Tiagabine Impurities

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Impurity structure Parent Drug Name Name of Impurity Catalogue No. CAS No.
Tiagabine Impurity 1 Tiagabine

Tiagabine Impurity 1

VL141001 157925-28-5
Tiagabine Impurity 2 Tiagabine

Tiagabine Impurity 2

VL141002 161014-55-7
Tiagabine Impurity III Tiagabine

Tiagabine Impurity III

VL141004 30717-55-6
Tiagabine Keto Impurity Tiagabine

Tiagabine Keto Impurity

VL141005 161014-56-8
Tiagabine N Oxide Tiagabine

Tiagabine N Oxide

VL141003 N/A
Tiagabine-D6 (HCl Salt) Tiagabine

Tiagabine-D6 (HCl Salt)

DVE001381 1217808-68-8

Tiagabine Related Compound

Tiagabine is used to treat partial seizures (a type of epilepsy). Tiagabine belongs to the anticonvulsant drug class. It raises the concentration of natural substances in the brain that inhibit seizure activity.

References

  • Meldrum, Brian S., and Astrid G. Chapman. “Basic Mechanisms of Gabitril (Tiagabine) and Future Potential Developments.” Epilepsia, vol. 40, no. s9, Sept. 1999, pp. S2–6, https://doi.org/10.1111/j.1528-1157.1999.tb02087.x. Accessed 8 Mar. 2023.
  • Novak, Vera, et al. “Treatment of Painful Sensory Neuropathy with Tiagabine: A Pilot Study.” Clinical Autonomic Research, vol. 11, no. 6, Dec. 2001, pp. 357–61, https://doi.org/10.1007/bf02292767. Accessed 8 Mar. 2023.
  • Kast, R. E. “Tiagabine May Reduce Bruxism and Associated Temporomandibular Joint Pain.” Anesthesia Progress, vol. 52, no. 3, Sept. 2005, pp. 102–4, https://doi.org/10.2344/0003-3006(2005)52[102:tmrbaa]2.0.co;2. Accessed 8 Mar. 2023. ‌

FAQ

What is the mechanism of action of tiagabine?

Tiagabine is a highly specific inhibitor of the gamma-aminobutyric acid (GABA) transporter (GAT-1) in the cortex and hippocampus. It prolongs inhibitory postsynaptic potentials by delaying the absorption of synaptically produced GABA.

Does tiagabine treat nerve pain?

Tiagabine may offer prospective advantages for the treatment of painful neuropathy; nevertheless, its efficacy must be evaluated in a broader study.

Does tiagabine reduce bruxism?

Tiagabine also be very successful at reducing nocturnal bruxism, trismus, and the resulting morning discomfort in the jaw, temporomandibular joint, masticatory muscles, and teeth. This is suggested by four of the five cases that were presented here.