Solifenacin Impurities

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Parent Drug Name Name of Impurity Catalogue No.
Solifenacin N-formyl-2-phenyl-1, 2, 3, 4-tetrahydroisoquinoline VE006246View CAS 80574-72-7
Solifenacin Phenethylbenzamide of Solifenacin VL131022View CAS 3278-14-6
Solifenacin Phenyl (S)-1-Phenyl-3, 4-Dihydroisoquinoline-2(1H)-Carboxylate VL131016View
Solifenacin Phenyltetrahydroisoquinolin VL131025View
Solifenacin S-(+)-3- Quinuclidinol VE0011024View CAS 34583-34-1
Solifenacin Solifenacin Benzoyl (S)-Quinuclidinyl Impurity VE007937View
Solifenacin Solifenacin EP Impurity A VL131001View CAS 118864-75-8
Solifenacin Solifenacin EP Impurity B VL131024View
Solifenacin Solifenacin EP Impurity C VL131007View CAS 1534326-81-2
Solifenacin Solifenacin EP Impurity D VL131008View CAS 2216750-52-4
Solifenacin Solifenacin EP Impurity E (HCl salt ) VL131010View CAS 42437-96-7
Solifenacin Solifenacin EP Impurity E (free base) VL131023View CAS 25333-42-0
Solifenacin Solifenacin EP Impurity F VL131004View CAS 774517-20-3
Solifenacin Solifenacin EP Impurity G VL131005View CAS 740780-79-4
Solifenacin Solifenacin EP Impurity G (Succinate Salt) VE006833View CAS 862207-70-3
Solifenacin Solifenacin EP Impurity H (HCl salt) VL131006View CAS 180468-38-6
Solifenacin Solifenacin EP Impurity I VL131002View CAS 180272-28-0
Solifenacin Solifenacin Hydroxyquinuclidine Impurity VL131027View CAS 34583-34-1
Solifenacin Solifenacin In house Impurity C VL131003View CAS 180468-42-2
Solifenacin Solifenacin Isomer Mixture VL131009View
Solifenacin Solifenacin Nitrophenyl Ester Impurity VL131011View CAS 1229227-22-8
Solifenacin Solifenacin Nitroso Impurity VE0010821View
Solifenacin Solifenacin Phenyl Tetrahydroisoquinoline Racemate VE005863View CAS 22990-19-8
Solifenacin Solifenacin Related Compound 19 VL131014View
Solifenacin 4, 6-Dimethyl-2-(methylthio)pyrimidine VE0010842View CAS 14001-64-0
Solifenacin (R)-1-Phenyl-1, 2, 3, 4-tetrahydroisoquinoline VE008433View CAS 180272-45-1

Solifenacin Related Compound

Solifenacin is categorized as an antimuscarinic (or anticholinergic) muscle relaxant. It works by relaxing the muscle present in the bladder’s wall. This helps to enhance the volume of urine your bladder can retain while also controlling pee discharge.


  • Chilman Blair, K., and J. L. Bosch. “Solifenacin: Treatment of Overactive Bladder.” Drugs of Today, vol. 40, no. 4, 2004, p. 343, Accessed 10 Mar. 2023.
  • Salih, Elsayed M., et al. “The Efficacy of Alpha-1A Blocker (Tamsulosin), Antimuscarinic (Solifenacin) and Their Combination in the Management of Double-J Stent-Related Lower Urinary Tract Symptoms: A Randomized Controlled Study.” African Journal of Urology, vol. 27, no. 1, Feb. 2021, Accessed 10 Mar. 2023.
  • Yang, Yu-Wan, et al. “Association between Different Anticholinergic Drugs and Subsequent Dementia Risk in Patients with Diabetes Mellitus.” PLOS ONE, edited by Gianluigi Forloni, vol. 12, no. 4, Apr. 2017, p. e0175335, Accessed 10 Mar. 2023. ‌


What is the mechanism of action of solifenacin?

Solifenacin serves to reduce bladder activity by blocking the smooth muscle wall surrounding the bladder from contracting. Micturition is generally triggered by acetylcholine muscarinic M3 receptor activation in the detrusor muscle wall.

Does solifenacin function as an alpha blocker?

Monotherapy with an alpha-1A blocker (tamsulosin) or an antimuscarinic (solifenacin) improves the DJ stent-related LUTS and QoL of patients who do not benefit from either treatment.

Is solifenacin succinate an anticholinergic?

In the treatment of (Overactive bladder)OAB, solifenacin is an anticholinergic medication that uses muscarinic acetylcholine receptors to minimize spasmolytic effects on bladder smooth muscle.

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118864-75-8: Solifenacin EP Impurity A

118864-75-8: Solifenacin EP Impurity A
Catalogue No.




Molecular Formula


Molecular Weight


Parent drug



(S)-1-Phenyl-1, 2, 3, 4-tetrahydroisoquinoline




Tantawy, Mahmoud A., et al. “Stability-Indicating HPTLC Method for the Simultaneous Detection and Quantification of Alfuzosin Hydrochloride, Solifenacin Succinate along with Four of Their Official Impurities.” Microchemical Journal, vol. 157, Sept. 2020, p. 104905, ?




Solifenacin EP Impurity A

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