Rosuvastatin Impurities

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Impurity structure Parent Drug Name Name of Impurity Catalogue No. CAS No.
N-Desmethyl Rosuvastatin Rosuvastatin

N-Desmethyl Rosuvastatin

VE0019432 371775-74-5
N-Nitroso Desmethyl Rosuvastatin (Ca Salt) Rosuvastatin

N-Nitroso Desmethyl Rosuvastatin (Ca Salt)

VE0020093 N/A
N-Nitroso-N-Desmethyl Rosuvastatin Rosuvastatin

N-Nitroso-N-Desmethyl Rosuvastatin

VE0019431 N/A
Rosuvastatin (3R,5R)-Isomer (Free Base) Rosuvastatin

Rosuvastatin (3R,5R)-Isomer (Free Base)

VE0010480 1094100-06-7
Rosuvastatin (3R,5R)-Isomer Calcium Rosuvastatin

Rosuvastatin (3R,5R)-Isomer Calcium

VE008031 1422515-55-6
Rosuvastatin (3R,5R)-Isomer t-Butyl Ester Rosuvastatin

Rosuvastatin (3R,5R)-Isomer t-Butyl Ester

VL127023 2162136-65-2
Rosuvastatin (3R,5S)-Isomer Methyl Ester Rosuvastatin

Rosuvastatin (3R,5S)-Isomer Methyl Ester

VE006590 N/A
Rosuvastatin (3S,5S)-Isomer t-Butyl Ester Rosuvastatin

Rosuvastatin (3S,5S)-Isomer t-Butyl Ester

VE0011885 2185805-16-5
Rosuvastatin (6R)-Isomer Calcium Salt Rosuvastatin

Rosuvastatin (6R)-Isomer Calcium Salt

VE009138 854898-49-0
Rosuvastatin (6R)-Isomer Sodium Salt Rosuvastatin

Rosuvastatin (6R)-Isomer Sodium Salt

VE008979 854898-48-9
Rosuvastatin (6R)-Lactone Impurity Rosuvastatin

Rosuvastatin (6R)-Lactone Impurity

VE008982 854898-46-7
Rosuvastatin (6S)-Lactone Impurity Rosuvastatin

Rosuvastatin (6S)-Lactone Impurity

VE008981 854898-47-8
Rosuvastatin 2,3-Anhydro Acid Rosuvastatin

Rosuvastatin 2,3-Anhydro Acid

VL127021 1422954-12-8
Rosuvastatin 3S 5S Isomer Rosuvastatin

Rosuvastatin 3S 5S Isomer

VL127007 N/A
Rosuvastatin 4,6-Diene Impurity Rosuvastatin

Rosuvastatin 4,6-Diene Impurity

VL127024 1422954-13-9
Rosuvastatin 5-Hydroxy-3-keto Rosuvastatin

Rosuvastatin 5-Hydroxy-3-keto

VL127033 1346606-28-7
Rosuvastatin 5-Oxo Acid t-Butyl Ester Rosuvastatin

Rosuvastatin 5-Oxo Acid t-Butyl Ester

VE008985 615556-96-2
Rosuvastatin Acetonide Carboxylic Acid Rosuvastatin

Rosuvastatin Acetonide Carboxylic Acid

VE006456 N/A
Rosuvastatin Acid Impurity Rosuvastatin

Rosuvastatin Acid Impurity

VL127020 1659301-59-3
Rosuvastatin Ally Ester Impurity Rosuvastatin

Rosuvastatin Ally Ester Impurity

VL127031 1352945-05-1
Rosuvastatin Anhydro Lactone Rosuvastatin

Rosuvastatin Anhydro Lactone

VL127032 1246665-85-9
Rosuvastatin Bromomethyl Impurity Rosuvastatin

Rosuvastatin Bromomethyl Impurity

VL127027 799842-07-2
Budesonide for System Suitability CRS (Y0001148) Rosuvastatin

Rosuvastatin Calcium (1606015)

PVE00371 147098-20-2
Rosuvastatin Calcium CRS (Y0001719) Rosuvastatin

Rosuvastatin Calcium CRS (Y0001719)

PVE00105 147098-20-2
Rosuvastatin EP Impurity A Rosuvastatin

Rosuvastatin EP Impurity A

VL127008 1714147-47-3
Rosuvastatin EP Impurity A (Sodium Salt) Rosuvastatin

Rosuvastatin EP Impurity A (Sodium Salt)

VE008146 1714147-50-8
Rosuvastatin EP Impurity B (Racemic Mixture) Rosuvastatin

Rosuvastatin EP Impurity B (Racemic Mixture)

