Rifampicin Impurities

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Parent Drug Name Name of Impurity Catalogue No.
Rifampicin Desacetyl Rifampicin Quinone VE0011704View CAS 65110-92-1
Rifampicin N-Demethyl Rifampicin VE0011705View CAS 13292-45-0
Rifampicin N-Methyl Rifampicin VE0010080View
Rifampicin Rifampicin VE007986View CAS 13292-46-1
Rifampicin Rifampicin 21-O-Acetyl Analog VE0011112View CAS 1416773-22-2
Rifampicin Rifampicin 23-O-Acetyl Analog VE0011113View CAS 1416773-23-3
Rifampicin Rifampicin EP Impurity A VL2760006View CAS 13983-13-6
Rifampicin Rifampicin EP Impurity B VL2760001View CAS 51963-55-4
Rifampicin Rifamycin Impurity- 3(INHM) VL2760007View
Rifampicin 25-Desacetyl rifampicin VL2760004View CAS 16783-99-6
Rifampicin 25-Desacetyl-21-acetyl rifampicin VL2760005View CAS 1416773-22-2
Rifampicin 3-Formylrifamycin SV VL2760003View CAS 13292-22-3
Rifampicin 4-Methylpiperazine-1-yl-imino Rifamycin O VE0010081View

Rifampicin Related Compound

Rifaximin belongs to the antibiotic drug class. Rifaximin cures traveler’s diarrhea and irritable bowel syndrome by inhibiting the development of the bacteria responsible for diarrhea.

References

  • Saadi, Mohammed, and Richard W. McCallum. “Rifaximin in Irritable Bowel Syndrome: Rationale, Evidence and Clinical Use.” Therapeutic Advances in Chronic Disease, vol. 4, no. 2, Jan. 2013, pp. 71–75, https://doi.org/10.1177/2040622312472008. Accessed 14 Mar. 2023.
  • DuPont, H. L. “Rifaximin: An Antibiotic with Important Biologic Effects.” Mini-Reviews in Medicinal Chemistry, vol. 16, no. 3, Nov. 2015, pp. 200–5, https://doi.org/10.2174/1389557515666150722110201. Accessed 14 Mar. 2023. ‌
  • “Rifaximin: Uses, Interactions, Mechanism of Action | DrugBank Online.” Drugbank.com, DrugBank, 2015, go.drugbank.com/drugs/DB01220. Accessed 14 Mar. 2023. ‌

FAQ

Why is rifaximin used in IBS?

The findings indicate that people with IBS have an overabundance of bacteria in the small bowel, a condition known as bacterial overgrowth. As a result, antibiotic-based therapies for IBS may be beneficial. Rifaximin is a nonabsorbable antibiotic with no clinically significant bacterial resistance.

Is rifaximin an anti-inflammatory?

The medicine possesses anti-inflammatory qualities that help to stabilize the gut mucosa, which is vital for its long-term benefits in non-infectious disorders. Rifaximin is used to treat hepatic encephalopathy and diarrhea-predominant irritable bowel syndrome on a long-term or recurring basis.

What is the mechanism of action of rifaximin?

Rifaximin inhibits RNA synthesis in sensitive bacteria by attaching to the beta subunit of the bacterial DNA-dependent ribonucleic acid (RNA) polymerase enzyme. Its binding prevents translocation and hence transcription.

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13292-22-3: 3-Formylrifamycin SV

13292-22-3: 3-Formylrifamycin SV
Catalogue No.

VL2760003
CAS No.

13292-22-3
Molecular Formula

C38H47NO13
Molecular Weight

725.78
Parent drug

Rifampicin
IUPAC Name

1, 2-Dihydro-5, 6, 9, 17, 19, 21-hexahydroxy-23-methoxy-2, 4, 12, 16, 18, 20, 22-heptamethyl-1, 11-dioxo-2, 7-(epoxypentadeca[1, 11, 13]trienimino)naphtho[2, 1-b]furan-8-carboxaldehyde 21-acetate
Synonyms

1, 2-Dihydro-5, 6, 9, 17, 19, 21-hexahydroxy-23-methoxy-2, 4, 12, 16, 18, 20, 22-heptamethyl-1, 11-dioxo-2, 7-(epoxypentadeca[1, 11, 13]trienimino)naphtho[2, 1-b]furan-8-carboxaldehyde 21-Acetate; 3-Formylrifampicin SV; NCI 145-635; Rifaldehyde;
References

“Sci-Hub, Structure and Evaluation of Antibacterial and Antitubercular Properties of New Basic and Heterocyclic 3-Formylrifamycin SV Derivatives Obtained via ‘Click Chemistry’ Approach, 10.1016/J.ejmech.2014.07.066.” Hkvisa.net, 2014, sci-hub.hkvisa.net/10.1016/j.ejmech.2014.07.066.
Status

In-stock
ListName

3-Formylrifamycin SV
Exclusively Supplied by Veeprho

Exclusively Supplied by Veeprho

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