Sumatriptan Impurities

Sumatriptan is prescribed to adults to treat acute migraine headaches.

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Sumatriptan Related Compound

It is not used to treat or prevent migraine headaches or cluster headaches. Sumatriptan acts in the brain to alleviate migraine headache discomfort. It belongs to the triptan class of medications.


  • “Sumatriptan: MedlinePlus Drug Information.”, 2015,,and%20other%20symptoms%20of%20migraine. Accessed 10 Mar. 2023.
  • Sullivan, John T., et al. “Psychoactivity and Abuse Potential of Sumatriptan.” Clinical Pharmacology and Therapeutics, vol. 52, no. 6, Dec. 1992, pp. 635–42, Accessed 10 Mar. 2023.
  • Deen, Marie, et al. “Association between Sumatriptan Treatment during a Migraine Attack and Central 5-HT1B Receptor Binding.” JAMA Neurology, vol. 76, no. 7, July 2019, p. 834, Accessed 10 Mar. 2023.


What drug category does sumatriptan belong to?

Sumatriptan is part of a class of drugs known as selective serotonin receptor agonists. It works by constricting blood vessels in the head, preventing pain signals from reaching the brain, and preventing the production of certain natural compounds that produce pain, nausea, and other migraine symptoms.

Is sumatriptan a psychoactive drug?

Sumatriptan was psychoactive, distinguished from placebo, resulted in a dose-related decrease in euphoria, increased scores on measures of apathetic sedation and dislike, and lacked identification as a prototypic drug of abuse.

Does sumatriptan increase serotonin?

A sustained rise in endogenous serotonin even after sumatriptan treatment might explain the significantly high occupancies in the two patients who still had migraine during the postictal scan.