-phenylthio)phenyl]carbamate

VL1260023 111974-73-3
Quetiapine DBTP N-Methyl Impurity Quetiapine

Quetiapine DBTP N-Methyl Impurity

VL1260022 N/A
Quetiapine Diether Alcohol Impurity Quetiapine

Quetiapine Diether Alcohol Impurity

VE007749 329216-69-5
Quetiapine Diether Alcohol Impurity (HCl Salt) Quetiapine

Quetiapine Diether Alcohol Impurity (HCl Salt)

VE006506 N/A
Quetiapine EP Impurity A Quetiapine

Quetiapine EP Impurity A

VL1260017 844639-07-2
Quetiapine EP Impurity B Quetiapine

Quetiapine EP Impurity B

VL126002 111974-74-4
Quetiapine EP Impurity C Quetiapine

Quetiapine EP Impurity C

VL126003 1798840-31-9
Quetiapine EP Impurity D Quetiapine

Quetiapine EP Impurity D

VL126004 945668-94-0
Quetiapine EP Impurity E Quetiapine

Quetiapine EP Impurity E

VE0010422 1371638-05-9
Quetiapine EP Impurity F Quetiapine

Quetiapine EP Impurity F

VL126005 848814-27-7
Quetiapine EP Impurity G Quetiapine

Quetiapine EP Impurity G

VL1260013 3159-07-7
Quetiapine EP Impurity H Quetiapine

Quetiapine EP Impurity H

VL126007 1076199-40-0
Quetiapine EP Impurity I Quetiapine

Quetiapine EP Impurity I

VL1260011 329216-67-3
Quetiapine EP Impurity I (2HCl Salt) Quetiapine

Quetiapine EP Impurity I (2HCl Salt)

VE007432 329218-14-6
Quetiapine EP Impurity I (Fumarate Salt) Quetiapine

Quetiapine EP Impurity I (Fumarate Salt)

VE008248 N/A
Quetiapine EP Impurity J Quetiapine

Quetiapine EP Impurity J

VL126006 1356906-17-6
Quetiapine EP Impurity K Quetiapine

Quetiapine EP Impurity K

VE0010423 1371638-10-6
Quetiapine EP Impurity L Quetiapine

Quetiapine EP Impurity L

VE006068 1371638-11-7
Quetiapine EP Impurity N Quetiapine

Quetiapine EP Impurity N

VE009091 1800291-86-4
Quetiapine EP Impurity N (HCl salt) Quetiapine

Quetiapine EP Impurity N (HCl salt)

VL1260012 N/A
Quetiapine EP Impurity O Quetiapine

Quetiapine EP Impurity O

VE006069 844639-06-1
Quetiapine EP Impurity P Quetiapine

Quetiapine EP Impurity P

VL126009 1011758-03-4
Quetiapine EP Impurity P (Fumarate) Quetiapine

Quetiapine EP Impurity P (Fumarate)

VE0017625 N/A
Quetiapine EP Impurity Q Quetiapine

Quetiapine EP Impurity Q

VL1260010 N/A
Quetiapine EP Impurity R Quetiapine

Quetiapine EP Impurity R

VE0010424 2459-05-4
Quetiapine EP Impurity S Quetiapine

Quetiapine EP Impurity S

VL126008 329216-63-9
Quetiapine EP Impurity S (HCl salt) Quetiapine

Quetiapine EP Impurity S (HCl salt)

VE006019 329218-11-3
Quetiapine EP Impurity T Quetiapine

Quetiapine EP Impurity T

VL1260018 5747-46-6
Quetiapine EP Impurity U Quetiapine

Quetiapine EP Impurity U

VE006070 5786-26-5
Quetiapine EP Impurity V Quetiapine

Quetiapine EP Impurity V

VE006071 N/A
Quetiapine EP Impurity W Quetiapine

Quetiapine EP Impurity W

VE006072 1800608-95-0
Quetiapine Ethyl Ether Impurity Quetiapine

Quetiapine Ethyl Ether Impurity

VE0019665 1011758-06-7
Quetiapine Fumarate CRS (Y0001657) Quetiapine

Quetiapine Fumarate CRS (Y0001657)

