| Parent Drug Name | Name of Impurity | Catalogue No. | |
|---|---|---|---|
| Ascomycin | Ascomycin 19-Epimer | VE007260 | View |
| Tacrolimus | Desmethyl Tacrolimus | VE007975 | View CAS 132172-14-6 |
| Tacrolimus | Tacrolimus 19-epimer | VE006878 | View CAS 144490-63-1 |
| Tacrolimus | Tacrolimus 21-Carboxylic acid Impurity | VE006641 | View |
| Tacrolimus | Tacrolimus 8-Propyl Analog | VE006442 | View CAS 104987-30-6 |
| Tacrolimus | Tacrolimus C4-epimer Diene | VE0010162 | View CAS 93848-81-8 |
| Tacrolimus | Tacrolimus Dehydro Impurity | VE0011640 | View CAS 129212-37-9 |
| Tacrolimus | Tacrolimus Diene Impurity | VE009734 | View CAS 104987-16-8 |
| Tacrolimus | Tacrolimus EP Impurity B | VE009199 | View |
| Tacrolimus | Tacrolimus EP Impurity C | VE009816 | View |
| Tacrolimus | Tacrolimus EP Impurity D | VE006441 | View CAS 129212-35-7 |
| Tacrolimus | Tacrolimus EP Impurity H | VE0010577 | View CAS 143210-33-7 |
| Tacrolimus | Tacrolimus Hydroxy Acid Impurity | VE000122 | View CAS 1700657-83-5 |
| Tacrolimus | Tacrolimus Lactone Isomer | VE0010698 | View CAS 134590-88-8 |
| Tacrolimus | Tacrolimus Methyl Acryl Aldehyde | VE0011642 | View CAS 109466-74-2 |
| Tacrolimus | Tacrolimus Open Ring Impurity | VL3770002 | View CAS 1393890-33-9 |
| Tacrolimus | Tacrolimus Regioisomer | VE007286 | View |
| Tacrolimus | Tacrolimus Related Compound A | VL3770001 | View CAS 104987-12-4 |
| Tacrolimus | 13-O-Desmethyl Tacrolimus | VE0012233 | View CAS 139958-51-3 |
| Tacrolimus | 9-Norketo FK-506 | VE0011639 | View CAS 123719-19-7 |
Tacrolimus Related Compound
Atopic dermatitis is a skin disorder characterised by itching, redness, and inflammation, similar to an allergic reaction.
References
- “Tacrolimus Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing – WebMD.” Webmd.com, 2023, www.webmd.com/drugs/2/drug-10097-6108/tacrolimus-oral/tacrolimus-oral/details#:~:text=Tacrolimus%20is%20used%20with%20other,if%20it%20were%20your%20own. Accessed 2 Mar. 2023.
- Junna, M. R., and A. A. Rabinstein. “Tacrolimus Induced Leukoencephalopathy Presenting with Status Epilepticus and Prolonged Coma.” Journal of Neurology, Neurosurgery & Psychiatry, vol. 78, no. 12, Dec. 2007, pp. 1410–11, https://doi.org/10.1136/jnnp.2007.121806. Accessed 2 Mar. 2023.
- Yu, Yifeng, et al. “Tacrolimus Downregulates Inflammation by Regulating Pro-/Anti-Inflammatory Responses in LPS-Induced Keratitis.” Molecular Medicine Reports, vol. 16, no. 5, May 2017, pp. 5855–62, https://doi.org/10.3892/mmr.2017.7353. Accessed 2 Mar. 2023.
FAQ
What class of drug is tacrolimus?
Tacrolimus is used in combination with other drugs to avoid transplant rejection of a kidney, heart, liver, or lung. This medicine belongs to the immunosuppressant family of medications. It works by suppressing your immune system to let your body accept the new organ as if it were your own.
What is the mechanism of action of tacrolimus?
Tacrolimus inhibits NF-AT dephosphorylation. In summary, tacrolimus inhibits peptidylprolyl isomerase activity by forming a novel complex with the immunophilin FKBP12 (FK506 binding protein).
Is tacrolimus anti-inflammatory?
Our earlier research found that tacrolimus had a clear anti-inflammatory impact by not only lowering inflammatory cell infiltration but also inhibiting the release of pro-inflammatory cytokines in innate immune responses at an early stage of corneal fungal infection.