VL127001 N/A
Rosuvastatin EP Impurity C Rosuvastatin

Rosuvastatin EP Impurity C

VL127003 1422514-05-3
Rosuvastatin EP Impurity C (Free Base) Rosuvastatin

Rosuvastatin EP Impurity C (Free Base)

VE0011116 1422619-13-3
Rosuvastatin EP Impurity D Rosuvastatin

Rosuvastatin EP Impurity D

VL127002 503610-43-3
Rosuvastatin EP Impurity E Rosuvastatin

Rosuvastatin EP Impurity E

VL127005 N/A
Rosuvastatin EP Impurity F Rosuvastatin

Rosuvastatin EP Impurity F

VL127004 289042-12-2
Rosuvastatin EP Impurity G Rosuvastatin

Rosuvastatin EP Impurity G

VL127009 N/A
Rosuvastatin EP Impurity G (Free Base) Rosuvastatin

Rosuvastatin EP Impurity G (Free Base)

VE008147 1242184-42-4
Rosuvastatin EP Impurity H Rosuvastatin

Rosuvastatin EP Impurity H

VL127015 1335110-44-5
Rosuvastatin EP Impurity I (Sodium Salt) Rosuvastatin

Rosuvastatin EP Impurity I (Sodium Salt)

VL127016 N/A
Rosuvastatin EP Impurity J Rosuvastatin

Rosuvastatin EP Impurity J

VL127014 N/A
Rosuvastatin EP Impurity K Rosuvastatin

Rosuvastatin EP Impurity K

VL127017 N/A
Rosuvastatin EP Impurity L Rosuvastatin

Rosuvastatin EP Impurity L

VL127006 1024064-70-7
Rosuvastatin EP Impurity M Rosuvastatin

Rosuvastatin EP Impurity M

VL127018 N/A
Rosuvastatin EP Impurity M (Free Base) Rosuvastatin

Rosuvastatin EP Impurity M (Free Base)

VE006725 N/A
Rosuvastatin Ethyl Ester Impurity Rosuvastatin

Rosuvastatin Ethyl Ester Impurity

VL127022 851443-04-4
Budesonide for System Suitability CRS (Y0001148) Rosuvastatin

Rosuvastatin for Impurity L Identification CRS (Y0002146)

PVE00309 N/A
Budesonide for System Suitability CRS (Y0001148) Rosuvastatin

Rosuvastatin for System Suitability CRS (Y0001721)

PVE0081 147098-20-2
Rosuvastatin Formyl Impurity Rosuvastatin

Rosuvastatin Formyl Impurity

VL127025 147118-37-4
Rosuvastatin FP Impurity B Rosuvastatin

Rosuvastatin FP Impurity B

VE006136 287714-41-4
Rosuvastatin Hydroxy methyl Impurity Rosuvastatin

Rosuvastatin Hydroxy methyl Impurity

VL127026 147118-36-3
Rosuvastatin Hydroxy propenyl Impurity Rosuvastatin

Rosuvastatin Hydroxy propenyl Impurity

VL127028 910867-08-2
Rosuvastatin Impurity 29 Rosuvastatin

Rosuvastatin Impurity 29

VE0018016 799842-06-1
Rosuvastatin Impurity 4 Rosuvastatin

Rosuvastatin Impurity 4

VE0013993 124655-09-0

Rosuvastatin Related Compound

It works by inhibiting an enzyme required by the body to produce cholesterol, hence lowering the quantity of cholesterol in the blood.

References

  • “Rosuvastatin: MedlinePlus Drug Information.” Medlineplus.gov, 2021, www.medlineplus.gov/druginfo/meds/a603033.html. Accessed 20 Feb. 2023.
  • Lee, Sungjae, et al. “Antihypertensive Effects of Rosuvastatin in Patients with Hypertension and Dyslipidemia: A Systemic Review and Meta-Analysis of Randomized Studies.” PLOS ONE, edited by Mansueto Gomes Neto, vol. 16, no. 11, Nov. 2021, p. e0260391, https://doi.org/10.1371/journal.pone.0260391. Accessed 20 Feb. 2023.

FAQ’s

Rosuvastatin belongs to which family ?

Rosuvastatin belongs to a family of drugs known as HMG-CoA reductase inhibitors (statins).

Is rosuvastatin A an antihypertensive medication?

Rosuvastatin may help manage hypertension and, as a result, reduce the risk of cardiovascular events in people with hypertension and dyslipidemia.

What is the mechanism action of Rosuvastatin?

Rosuvastatin belongs to a family of drugs known as HMG-CoA reductase inhibitors (statins). It works by delaying the creation of cholesterol in the body, reducing the amount of cholesterol that can build up on the artery walls and obstruct blood flow to the heart, brain, and other organs.