| Parent Drug Name | Name of Impurity | Catalogue No. | |
|---|---|---|---|
| Ritonavir | Ritonavir EP Impurity A | VE006812 | View CAS 154212-61-0 |
| Ritonavir | Ritonavir EP Impurity A and Ritonavir EP Impurity B Mixture | VE006710 | View |
| Ritonavir | Ritonavir EP Impurity B | VE006814 | View CAS 765875-58-9 |
| Ritonavir | Ritonavir EP Impurity C | VE006700 | View CAS 1010808-43-1 |
| Ritonavir | Ritonavir EP Impurity D | VE006702 | View CAS 144142-33-6 |
| Ritonavir | Ritonavir EP Impurity E | VL860004 | View CAS 176655-56-4 |
| Ritonavir | Ritonavir EP Impurity F | VE005950 | View CAS 1010809-61-6 |
| Ritonavir | Ritonavir EP Impurity G | VL860001 | View CAS 2034136-66-6 |
| Ritonavir | Ritonavir EP Impurity H | VL860002 | View CAS 1010809-43-4 |
| Ritonavir | Ritonavir EP Impurity I | VL860006 | View CAS 165315-26-4 |
| Ritonavir | Ritonavir EP Impurity J | VE006813 | View CAS 162849-95-8 |
| Ritonavir | Ritonavir EP Impurity J & Ritonavir EP Impurity K Mixture | VE006712 | View |
| Ritonavir | Ritonavir EP Impurity K | VE006815 | View CAS 1010809-39-8 |
| Ritonavir | Ritonavir EP Impurity L | VE006706 | View CAS 256328-82-2 |
| Ritonavir | Ritonavir EP Impurity M | VE006707 | View |
| Ritonavir | Ritonavir EP Impurity N | VL860007 | View CAS 202816-62-4 |
| Ritonavir | Ritonavir EP Impurity O | VE006703 | View CAS 1414933-81-5 |
| Ritonavir | Ritonavir EP Impurity P | VL860005 | View |
| Ritonavir | Ritonavir EP Impurity Q | VL860009 | View |
| Ritonavir | Ritonavir EP Impurity R | VL860010 | View CAS 1414933-80-4 |
| Ritonavir | Ritonavir EP Impurity S | VL860011 | View CAS 2084828-53-3 |
| Ritonavir | Ritonavir EP Impurity T | VE006704 | View CAS 869368-48-9 |
| Ritonavir | Ritonavir EP Impurity U | VE006705 | View |
| Ritonavir | Ritonavir Impurity 2 | VE006709 | View CAS 144163-97-3 |
| Ritonavir | Ritonavir Impurity 23 | VE0010671 | View CAS 1004316-34-0 |
| Ritonavir | Ritonavir Impurity 3 | VE006711 | View CAS 534-07-6 |
| Ritonavir | Ritonavir Isoleucine Analog | VE006839 | View |
| Ritonavir | Ritonavir O-Aceyl Impurity | VL860003 | View CAS 959315-21-0 |
| Ritonavir | 4-Nitrophenyl Chloroformate | VE006708 | View CAS 7693-46-1 |
Ritonavir Related Compound
Ritonavir belongs to a class of drugs known as protease inhibitors. It works by lowering the level of HIV in the blood.
References
- Sevrioukova, I. F., and T. L. Poulos. “Structure and Mechanism of the Complex between Cytochrome P4503A4 and Ritonavir.” Proceedings of the National Academy of Sciences, vol. 107, no. 43, Oct. 2010, pp. 18422–27, https://doi.org/10.1073/pnas.1010693107. Accessed 29 Jan. 2020.
- Drewe, Jürgen, et al. “HIV Protease Inhibitor Ritonavir: A More Potent Inhibitor of P-Glycoprotein than the Cyclosporine Analog SDZ PSC 833.” Biochemical Pharmacology, vol. 57, no. 10, May 1999, pp. 1147–52, https://doi.org/10.1016/s0006-2952(99)00026-x. Accessed 16 Mar. 2023.
FAQ
What type of inhibitor is ritonavir?
Ritonavir is an HIV protease inhibitor that also effectively inhibits cytochrome P4503A4 (CYP3A4), the primary human drug-metabolizing enzyme.
Is ritonavir a P-gp inhibitor?
Drewe, Jürgen, et al. demonstrated that the HIV protease inhibitor ritonavir is a more powerful inhibitor of P-glycoprotein than the multidrug resistance (MDR)-reversing agent SDZ PSC.
Why is ritonavir used?
Ritonavir is used in combination with other medications to treat infections caused by the human immunodeficiency virus (HIV). The infection that causes acquired immune deficiency syndrome is HIV (AIDS). Ritonavir will not prevent or cure HIV infection or AIDS.
