|Parent Drug Name||Name of Impurity||Catalogue No.|
|Rifampicin||Desacetyl Rifampicin Quinone||VE0011704||View CAS 65110-92-1|
|Rifampicin||N-Demethyl Rifampicin||VE0011705||View CAS 13292-45-0|
|Rifampicin||Rifampicin||VE007986||View CAS 13292-46-1|
|Rifampicin||Rifampicin 21-O-Acetyl Analog||VE0011112||View CAS 1416773-22-2|
|Rifampicin||Rifampicin 23-O-Acetyl Analog||VE0011113||View CAS 1416773-23-3|
|Rifampicin||Rifampicin EP Impurity A||VL2760006||View CAS 13983-13-6|
|Rifampicin||Rifampicin EP Impurity B||VL2760001||View CAS 51963-55-4|
|Rifampicin||Rifamycin Impurity- 3(INHM)||VL2760007||View|
|Rifampicin||25-Desacetyl rifampicin||VL2760004||View CAS 16783-99-6|
|Rifampicin||25-Desacetyl-21-acetyl rifampicin||VL2760005||View CAS 1416773-22-2|
|Rifampicin||3-Formylrifamycin SV||VL2760003||View CAS 13292-22-3|
|Rifampicin||4-Methylpiperazine-1-yl-imino Rifamycin O||VE0010081||View|
Rifampicin Related Compound
Rifaximin belongs to the antibiotic drug class. Rifaximin cures traveler’s diarrhea and irritable bowel syndrome by inhibiting the development of the bacteria responsible for diarrhea.
- Saadi, Mohammed, and Richard W. McCallum. “Rifaximin in Irritable Bowel Syndrome: Rationale, Evidence and Clinical Use.” Therapeutic Advances in Chronic Disease, vol. 4, no. 2, Jan. 2013, pp. 71–75, https://doi.org/10.1177/2040622312472008. Accessed 14 Mar. 2023.
- DuPont, H. L. “Rifaximin: An Antibiotic with Important Biologic Effects.” Mini-Reviews in Medicinal Chemistry, vol. 16, no. 3, Nov. 2015, pp. 200–5, https://doi.org/10.2174/1389557515666150722110201. Accessed 14 Mar. 2023.
- “Rifaximin: Uses, Interactions, Mechanism of Action | DrugBank Online.” Drugbank.com, DrugBank, 2015, go.drugbank.com/drugs/DB01220. Accessed 14 Mar. 2023.
Why is rifaximin used in IBS?
The findings indicate that people with IBS have an overabundance of bacteria in the small bowel, a condition known as bacterial overgrowth. As a result, antibiotic-based therapies for IBS may be beneficial. Rifaximin is a nonabsorbable antibiotic with no clinically significant bacterial resistance.
Is rifaximin an anti-inflammatory?
The medicine possesses anti-inflammatory qualities that help to stabilize the gut mucosa, which is vital for its long-term benefits in non-infectious disorders. Rifaximin is used to treat hepatic encephalopathy and diarrhea-predominant irritable bowel syndrome on a long-term or recurring basis.
What is the mechanism of action of rifaximin?
Rifaximin inhibits RNA synthesis in sensitive bacteria by attaching to the beta subunit of the bacterial DNA-dependent ribonucleic acid (RNA) polymerase enzyme. Its binding prevents translocation and hence transcription.