| Parent Drug Name | Name of Impurity | Catalogue No. | |
|---|---|---|---|
| Sacubitril | Sacubitril (2R, 4R)-Isomer | VE005968 | View CAS 766480-48-2 |
| Sacubitril | Sacubitril (2S, 4S)-Isomer | VE005967 | View CAS 149709-63-7 |
| Sacubitril | Sacubitril (3R, 5S) Pyrrolidinone Impurity | VE005969 | View CAS 1038924-70-7 |
| Sacubitril | Sacubitril (3S, 5S)-Pyrrolidinone | VE009210 | View CAS 1038925-00-6 |
| Sacubitril | Sacubitril AHU-66 | VE009417 | View CAS 1426129-50-1 |
| Sacubitril | Sacubitril Acid Impurity | VL3730004 | View |
| Sacubitril | Sacubitril Desethyl Impurity | VE005973 | View CAS 149709-44-4 |
| Sacubitril | Sacubitril Isopropyl Ester Impurity | VL3730003 | View |
| Sacubitril | Sacubitril Methyl ester | VE005972 | View CAS 2408053-56-3 |
| Sacubitril | Sacubitril Pyrrolidinone Impurity | VL3730005 | View CAS 2101222-51-7 |
| Sacubitril | Sacubitril SBT Diastereomer Impurity | VL3730001 | View |
| Sacubitril | Sacubitril SBT Enantiomer | VL3730002 | View |
| Sacubitril | Sacubitril-(2R, 4R)-Isomer | VE0010483 | View CAS 2259708-00-2 |
| Sacubitril | Sacubutril impurity 11 | VE005971 | View CAS 1038924-71-8 |
| Sacubitril | Sacubutril impurity 9 | VE005970 | View CAS 149690-12-0 |
| Sacubitril | 2, 5-Dioxopyrrolidine Sacubitril | VE009209 | View CAS 1038924-97-8 |
| Sacubitril | (2R, 4S)-4-amino-2-methyl-5-(4-phenylphenyl)pentanoic acid | VE009679 | View CAS 1039307-95-3 |
| Sacubitril | (2R, 4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic Acid | VE009680 | View CAS 1012341-50-2 |
| Sacubitril | (2R, 4S)-5-([1, 1'-biphenyl]-4-yl)-4-(3-carboxypropanamido)-2-methylpentanoic acid | VE009690 | View |
| Sacubitril | (2R, 4S)-5-biphenyl-4yl-4-(3-carboxy-acryloylamino)-2-methyl-pentonic acid ethyl ester | VE0010786 | View |
| Sacubitril | (2S, 4R)-5-([1, 1'-Biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic Acid | VE0011292 | View CAS 1012341-54-6 |
| Sacubitril | (2S, 4R)-Sacubitril | VE009208 | View CAS 761373-05-1 |
| Sacubitril | (3R, 5S)-3-methyl-5-(biphenyl-4-yl)pyrrolidin-2-one | VE0010752 | View |
| Sacubitril | (E)-(R)-5-Biphenyl-4-yl-4-(3-carboxypropionylamino)-2-methyl-pent-2-enoic acid ethyl ester | VE009773 | View |
Sacubitril Related Compound
Sacubitril is the first medicine in a new family of pharmaceuticals known as angiotensin receptor neprilysin inhibitors (ARNI). The medicine is intended to be used to treat individuals with chronic heart failure with reduced ejection fraction (HFrEF) who are in NYHA class II, III, or IV.
References
- “Valsartan and Sacubitril: MedlinePlus Drug Information.” Medlineplus.gov, 2020, medlineplus.gov/druginfo/meds/a615039.html#:~:text=Sacubitril%20is%20in%20a%20class,to%20help%20control%20blood%20volume. Accessed 8 Mar. 2023.
- Iborra-Egea, Oriol, et al. “Mechanisms of Action of Sacubitril/Valsartan on Cardiac Remodeling: A Systems Biology Approach.” Npj Systems Biology and Applications, vol. 3, no. 1, Apr. 2017, https://doi.org/10.1038/s41540-017-0013-4. Accessed 8 Mar. 2023.
- “Caution Needed When Interpreting BNP in Sacubitril/Valsartan Treatment.” Mass General Advances in Motion, 3 Sept. 2020, advances.massgeneral.org/cardiovascular/journal.aspx?id=1656#:~:text=In%20the%20pivotal%20PARADIGM%2DHF,a%20slight%20subsequent%20downward%20trend. Accessed 8 Mar. 2023.
FAQ
What class of drug is sacubitril?
Sacubitril belongs to a class of drugs known as neprilysin inhibitors. It aids in the regulation of blood volume.
What is the mechanism of action of sacubitril?
Sacubitril, on the other hand, works by blocking the breakdown of endogenous vasoactive peptides such as natriuretic peptides (ANP, BNP, and CNP), hence decreasing myocardial cell death.
Does sacubitril increase BNP?
The beginning of sacubitril resulted in elevated BNP concentrations. The elevations were minor, with a little subsequent downward tendency.
![(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-(3-carboxypropanamido)-2-methylpentanoic acid](https://veeprho.com/wp-content/uploads/2022/08/2R-4S-5-1-1-biphenyl-4-yl-4-3-carboxypropanamido-2-methylpentanoic-acid.png)