Sitagliptin Impurities

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Parent Drug Name Name of Impurity Catalogue No.
Sitagliptin Methyl 3-oxo-4-(2, 4, 5-trifluorophenyl)butanoate VE009010View CAS 769195-26-8
Sitagliptin Methyl 4-(2, 4-difluorophenyl)-3-oxobutanoate VE009113View
Sitagliptin Methyl 4-(2, 5-difluorophenyl)-3-oxobutanoate VE009112View
Sitagliptin Methyl 4-(3, 4-difluorophenyl)-3-oxobutanoate VE009002View
Sitagliptin N, N'-(Ethane-1, 2-diyl)bis(3-amino-4-(2, 4, 5-trifluorophenyl)butanamide) Dihydrochloride VE008996View
Sitagliptin N-butanoyl Sitagliptin VE009114View
Sitagliptin Oxo Sitagliptin VE008998View
Sitagliptin Oxo-N-Boc Sitagliptin VE009003View
Sitagliptin Sitagliptin 1, 2, 4-Trifluorobenzene VE006177View CAS 367-23-7
Sitagliptin Sitagliptin 2 4 Difluorophenylaetic acid VL201004View CAS 81228-09-3
Sitagliptin Sitagliptin 2 5 difluoro phenyl acetic acid VL201003View CAS 85068-27-5
Sitagliptin Sitagliptin 2, 3, 6-Trifluorophenylacetic acid VE006178View CAS 114152-23-7
Sitagliptin Sitagliptin 2-Chloro Hydrazide Impurity VL201026View
Sitagliptin Sitagliptin 2-Desfluoro Impurity VE009000View CAS 486459-88-5
Sitagliptin Sitagliptin 3-4 Difluorophenyl Acetic Acid VL201002View CAS 658-93-5
Sitagliptin Sitagliptin Acid VE006432View CAS 936630-57-8
Sitagliptin Sitagliptin Acid Impurity VL201013View CAS 1204818-19-8
Sitagliptin Sitagliptin BOC Butanoic Acid VL201036View
Sitagliptin Sitagliptin Dimer Impurity VL201028View CAS 2072867-07-1
Sitagliptin Sitagliptin Dioxo Impurity VL201016View CAS 764667-64-3
Sitagliptin Sitagliptin Dioxo Impurity (Sodium Salt) VE006424View
Sitagliptin Sitagliptin EP Impurity A VE006598View CAS 823817-55-6
Sitagliptin Sitagliptin EP Impurity A (HCl salt) VL201001View
Sitagliptin Sitagliptin EP Impurity A (Phosphate Salt) VE006482View CAS (823817-58-9)
Sitagliptin Sitagliptin EP Impurity B VL201006View CAS 1345822-87-8
Sitagliptin Sitagliptin EP Impurity B (Phosphate Salt) VL201032View
Sitagliptin Sitagliptin EP Impurity C VL201005View CAS 1345822-86-7
Sitagliptin Sitagliptin EP Impurity C (Phosphate Salt) VL201031View
Sitagliptin Sitagliptin Enamine Impurity VL201014View CAS 767340-03-4
Sitagliptin Sitagliptin Fumarate Adduct VL201021View CAS 2088771-60-0
Sitagliptin Sitagliptin Hydroxy Amide Impurity VE008997View CAS 1253056-01-7
Sitagliptin Sitagliptin Imidazole Derivative VE008964View CAS 1364122-90-6
Sitagliptin Sitagliptin Impurity 1 VL201008View
Sitagliptin Sitagliptin Impurity 4 VL201011View CAS 486460-23-5
Sitagliptin Sitagliptin Impurity F (In House) VL201022View
Sitagliptin Sitagliptin Keto Amide Impurity VL201015View CAS 764667-65-4
Sitagliptin Sitagliptin N-Acetyl Impurity VE008598View CAS 1379666-94-0
Sitagliptin Sitagliptin N-Formyl Impurity VE006565View
Sitagliptin Sitagliptin Phenyl Crotonyl Analog VL201025View CAS 1253056-18-6
Sitagliptin Sitagliptin Pyrazinone Impurity VE009001View CAS 877402-45-4
Sitagliptin Sitagliptin Styrylacetyl Analog VL201024View CAS 1803026-58-5
Sitagliptin Sitagliptin Tartrate Hemihydrate VL201020View
Sitagliptin Sitagliptin Triazecine Analog VL201018View CAS 2088771-61-1
Sitagliptin Sitagliptin Triazole Impurity VL201012View
Sitagliptin Tert-Butyl 3-(Trifluoromethyl)-5, 6-dihydro-[1, 2, 4]triazolo[4, 3-a]pyrazine-7(8H)-carboxylate VE009004View CAS 877402-43-2
Sitagliptin Tert-Butyl 8-Oxo-3-(trifluoromethyl)-5, 6-dihydro-[1, 2, 4]triazolo[4, 3-a]pyrazine-7(8H)-carboxylate VE009006View CAS 877402-44-3
Sitagliptin 2, 3, 4-Trifluorophenylacetic Acid VE008129View CAS 243666-12-8
Sitagliptin 2, 3, 5-Trifluorophenylacetic Acid VE008130View CAS 132992-28-0
Sitagliptin 2, 4, 5-Trifluorobenzyl chloride VE006099View CAS 243139-71-1
Sitagliptin 2, 4, 6-Trifluorophenylacetic Acid VE008131View CAS 209991-63-9
Sitagliptin 2-desfluoro N-Boc methyl ester Impurity VE008999View
Sitagliptin 3-Hydroxy-3, 4-Dicaboxy-Butanamide-N-Hexanoic Acid VL201023View
Sitagliptin 5-(2-(2, 5-difluorophenyl)-1-hydroxyethylidene)-2, 2-dimethyl-1, 3-dioxane-4, 6-dione VE009007View CAS 764667-66-5
Sitagliptin 5-(Trifluoromethyl)-2-(chloromethyl)-1, 3, 4-oxadiazole VE0010888View CAS 723286-98-4
Sitagliptin (2Z)-1-[5, 6-Dihydro-3-(trifluoromethyl)-1, 2, 4-triazolo[4, 3-a]pyrazin-7(8H)-yl]-4-(2, 4, 5-trifluorophenyl)-2-buten-1-one VE008780View CAS 1803026-54-1
Sitagliptin (3R)-3-[(tert-Butoxycarbonyl)amino]-4-(2, 4-difluorophenyl)butanoic Acid VE009008View CAS 851307-12-5
Sitagliptin (E)-1-(3-(trifluoromethyl)-5, 6-dihydro-[1, 2, 4]triazolo[4, 3-a]pyrazin-7(8H)-yl)-4-(2, 4, 5-trifluorophenyl)but-2-en-1-one VE009354View
Sitagliptin (R)-Sitagliptin Methyl-Ester Impurity VL201034View CAS 881995-69-3
Sitagliptin (R)-Sitagliptin Methyl-Ester Impurity (HCl Salt) VE008550View CAS 1374985-05-3
Sitagliptin (R)-Sitagliptin N-Boc-Methyl-Ester Impurity VE006048View CAS 881995-73-9
Sitagliptin (S)-Sitagliptin N-Boc-Acid Impurity VL201030View CAS 922178-94-7
Sitagliptin (Z)-2, 2, 2-trifluoro-N'-(piperazin-2-ylidene)acetohydrazide VE0010889View CAS 763105-70-0

