Ticagrelor Impurities

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Impurity structure Parent Drug Name Name of Impurity Catalogue No. CAS No.
ent-Ticagrelor Ticagrelor

ent-Ticagrelor

VE009338 2096989-55-6
Ethyl 2-(((3aS,4R,6S,6aR)-6-(2-ethoxy-2-oxoethoxy)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)amino)acetate Ticagrelor

Ethyl 2-(((3aS,4R,6S,6aR)-6-(2-ethoxy-2-oxoethoxy)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)amino)acetate

VE0010914 N/A
Ethyl 2-(((3aS,4R,6S,6aR)-6-amino-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)acetate oxalate Ticagrelor

Ethyl 2-(((3aS,4R,6S,6aR)-6-amino-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)acetate oxalate

VE0010916 N/A
Ethyl 2-(((3aS,4R,6S,6aR)-6-hydroxy-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)amino)acetate Ticagrelor

Ethyl 2-(((3aS,4R,6S,6aR)-6-hydroxy-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)amino)acetate

VE0010915 N/A
N-((1R,2S,3S,4S)-2,3-dihydroxy-4-(2-hydroxy ethoxy)cyclopentyl)-N-(3-((1R,2S,3S,4S)-2,3-dihydroxy-4-(2-hydroxyethoxy) cyclopentyl)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)nitrous amide Ticagrelor

N-((1R,2S,3S,4S)-2,3-dihydroxy-4-(2-hydroxy ethoxy)cyclopentyl)-N-(3-((1R,2S,3S,4S)-2,3-dihydroxy-4-(2-hydroxyethoxy) cyclopentyl)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)nitrous amide

VE0013357 N/A
N-(2-(3,4-difluorophenyl)cyclo propyl)-N-(5-(propylthio)-3-((1R,2S,3S,4R)-2,3,4-trihydroxy cyclopentyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)nitrous amide Ticagrelor

N-(2-(3,4-difluorophenyl)cyclo propyl)-N-(5-(propylthio)-3-((1R,2S,3S,4R)-2,3,4-trihydroxy cyclopentyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7-yl)nitrous amide

VE0013360 N/A
N-(3-((1R,2S)-2-(3,4-difluoro phenyl)cyclopropyl)-5-(propylthio)-3H-[1,2,3]triazolo [4,5-d]pyrimidin-7-yl)-N-((1R,2S, 3S,4S)-2,3-dihydroxy -4-(2-hydroxy ethoxy) cyclopentyl)nitrous amide Ticagrelor

N-(3-((1R,2S)-2-(3,4-difluoro phenyl)cyclopropyl)-5-(propylthio)-3H-[1,2,3]triazolo [4,5-d]pyrimidin-7-yl)-N-((1R,2S, 3S,4S)-2,3-dihydroxy -4-(2-hydroxy ethoxy) cyclopentyl)nitrous amide

VE0013358 N/A
N-(5-amino-6-chloro-2-(propylsulfinyl)pyrimidin-4-yl)-N-((1R,2S,3S,4S)-2,3-dihydroxy-4-(2-hydroxyethoxy)cyclopentyl)nitrous amide Ticagrelor

N-(5-amino-6-chloro-2-(propylsulfinyl)pyrimidin-4-yl)-N-((1R,2S,3S,4S)-2,3-dihydroxy-4-(2-hydroxyethoxy)cyclopentyl)nitrous amide

VE0013356 N/A
N-(5-amino-6-chloro-2-(propylthio)pyrimidin-4-yl)-N-((1R,2S,3S,4S)-2,3-dihydroxy-4-(2-hydroxyethoxy)cyclopentyl)nitrous amide Ticagrelor

N-(5-amino-6-chloro-2-(propylthio)pyrimidin-4-yl)-N-((1R,2S,3S,4S)-2,3-dihydroxy-4-(2-hydroxyethoxy)cyclopentyl)nitrous amide

VE0013354 N/A
N-(5-amino-6-chloro-2-(propylthio)pyrimidin-4-yl)-N-((3aS,4R,6S,6aR)-6-(2-hydroxyethoxy)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)nitrous amide Ticagrelor

N-(5-amino-6-chloro-2-(propylthio)pyrimidin-4-yl)-N-((3aS,4R,6S,6aR)-6-(2-hydroxyethoxy)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)nitrous amide

VE0013355 N/A
N-Nitroso Ticagrelor Ticagrelor

N-Nitroso Ticagrelor

VE008489 2476859-55-7
S-Propyl-2-thiobarbituric Acid Ticagrelor

S-Propyl-2-thiobarbituric Acid

VE0010911 145783-12-6
Tert-butyl 2-(((3aS,4R,6S,6aR)-6-amino-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)acetate Ticagrelor

Tert-butyl 2-(((3aS,4R,6S,6aR)-6-amino-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)acetate

VE0010919 N/A
Ticagrelor Amine Impurity Ticagrelor

Ticagrelor Amine Impurity

VL3180008 1902184-02-4
Ticagrelor DP3 Ticagrelor

Ticagrelor DP3

VE006279 1251765-07-7
Ticagrelor EP Impurity C Ticagrelor

Ticagrelor EP Impurity C

VL3180018 1616703-93-5
Ticagrelor EP Impurity G Ticagrelor

Ticagrelor EP Impurity G

VL3180006 N/A
Ticagrelor EP Impurity H Ticagrelor

Ticagrelor EP Impurity H

VL3180004 N/A
Ticagrelor Impurity 15 Ticagrelor

Ticagrelor Impurity 15

VE007040 N/A
Ticagrelor Impurity 23 Ticagrelor

Ticagrelor Impurity 23

VE007033 1345413-20-8
Ticagrelor Impurity 4 Ticagrelor

Ticagrelor Impurity 4

VE0020321 2248538-63-6
Ticagrelor Impurity 62 (HCl Salt) Ticagrelor

Ticagrelor Impurity 62 (HCl Salt)

