Sacubitril is an antihypertensive drug used primarily for the treatment of chronic heart failure. It is part of the class of drugs known as neprilysin inhibitors. It works by increasing the levels of certain proteins in the body that can dilate blood vessels, resulting in lower blood pressure, allowing the heart to pump more efficiently. Sacubitril often works in combination with valsartan, an angiotensin receptor blocker. The combination drug, sacubitril/valsartan, was known during clinical trials as LCZ696 and is now marketed under the brand name Entresto.
![Disodium, (2R,4S)-5-([1,1'- biphenyl]-4-yl)-4-(3- carboxypropanamido)-2-methylvalerate](https://veeprho.com/wp-content/uploads/2026/01/Disodium-2R4S-5-11-biphenyl-4-yl-4-3-carboxypropanamido-2-methylvalerate-NA-VE0026765-bc8d.png "Disodium, (2R,4S)-5-([1,1'- biphenyl]-4-yl)-4-(3- carboxypropanamido)-2-methylvalerate")
Parent: Sacubitril
Parent: Sacubitril
Parent: Sacubitril
Parent: Sacubitril
Parent: Sacubitril
Parent: Sacubitril
Parent: Sacubitril
Parent: Sacubitril
Parent: Sacubitril
Parent: Sacubitril/ Sacubitril Sodium
![(2R,4R)-5-([1,1-Biphenyl]-4-yl)-4-(tert-butoxycarbonyl)amino-2-methylpentanoic acid](https://veeprho.com/wp-content/uploads/2025/03/VE0023211-2R-4R-5-1-1-Biphenyl-4-yl-4-tert-butoxycarbonyl-amino-2-methylpentanoic-acid.png "(2R,4R)-5-([1,1-Biphenyl]-4-yl)-4-(tert-butoxycarbonyl)amino-2-methylpentanoic acid")
Parent: Sacubitril
Parent: Sacubitril
Parent: Sacubitril
![(2R,4S)-5-(biphenyl-4 yl)[(tertbutoxycarbonyl)amino]-2 methyl pentanoic acid ethyl ester](https://veeprho.com/wp-content/uploads/2024/11/VE0022232-2R-4S-5-biphenyl-4-yl-tertbutoxycarbonyl-amino-2-methyl-pentanoic-acid-ethyl-ester.png "(2R,4S)-5-(biphenyl-4 yl)[(tertbutoxycarbonyl)amino]-2 methyl pentanoic acid ethyl ester")
Parent: Sacubitril
![(2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic Acid](https://veeprho.com/wp-content/uploads/2026/02/2R4S-5-Biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methylpentanoic-Acid-1012341-50-2-VE009680-ac14.png "(2R,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic Acid")
Parent: Sacubitril
Parent: Sacubitril
![(2R,4S)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoate](https://veeprho.com/wp-content/uploads/2023/11/VE0016600-2R-4S-ethyl-5-1-1-biphenyl-4-yl-4-amino-2-methylpentanoate.png "(2R,4S)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoate")
Parent: Sacubitril
![(2S,4R)-5-([1,1'-Biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic Acid](https://veeprho.com/wp-content/uploads/2023/03/2S-4R-5-1-1-Biphenyl-4-yl-4-tert-butoxycarbonyl-amino-2-methylpentanoic-Acid.png "(2S,4R)-5-([1,1'-Biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic Acid")
Parent: Sacubitril
Parent: Sacubitril
Parent: Sacubitril
Parent: Sacubitril
![(R,E)-5-([1,1-Biphenyl]-4-Yl)-4-((Tert-Butoxycarbonyl)Amino)-2-Methylpent-2-Enoic Acid](https://veeprho.com/wp-content/uploads/2024/05/R-E-5-1-1-Biphenyl-4-Yl-4-Tert-Butoxycarbonyl-Amino-2-Methylpent-2-Enoic-Acid.png "(R,E)-5-([1,1-Biphenyl]-4-Yl)-4-((Tert-Butoxycarbonyl)Amino)-2-Methylpent-2-Enoic Acid")
Parent: Sacubitril
Parent: Sacubitril
Parent: Sacubitril
![2-Methylpropan-2-aminium (E)-4-(((2R,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobut-2-enoate](https://veeprho.com/wp-content/uploads/2026/04/2-Methylpropan-2-aminium-E-4-2R4R-1-11-biphenyl-4-yl-5-ethoxy-4-methyl-5-oxopentan-2-ylamino-4-oxobut-2-enoate-NA-VE0028695.png "2-Methylpropan-2-aminium (E)-4-(((2R,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobut-2-enoate")
Parent: Sacubitril
![2-methylpropan-2-aminium 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-methoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate](https://veeprho.com/wp-content/uploads/2026/04/2-methylpropan-2-aminium-4-2S4R-1-11-biphenyl-4-yl-5-methoxy-4-methyl-5-oxopentan-2-ylamino-4-oxobutanoate-NA-VE0028696.png "2-methylpropan-2-aminium 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-methoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate")
Parent: Sacubitril
Parent: Sacubitril
The manufacturing process of Sacubitril might lead to the formation of impurities and related compounds. These impurities often occur in trace amounts and include desethyl sacubitril, sacubitrilat and P88 or desethyl sacubitrilat. The impurities can have a potential impact on the efficacy and safety of the drug and thus, it is crucial to monitor and control the levels of these impurities in the drug product. Typically, the acceptable amount of Sacubitril impurities and related compounds is determined based on the guidelines provided by regulatory agencies such as the Food and Drug Administration (FDA).
Sacubitril is used in combination with valsartan for the treatment of chronic heart failure. It helps lower blood pressure and allows the heart to pump blood more efficiently.
No, Sacubitril is not a diuretic. It’s a neprilysin inhibitor that works by increasing the levels of certain proteins in the body that can dilate blood vessels, thereby helping to lower blood pressure.
Yes, Sacubitril has vasodilator effects. It increases the levels of certain proteins in the body that can dilate blood vessels which helps lower the blood pressure.
No, Sacubitril and Valsartan are not the same. While they are often used together in a combination drug to treat heart failure, they work in different ways. Sacubitril is a neprilysin inhibitor, while Valsartan is an angiotensin receptor blocker.