Sitagliptin Related Compound

Sitagliptin is a type of diabetic medication. Type 2 diabetes is a condition in which the body does not produce enough insulin or the insulin produced does not function correctly. This might result in elevated blood sugar levels (hyperglycaemia).


  • Kesavadev, Jothydev, et al. “Sitagliptin 100 Mg vs Glimepiride 1–3 Mg as an Add-on to Insulin and Metformin in Type 2 Diabetes (SWIM).” Endocrine Connections, vol. 6, no. 8, Nov. 2017, pp. 748–57,
  • Wikipedia Contributors. “Sitagliptin.” Wikipedia, Wikimedia Foundation, 2 Nov. 2022,
  • Sitagliptin and Metformin (Oral Route) Description and Brand Names – Mayo Clinic.”, 2023, metformin-oral-route/description/drug


What is the mechanisms of action of sitagliptin?

‌Sitagliptin acts by inhibiting the enzyme dipeptidyl peptidase 4 competitively (DPP-4). This enzyme degrades the gastrointestinal hormones GLP-1 and GIP, which are secreted in response to a meal.  By blocking the breakdown of GLP-1 and GIP, they are able to boost insulin production while suppressing glucagon release by pancreatic alpha cells.

In what combination is sitagliptin administered?

Metformin and sitagliptin are used together to treat type 2 diabetes-related elevated bloodsugar levels. Metformin inhibits sugar absorption from the stomach, decreases the release ofstored sugar from the liver, and improves your body’s use of sugar.

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(823817-58-9): Sitagliptin EP Impurity A (Phosphate Salt)

(823817-58-9): Sitagliptin EP Impurity A (Phosphate Salt)
Catalogue No.




Molecular Formula


Molecular Weight

505.31 g/mol

Parent drug



(S)-4-Oxo-4-[3-(trifluoromethyl)-5, 6-dihydro[1, 2, 4]triazolo[4, 3-a]pyrazin-7(8H)-yl]-1-(2, 4, 5-trifluorophenyl)butan-2-amine phosphate




Sitagliptin: A Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes By Shannon A Miller, Erin L St. Onge Container: Annals of Pharmacotherapy Year: 2006 Volume: 40 Issue: 7-8 DOI: 10.1345/aph.1g665 URL:




Sitagliptin EP Impurity A (Phosphate Salt)

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