Sulfamethoxazole Impurities

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Impurity structure Parent Drug Name Name of Impurity Catalogue No. CAS No.
Sulfamethoxazole CRS Sulfamethoxazole

Sulfamethoxazole CRS

PVE0013 723-46-6
Sulfamethoxazole EP Impurity A Sulfamethoxazole

Sulfamethoxazole EP Impurity A

VL1990005 21312-10-7
Sulfamethoxazole EP Impurity A-D4 Sulfamethoxazole

Sulfamethoxazole EP Impurity A-D4

DVE001445 1215530-54-3
Sulfamethoxazole EP Impurity B Sulfamethoxazole

Sulfamethoxazole EP Impurity B

VL1990006 135529-16-7
Sulfamethoxazole EP Impurity C Sulfamethoxazole

Sulfamethoxazole EP Impurity C

VL1990003 1072-67-9
Sulfamethoxazole EP Impurity D Sulfamethoxazole

Sulfamethoxazole EP Impurity D

VL1990001 121-57-3
Sulfamethoxazole EP Impurity E Sulfamethoxazole

Sulfamethoxazole EP Impurity E

VL1990002 63-74-1
Sulfamethoxazole EP Impurity F Sulfamethoxazole

Sulfamethoxazole EP Impurity F

VL1990004 17103-52-5
Sulfamethoxazole Impurity 2 Sulfamethoxazole

Sulfamethoxazole Impurity 2

VE0019758 51821-47-7
Sulfamethoxazole N4-Glucoside Sulfamethoxazole

Sulfamethoxazole N4-Glucoside

VE0014289 119691-75-7
Sulfamethoxazole-D4 Sulfamethoxazole

Sulfamethoxazole-D4

DVE001446 1020719-86-1

Sulfamethoxazole Related Compound

Sulfamethoxazole is an oral sulfonamide antibiotic used to treat infections of the urinary tract, respiratory system, and gastrointestinal tract when combined with trimethoprim.

References

  • ‌“Sulfamethoxazole: Uses, Interactions, Mechanism of Action | DrugBank Online.” Drugbank.com, DrugBank, 2015, go.drugbank.com/drugs/DB01015. Accessed 1 Feb. 2023.
  • ‌Masters, Philip A., et al. “Trimethoprim-Sulfamethoxazole Revisited.” Archives of Internal Medicine, vol. 163, no. 4, Feb. 2003, p. 402, https://doi.org/10.1001/archinte.163.4.402. Accessed 1 Feb. 2023.
  • Lundstrom TS;Sobel JD. “Vancomycin, Trimethoprim-Sulfamethoxazole, and Rifampin.” Infectious Disease Clinics of North America, vol. 9, no. 3, Infect Dis Clin North Am, 2023, pubmed.ncbi.nlm.nih.gov/7490442/. Accessed 1 Feb. 2023.

FAQ’s

Sulfamethoxazole belongs to what drug class?

Sulfamethoxazole is a bacteriostatic sulfonamide antibiotic that inhibits the production of folic acid in sensitive bacteria.

What is the mechanism of sulfamethoxazole?

Trimethoprim and sulfamethoxazole block bacterial production of tetrahydrofolic acid, a physiologically active form of folic acid that is required for the synthesis of thymidine, purines, and bacterial DNA.

What bacteria does sulfamethoxazole target?

Trimethoprim-sulfamethoxazole, a broad-spectrum synergistic combination, is still widely used to treat gram-negative bacterial infections, particularly those in the urinary tract. It has shown tremendous success in the prevention and treatment of Pneumocystis carinii pneumonia.