Sulfaquinoxaline is a long acting sulfonamide veterinary medicine used to treat coccidiosis in cattle and sheep; it is a bacteriostatic and anticoccidial agent that interferes with folic acid synthesis in susceptible protozoa and bacteria by competitive inhibition of dihydropteroate synthase. In practice it is supplied as technical powder or oral granules and formulated into drinking-water premixes or drenches for group or individual dosing; it has limited aqueous solubility, moderate oral bioavailability in ruminants, and demonstrates greater persistence in tissues than short acting sulfonamides, so handling, stability under dry storage and control of light and alkaline exposure are important in manufacture and storage.
Parent: Sulfaquinoxaline
Technical-grade Sulfaquinoxaline is controlled for related substances arising from synthesis and degradation such as N4-acetyl-sulfaquinoxaline, hydroxy and desulfonyl derivatives, ring-opened aniline-type impurities and residual solvents; typical quality control specifications for raw material grade commonly require assay of active substance at 98.0 percent or greater and set limits for related compounds with individual impurities not greater than 0.5 percent and total of all related substances not exceeding 1.5 percent, with additional limits for specified known genotoxic or reactive impurities and solvent residues as defined in the supplier specification.
Sulfaquinoxaline is used primarily to treat and control coccidiosis in cattle and sheep and may also show activity as a sulfonamide antibacterial; use should follow licensed indications, veterinary guidance and local residue regulations.
It acts by inhibiting dihydropteroate synthase, reducing folate synthesis required for nucleic acid production in protozoa and susceptible bacteria, producing a bacteriostatic and anticoccidial effect.
Typical QC limits for technical material specify assay greater than or equal to 98.0 percent and related substances monitored by chromatographic methods with individual unspecified impurities generally limited to 0.5 percent and total impurities limited to about 1.5 percent, plus specified limits for known named impurities and residual solvents per supplier monograph.
Yes, because Sulfaquinoxaline is relatively persistent, withdrawal periods for meat and milk must be observed according to the product label and local regulatory guidance and residue monitoring should follow validated analytical methods.
