Sacubitril Impurities

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Parent Drug Name Name of Impurity Catalogue No.
Sacubitril Sacubitril (2R, 4R)-Isomer VE005968View CAS 766480-48-2
Sacubitril Sacubitril (2S, 4S)-Isomer VE005967View CAS 149709-63-7
Sacubitril Sacubitril (3R, 5S) Pyrrolidinone Impurity VE005969View CAS 1038924-70-7
Sacubitril Sacubitril (3S, 5S)-Pyrrolidinone VE009210View CAS 1038925-00-6
Sacubitril Sacubitril AHU-66 VE009417View CAS 1426129-50-1
Sacubitril Sacubitril Acid Impurity VL3730004View
Sacubitril Sacubitril Desethyl Impurity VE005973View CAS 149709-44-4
Sacubitril Sacubitril Isopropyl Ester Impurity VL3730003View
Sacubitril Sacubitril Methyl ester VE005972View CAS 2408053-56-3
Sacubitril Sacubitril Pyrrolidinone Impurity VL3730005View CAS 2101222-51-7
Sacubitril Sacubitril SBT Diastereomer Impurity VL3730001View
Sacubitril Sacubitril SBT Enantiomer VL3730002View
Sacubitril Sacubitril-(2R, 4R)-Isomer VE0010483View CAS 2259708-00-2
Sacubitril Sacubutril impurity 11 VE005971View CAS 1038924-71-8
Sacubitril Sacubutril impurity 9 VE005970View CAS 149690-12-0
Sacubitril 2, 5-Dioxopyrrolidine Sacubitril VE009209View CAS 1038924-97-8
Sacubitril (2R, 4S)-4-amino-2-methyl-5-(4-phenylphenyl)pentanoic acid VE009679View CAS 1039307-95-3
Sacubitril (2R, 4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic Acid VE009680View CAS 1012341-50-2
Sacubitril (2R, 4S)-5-([1, 1'-biphenyl]-4-yl)-4-(3-carboxypropanamido)-2-methylpentanoic acid VE009690View
Sacubitril (2R, 4S)-5-biphenyl-4yl-4-(3-carboxy-acryloylamino)-2-methyl-pentonic acid ethyl ester VE0010786View
Sacubitril (2S, 4R)-5-([1, 1'-Biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic Acid VE0011292View CAS 1012341-54-6
Sacubitril (2S, 4R)-Sacubitril VE009208View CAS 761373-05-1
Sacubitril (3R, 5S)-3-methyl-5-(biphenyl-4-yl)pyrrolidin-2-one VE0010752View
Sacubitril (E)-(R)-5-Biphenyl-4-yl-4-(3-carboxypropionylamino)-2-methyl-pent-2-enoic acid ethyl ester VE009773View

Sacubitril Related Compound

Sacubitril is the first medicine in a new family of pharmaceuticals known as angiotensin receptor neprilysin inhibitors (ARNI). The medicine is intended to be used to treat individuals with chronic heart failure with reduced ejection fraction (HFrEF) who are in NYHA class II, III, or IV.


  • “Valsartan and Sacubitril: MedlinePlus Drug Information.”, 2020,,to%20help%20control%20blood%20volume. Accessed 8 Mar. 2023.
  • Iborra-Egea, Oriol, et al. “Mechanisms of Action of Sacubitril/Valsartan on Cardiac Remodeling: A Systems Biology Approach.” Npj Systems Biology and Applications, vol. 3, no. 1, Apr. 2017, Accessed 8 Mar. 2023.
  • “Caution Needed When Interpreting BNP in Sacubitril/Valsartan Treatment.” Mass General Advances in Motion, 3 Sept. 2020,,a%20slight%20subsequent%20downward%20trend. Accessed 8 Mar. 2023. ‌


What class of drug is sacubitril?

Sacubitril belongs to a class of drugs known as neprilysin inhibitors. It aids in the regulation of blood volume.

What is the mechanism of action of sacubitril?

Sacubitril, on the other hand, works by blocking the breakdown of endogenous vasoactive peptides such as natriuretic peptides (ANP, BNP, and CNP), hence decreasing myocardial cell death.

Does sacubitril increase BNP?

The beginning of sacubitril resulted in elevated BNP concentrations. The elevations were minor, with a little subsequent downward tendency.

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(2R,4S)-5-([1,1′-biphenyl]-4-yl)-4-(3-carboxypropanamido)-2-methylpentanoic acid

(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-(3-carboxypropanamido)-2-methylpentanoic acid
Catalogue No.




Molecular Formula


Molecular Weight

383.44 g/mol

Parent drug



(2R, 4S)-5-([1, 1'-biphenyl]-4-yl)-4-(3-carboxypropanamido)-2-methylpentanoic acid







(2R, 4S)-5-([1, 1'-biphenyl]-4-yl)-4-(3-carboxypropanamido)-2-methylpentanoic acid

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