Rifampicin Impurities

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Rifampicin Related Compound

Rifaximin belongs to the antibiotic drug class. Rifaximin cures traveler’s diarrhea and irritable bowel syndrome by inhibiting the development of the bacteria responsible for diarrhea.


  • Saadi, Mohammed, and Richard W. McCallum. “Rifaximin in Irritable Bowel Syndrome: Rationale, Evidence and Clinical Use.” Therapeutic Advances in Chronic Disease, vol. 4, no. 2, Jan. 2013, pp. 71–75, https://doi.org/10.1177/2040622312472008. Accessed 14 Mar. 2023.
  • DuPont, H. L. “Rifaximin: An Antibiotic with Important Biologic Effects.” Mini-Reviews in Medicinal Chemistry, vol. 16, no. 3, Nov. 2015, pp. 200–5, https://doi.org/10.2174/1389557515666150722110201. Accessed 14 Mar. 2023. ‌
  • “Rifaximin: Uses, Interactions, Mechanism of Action | DrugBank Online.” Drugbank.com, DrugBank, 2015, go.drugbank.com/drugs/DB01220. Accessed 14 Mar. 2023. ‌


Why is rifaximin used in IBS?

The findings indicate that people with IBS have an overabundance of bacteria in the small bowel, a condition known as bacterial overgrowth. As a result, antibiotic-based therapies for IBS may be beneficial. Rifaximin is a nonabsorbable antibiotic with no clinically significant bacterial resistance.

Is rifaximin an anti-inflammatory?

The medicine possesses anti-inflammatory qualities that help to stabilize the gut mucosa, which is vital for its long-term benefits in non-infectious disorders. Rifaximin is used to treat hepatic encephalopathy and diarrhea-predominant irritable bowel syndrome on a long-term or recurring basis.

What is the mechanism of action of rifaximin?

Rifaximin inhibits RNA synthesis in sensitive bacteria by attaching to the beta subunit of the bacterial DNA-dependent ribonucleic acid (RNA) polymerase enzyme. Its binding prevents translocation and hence transcription.