VE0016120 N/A
Ticagrelor Impurity 70 Ticagrelor

Ticagrelor Impurity 70

VE007039 1808068-84-9
Ticagrelor Impurity 76 Ticagrelor

Ticagrelor Impurity 76

VE0017559 274693-49-1
Ticagrelor Impurity 81 Ticagrelor

Ticagrelor Impurity 81

VE0011566 1006376-62-0
Ticagrelor Impurity 83 Ticagrelor

Ticagrelor Impurity 83

VE0014214 274693-39-9
Ticagrelor Impurity N Ticagrelor

Ticagrelor Impurity N

VE0018273 1643378-47-5
Ticagrelor IP Impurity D Ticagrelor

Ticagrelor IP Impurity D

VL3180005 N/A
Ticagrelor IP Impurity H Ticagrelor

Ticagrelor IP Impurity H

VL3180007 N/A
Ticagrelor Nitroso Impurity 19 Ticagrelor

Ticagrelor Nitroso Impurity 19

VE0016122 N/A
Ticagrelor Nitroso Impurity 2 Ticagrelor

Ticagrelor Nitroso Impurity 2

VE0015280 N/A
Ticagrelor Pyrimidine Dimer Ticagrelor

Ticagrelor Pyrimidine Dimer

VL3180013 2205903-73-5
Ticagrelor Related Compound -01 Ticagrelor

Ticagrelor Related Compound -01

VL3180015 155899-66-4
Ticagrelor Related Compound 101 Ticagrelor

Ticagrelor Related Compound 101

VE0011560 2376278-69-0
Ticagrelor Related Compound 17 Ticagrelor

Ticagrelor Related Compound 17

VE0018251 376608-74-1
Ticagrelor Related Compound 27 (Oxalate Salt) Ticagrelor

Ticagrelor Related Compound 27 (Oxalate Salt)

VE0011557 1816939-47-5
Ticagrelor Related Compound 28 Ticagrelor

Ticagrelor Related Compound 28

VE007035 220352-36-3
Ticagrelor Related Compound 31 (HCl Salt) Ticagrelor

Ticagrelor Related Compound 31 (HCl Salt)

VE0014216 1402222-66-5
Ticagrelor Related Compound 47 Ticagrelor

Ticagrelor Related Compound 47

VE0017955 1445580-43-7
Ticagrelor Related Compound 76 Ticagrelor

Ticagrelor Related Compound 76

VL3180016 N/A
Ticagrelor Related Compound 91 Ticagrelor

Ticagrelor Related Compound 91

VE0011555 2376278-68-9
Ticagrelor Related Compound 94 Ticagrelor

Ticagrelor Related Compound 94

VE007034 1427524-53-5
Ticagrelor Related Compound A Ticagrelor

Ticagrelor Related Compound A

VE006280 220352-38-5
Ticagrelor related compound B Ticagrelor

Ticagrelor related compound B

VL3180019 1788033-05-5
Ticagrelor sulfoxide (Mixture of Diastereomers) Ticagrelor

Ticagrelor sulfoxide (Mixture of Diastereomers)

VL3180011 1644461-85-7
Ticagrelor Sulphonate Impurity Ticagrelor

Ticagrelor Sulphonate Impurity

VE0020385 N/A
Ticagrelor Triazole Isomer Ticagrelor

Ticagrelor Triazole Isomer

VL3180014 N/A
Ticagrelor Triol Impurity Ticagrelor

Ticagrelor Triol Impurity

VL3180001 220347-05-7
Ticagrelor-D7 Ticagrelor

Ticagrelor-D7

DVE001228 1265911-55-4
(1R,2R)-2-(3,4-Difluorophenyl)-cyclopropanamine Ticagrelor

(1R,2R)-2-(3,4-Difluorophenyl)-cyclopropanamine

VE0011565 1414348-35-8

Ticagrelor Related Compound

Ticagrelor is a kind of antiplatelet medication. It improves the flow of blood via your veins. This implies that your blood is less prone to form a hazardous blood clot. If you have an elevated risk of blood clots, using ticagrelor can help avoid them.

References

FAQ

What is the mechanism of action of ticagrelor?

Ticagrelor is a P2Y12-receptor antagonist that is used orally. In vitro investigations have shown that ticagrelor binds to the P2Y12 receptor reversibly and noncompetitively at a location different from that of the endogenous agonist adenosine diphosphate (ADP).

Why is ticagrelor taken with aspirin?

Ticagrelor in combination with aspirin decreased the rates of the composite endpoint of cardiovascular mortality, myocardial infarction (MI), and stroke more efficiently than clopidogrel in combination with aspirin among patients with acute coronary syndromes (ACS) in the PLATO study.

What is the indication for ticagrelor?

Ticagrelor is prescribed to patients with the acute coronary syndrome (ACS) or a history of myocardial infarction to lower the risk of cardiovascular mortality, myocardial infarction, and stroke (MI).