Terbinafine Impurities and Related Compound

Structure

Product Name

CAS No.

Cat No.

Action

N-Demethylterbinafine (HCl Salt)

Parent: Terbinafine

CAS No.: 152830-98-3

Cat No.: VE0022318

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N-Desmethyl Terbinafine

Parent: Terbinafine

CAS No.: 99473-11-7

Cat No.: VE0019089

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N-Methyl-1-(naphthalen-1-yl)-N-(naphthalen-1-ylmethyl)methanamine (Hydrochloride)

Parent: Terbinafine

CAS No.: 99802-54-7

Cat No.: VE0021258

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N-Nitroso N-desmethyl Terbinafine D7

Parent: Terbinafine

CAS No.: N/A

Cat No.: DVE002029

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N-Nitroso Terbinafine Degradant

Parent: Terbinafine/ N-Nitroso

CAS No.: N/A

Cat No.: VE0020254

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N-Nitroso Terbinafine EP Impurity A

Parent: N-Nitroso/ Terbinafine

CAS No.: 296760-88-8

Cat No.: VE0020918

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N-Nitroso-N-desmethyl Terbinafine

Parent: Terbinafine

CAS No.: 3121215-20-8

Cat No.: VE0020317

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Terbinafine EP Impurity A

Parent: Terbinafine

CAS No.: 14489-75-9

Cat No.: VL930004

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Terbinafine EP Impurity A (HCl Salt)

Parent: Terbinafine

CAS No.: 65473-13-4

Cat No.: VE0012281

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Terbinafine EP Impurity B

Parent: Terbinafine

CAS No.: 78628-81-6

Cat No.: VL930002

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Terbinafine EP Impurity C

Parent: Terbinafine

CAS No.: 877265-30-0

Cat No.: VL930005

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Terbinafine EP Impurity C (Free Base)

Parent: Terbinafine

CAS No.: 187540-01-8

Cat No.: VE006648

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Terbinafine EP Impurity D (HCl salt)

Parent: Terbinafine

CAS No.: 877265-33-3

Cat No.: VL930006

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Terbinafine EP Impurity D(free base)

Parent: Terbinafine

CAS No.: 151222-50-3

Cat No.: VL930009

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Terbinafine EP Impurity E

Parent: Terbinafine

CAS No.: N/A

Cat No.: VL930001

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Terbinafine EP Impurity E

Parent: Terbinafine

CAS No.: N/A

Cat No.: VE0019087

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Terbinafine EP Impurity E (Free Base)

Parent: Terbinafine

CAS No.: 934365-23-8

Cat No.: VE006722

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Terbinafine EP Impurity F

Parent: Terbinafine

CAS No.: 926281-74-5

Cat No.: VL930008

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Terbinafine EP Impurity F(HCl Salt)

Parent: Terbinafine

CAS No.: N/A

Cat No.: VE0021257

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Terbinafine for system suitability CRS (Y0001143)

Parent: Terbinafine

CAS No.: 78628-80-5

Cat No.: PVE00420

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Terbinafine Hydrochloride Working Standard (Secondary Reference Standard)

Parent: Terbinafine/ Terbinafine Hydrochloride

CAS No.: 78628-80-5

Cat No.: VE0026940

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Terbinafine Impurity 1

Parent: Terbinafine

CAS No.: 2579-21-7

Cat No.: VE0013093

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Terbinafine Impurity 12

Parent: Terbinafine

CAS No.: 138139-82-9

Cat No.: VE0019078

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Terbinafine Impurity 15

Parent: Terbinafine

CAS No.: 173200-56-1

Cat No.: VE0019077

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Terbinafine Impurity 2

Parent: Terbinafine

CAS No.: 704909-67-1

Cat No.: VE009882

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Terbinafine Impurity 2 (HCl Salt)

Parent: Terbinafine

CAS No.: N/A

Cat No.: VE0019091

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Terbinafine Impurity 3

Parent: Terbinafine

CAS No.: N/A

Cat No.: VE0019090

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Terbinafine Impurity 8

Parent: Terbinafine

CAS No.: N/A

Cat No.: VE0019088

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Terbinafine N-Oxide

Parent: Terbinafine

CAS No.: N/A

Cat No.: VE0019080

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Terbinafine Process Impurity

Parent: Terbinafine

CAS No.: 635708-74-6

Cat No.: VL930007

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Terbinafine-D7 (HCl Salt)

Parent: Terbinafine

CAS No.: N/A

Cat No.: DVE001273

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1-Chloro-6,6-Dimethylhept-2-en-4-yne

Parent: Terbinafine

CAS No.: 287471-30-1

Cat No.: VE0010691

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Types of Impurities in Terbinafine

Process-Related Impurities

Unreacted intermediates from chemical synthesis

Residual solvents (e.g., methanol, isopropanol, acetone)

By-products from catalytic reactions

Degradation Impurities

Oxidative degradation (formation of hydroxylated derivatives)

Hydrolytic degradation (due to moisture exposure)

Photodegradation (structural breakdown upon light exposure)

Elemental Impurities

Heavy metals (lead, arsenic, mercury, cadmium)

Residual catalysts (e.g., palladium, platinum from hydrogenation reactions)

Analytical Techniques for Impurity Detection

High-Performance Liquid Chromatography (HPLC)

Gas Chromatography (GC)

Fourier-Transform Infrared Spectroscopy (FT-IR)

Mass Spectrometry (MS)

FAQ

Terbinafine Impurities

N-Demethylterbinafine (HCl Salt)

N-Desmethyl Terbinafine

N-Methyl-1-(naphthalen-1-yl)-N-(naphthalen-1-ylmethyl)methanamine (Hydrochloride)

N-Nitroso N-desmethyl Terbinafine D7

N-Nitroso Terbinafine Degradant

N-Nitroso Terbinafine EP Impurity A

N-Nitroso-N-desmethyl Terbinafine

Terbinafine EP Impurity A

Terbinafine EP Impurity A (HCl Salt)

Terbinafine EP Impurity B

Terbinafine EP Impurity C

Terbinafine EP Impurity C (Free Base)

Terbinafine EP Impurity D (HCl salt)

Terbinafine EP Impurity D(free base)

Terbinafine EP Impurity E

Terbinafine EP Impurity E

Terbinafine EP Impurity E (Free Base)

Terbinafine EP Impurity F

Terbinafine EP Impurity F(HCl Salt)

Terbinafine for system suitability CRS (Y0001143)

Terbinafine Hydrochloride Working Standard (Secondary Reference Standard)

Terbinafine Impurity 1

Terbinafine Impurity 12

Terbinafine Impurity 15

Terbinafine Impurity 2

Terbinafine Impurity 2 (HCl Salt)

Terbinafine Impurity 3

Terbinafine Impurity 8

Terbinafine N-Oxide

Terbinafine Process Impurity

Terbinafine-D7 (HCl Salt)

1-Chloro-6,6-Dimethylhept-2-en-4-yne

Terbinafine Related Compound

Types of Impurities in Terbinafine

FAQ

Is terbinafine a strong antifungal?

What class of drug is terbinafine?

What does terbinafine do to the body?

Is terbinafine a high-risk medication?