Tiagabine Impurities

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Parent Drug Name Name of Impurity Catalogue No.
Tiagabine Tiagabine Impurity 1 VL141001View CAS 157925-28-5
Tiagabine Tiagabine Impurity 2 VL141002View CAS 161014-55-7
Tiagabine Tiagabine Impurity III VL141004View CAS 30717-55-6
Tiagabine Tiagabine Keto Impurity VL141005View CAS 161014-56-8
Tiagabine Tiagabine N Oxide VL141003View

Tiagabine Related Compound

Tiagabine is used to treat partial seizures (a type of epilepsy). Tiagabine belongs to the anticonvulsant drug class. It raises the concentration of natural substances in the brain that inhibit seizure activity.

References

  • Meldrum, Brian S., and Astrid G. Chapman. “Basic Mechanisms of Gabitril (Tiagabine) and Future Potential Developments.” Epilepsia, vol. 40, no. s9, Sept. 1999, pp. S2–6, https://doi.org/10.1111/j.1528-1157.1999.tb02087.x. Accessed 8 Mar. 2023.
  • Novak, Vera, et al. “Treatment of Painful Sensory Neuropathy with Tiagabine: A Pilot Study.” Clinical Autonomic Research, vol. 11, no. 6, Dec. 2001, pp. 357–61, https://doi.org/10.1007/bf02292767. Accessed 8 Mar. 2023.
  • Kast, R. E. “Tiagabine May Reduce Bruxism and Associated Temporomandibular Joint Pain.” Anesthesia Progress, vol. 52, no. 3, Sept. 2005, pp. 102–4, https://doi.org/10.2344/0003-3006(2005)52[102:tmrbaa]2.0.co;2. Accessed 8 Mar. 2023. ‌

FAQ

What is the mechanism of action of tiagabine?

Tiagabine is a highly specific inhibitor of the gamma-aminobutyric acid (GABA) transporter (GAT-1) in the cortex and hippocampus. It prolongs inhibitory postsynaptic potentials by delaying the absorption of synaptically produced GABA.

Does tiagabine treat nerve pain?

Tiagabine may offer prospective advantages for the treatment of painful neuropathy; nevertheless, its efficacy must be evaluated in a broader study.

Does tiagabine reduce bruxism?

Tiagabine also be very successful at reducing nocturnal bruxism, trismus, and the resulting morning discomfort in the jaw, temporomandibular joint, masticatory muscles, and teeth. This is suggested by four of the five cases that were presented here.

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157925-28-5: Tiagabine Impurity 1

157925-28-5: Tiagabine Impurity 1
Catalogue No.

VL141001

CAS No.

157925-28-5

Molecular Formula

C₂₀H₂₇NO₄S₂

Molecular Weight

409.56

Parent drug

Tiagabine

IUPAC Name

(R)-1-[4, 4-Bis(3-methyl-2-thienyl)-3, 4-dihydroxybutyl]-3-piperidinecarboxylic Acid

Synonyms

N/A

References

Sci-Hub, The Efficacy and Tolerability of Tiagabine in Adult Patients With Post-Traumatic Stress Disorder, 10.1097/jcp.0b013e31802e5115. (2022). Retrieved January 27, 2022, from Sci-hub.ee website: https://sci-hub.ee/10.1097/jcp.0b013e31802e5115

Status

In-stock

ListName

Tiagabine Impurity 1

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