PVE00162 111974-72-2
Quetiapine HEEP Impurity Quetiapine

Quetiapine HEEP Impurity

VL1260019 13349-82-1
Quetiapine Hemifumarate Ester Quetiapine

Quetiapine Hemifumarate Ester

VE0011725 2209488-73-1
Quetiapine Impurity 13 (Chloride Salt) Quetiapine

Quetiapine Impurity 13 (Chloride Salt)

VE0019667 N/A
Quetiapine Impurity 19 Quetiapine

Quetiapine Impurity 19

VE0019668 116-50-7
Quetiapine O-Ethanol Impurity Quetiapine

Quetiapine O-Ethanol Impurity

VE0019664 N/A
Quetiapine Quaternary Salt Quetiapine

Quetiapine Quaternary Salt

VL1260014 N/A
Quetiapine-D4 (Hemifumarate Salt) Quetiapine

Quetiapine-D4 (Hemifumarate Salt)

DVE001417 1217310-65-0
Quetiapine-D8 (Fumarate Salt) Quetiapine

Quetiapine-D8 (Fumarate Salt)

DVE001416 N/A
11-Chloro-dibenzo[b,f][1,4]thiazepine Quetiapine

11-Chloro-dibenzo[b,f][1,4]thiazepine

VE008621 13745-86-3
11-chlorodibenzo[b,f][1,4]thiazepine 5-oxide Quetiapine

11-chlorodibenzo[b,f][1,4]thiazepine 5-oxide

VE0011938 N/A
11-chlorodibenzo[b,f][1,4]thiazepine 5,5-dioxide Quetiapine

11-chlorodibenzo[b,f][1,4]thiazepine 5,5-dioxide

VE0011939 N/A
2 2 aminophenyl thio benzoic acid hydrochloride Quetiapine

2 2 aminophenyl thio benzoic acid hydrochloride

VL1260021 114724-41-3
2-(2-chloroethoxy)ethanol Quetiapine

2-(2-chloroethoxy)ethanol

VL1260026 628-89-7
2-(Phenylthio)aniline Quetiapine

2-(Phenylthio)aniline

VE0010198 1134-94-7

Quetiapine Related Compound

Quetiapine’s extended-release tablet is also used to treat major depressive disorder in combination with other antidepressants.

References

  • Hendrickson, Robert G., and Anthony P. Morocco. “Quetiapine Cross-Reactivity among Three Tricyclic Antidepressant Immunoassays.” Journal of Toxicology: Clinical Toxicology, vol. 41, no. 2, Jan. 2003, pp. 105–8, https://doi.org/10.1081/clt-120019122. Accessed 20 Mar. 2023.
  • Prieto. “Neurobiological Bases of Quetiapine Antidepressant Effect in the Bipolar Disorder.” Actas Espanolas de Psiquiatria, vol. 38, no. 1, Actas Esp Psiquiatr, 2021, pubmed.ncbi.nlm.nih.gov/20931407/#:~:text=Regarding%20the%20dopaminergic%20pathway%2C%20quetiapine,and%20antagonism%20of%20a2%20adrenoceptors. Accessed 20 Mar. 2023.
  • “Quetiapine: Uses, Interactions, Mechanism of Action | DrugBank Online.” Drugbank.com, DrugBank, 2014, go.drugbank.com/drugs/DB01224. Accessed 20 Mar. 2023. ‌

FAQ

Is quetiapine a tricyclic antidepressant?

Quetiapine is a novel antipsychotic medication having structural similarities to tricyclic antidepressants (TCA). We present a case of a quetiapine overdose that originally resembled a TCA overdose and resulted in a false-positive TCA immunoassay.

Does quetiapine increase dopamine?

Quetiapine increases prefrontal dopamine release by antagonism of 5-HT2A receptors, a partial agonist of 5-HT1A receptors, and antagonism of a2 adrenoceptors.

What is the mechanism of action of quetiapine?

Quetiapine alleviates both positive and negative symptoms of schizophrenia and severe depression by acting on neurotransmitter receptors including serotonin and dopamine. It relieves both depressed and manic symptoms of bipolar illness.