Tofacitinib Impurities

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Impurity structure Parent Drug Name Name of Impurity Catalogue No. CAS No.
Butyl 4-cyano-3-imino-5-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-5-oxopentanoate Tofacitinib

Butyl 4-cyano-3-imino-5-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-5-oxopentanoate

VE0010254 N/A
Dihydro Tofacitinib Citrate Impurity Tofacitinib

Dihydro Tofacitinib Citrate Impurity

VE008139 N/A
Dihydro Tofacitinib Impurity Tofacitinib

Dihydro Tofacitinib Impurity

VE008429 1640972-35-5
Ethyl 4-cyano-3-imino-5-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-5-oxopentanoate Tofacitinib

Ethyl 4-cyano-3-imino-5-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-5-oxopentanoate

VE0010253 2102039-99-4
N-(1-(2-cyanoacetyl)-4-methylpiperidin-3-yl)-N-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)nitrous amide Tofacitinib

N-(1-(2-cyanoacetyl)-4-methylpiperidin-3-yl)-N-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)nitrous amide

VE009892 N/A
N-(1-benzyl-4-methylpiperidin-3-yl)-N-methylnitrous amide Tofacitinib

N-(1-benzyl-4-methylpiperidin-3-yl)-N-methylnitrous amide

VE0011029 N/A
N-Desmethyl Tofacitinib Tofacitinib

N-Desmethyl Tofacitinib

VE0020324 1527525-58-1
N-methyl-N-((3S,4S)-4-methyl-1-nitrosopiperidin-3-yl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-amine Tofacitinib

N-methyl-N-((3S,4S)-4-methyl-1-nitrosopiperidin-3-yl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-amine

VE0011034 N/A
N-methyl-N-((3S,4S)-4-methyl-1-nitrosopiperidin-3-yl)-7-nitroso-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-amine Tofacitinib

N-methyl-N-((3S,4S)-4-methyl-1-nitrosopiperidin-3-yl)-7-nitroso-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-amine

VE0011036 N/A
N-methyl-N-((3S,4S)-4-methyl-1-nitrosopiperidin-3-yl)-7-nitroso-7H-pyrrolo[2,3-d]pyrimidin-4-amine Tofacitinib

N-methyl-N-((3S,4S)-4-methyl-1-nitrosopiperidin-3-yl)-7-nitroso-7H-pyrrolo[2,3-d]pyrimidin-4-amine

VE0011035 N/A
N-methyl-N-(3R,4R)-(4-methyl-1-nitrosopiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine Nicardipine

N-methyl-N-(3R,4R)-(4-methyl-1-nitrosopiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

VE009895 N/A
N-methyl-N-(4-methyl-1-nitrosopiperidin-3-yl)nitrous amide Tofacitinib

N-methyl-N-(4-methyl-1-nitrosopiperidin-3-yl)nitrous amide

VE0011040 N/A
N-methyl-N-(4-methylpiperidin-3-yl)nitrous amide Tofacitinib

N-methyl-N-(4-methylpiperidin-3-yl)nitrous amide

VE0011041 N/A
N-Methyl-N-Nitroso-o-toulidine Tofacitinib

N-Methyl-N-Nitroso-o-toulidine

VE0011030 10596-01-7
N-Nitroso Tofacitinib Tofacitinib

N-Nitroso Tofacitinib

VE009521 N/A
N-Nitroso Tofacitinib Impurity 2 Tofacitinib

N-Nitroso Tofacitinib Impurity 2

VE0011615 N/A
Budesonide for System Suitability CRS (Y0001148) Tofacitinib

N-Nitroso Tofacitinib Impurity 6

VE0017186 N/A
N,4-dimethyl-1-nitrosopiperidin-3-amine Tofacitinib

N,4-dimethyl-1-nitrosopiperidin-3-amine

VE0011039 N/A
N,7-dimethyl-N-((3S,4S)-4-methyl-1-nitrosopiperidin-3-yl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-amine Tofacitinib

N,7-dimethyl-N-((3S,4S)-4-methyl-1-nitrosopiperidin-3-yl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-amine

VE0011038 N/A
N,7-dimethyl-N-((3S,4S)-4-methyl-1-nitrosopiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine Tofacitinib

N,7-dimethyl-N-((3S,4S)-4-methyl-1-nitrosopiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

VE0011037 N/A
Tofacitinib (3R,4S)-Isomer Tofacitinib

Tofacitinib (3R,4S)-Isomer

VE0018269 1092578-46-5
Tofacitinib (3S,4R)-Isomer Tofacitinib

Tofacitinib (3S,4R)-Isomer

VE0018268 1092578-48-7
Tofacitinib Acid Impurity Tofacitinib

Tofacitinib Acid Impurity

VE008140 2328165-36-0
Tofacitinib Amide Impurity Tofacitinib

Tofacitinib Amide Impurity

VE008141 1675248-19-7
Tofacitinib Benzyl Impurity Tofacitinib

Tofacitinib Benzyl Impurity

VE006715 477600-73-0
Tofacitinib Citrate Diastereomer Tofacitinib

Tofacitinib Citrate Diastereomer

VE0010540 N/A
Tofacitinib Impurity 1 Tofacitinib

Tofacitinib Impurity 1

VE0018315 1812890-23-5
Tofacitinib Impurity 118 (HCl Salt) Tofacitinib

Tofacitinib Impurity 118 (HCl Salt)

VE0019701 N/A
Tofacitinib Impurity 119 Tofacitinib

Tofacitinib Impurity 119

VE0019703 N/A
Tofacitinib Impurity 24 Tofacitinib

Tofacitinib Impurity 24

VE0019880 134965-85-8
Tofacitinib Impurity 28 Tofacitinib

Tofacitinib Impurity 28

VE0018365 2227199-31-5
Tofacitinib Impurity 36 Tofacitinib

Tofacitinib Impurity 36

VE0018101 2250241-69-9
Tofacitinib Impurity 38 Tofacitinib

Tofacitinib Impurity 38

VE0017742 N/A
Tofacitinib Impurity 39 Tofacitinib

Tofacitinib Impurity 39

VE0017858 923036-30-0
Tofacitinib Impurity 42 Tofacitinib

Tofacitinib Impurity 42

VE0018109 90213-66-4
Tofacitinib Impurity 45 Tofacitinib

Tofacitinib Impurity 45

VE0010096 2407039-29-4
Tofacitinib Impurity 59 Tofacitinib

Tofacitinib Impurity 59

VE0018003 1616760-97-4
Tofacitinib Impurity 62 Citrate Tofacitinib

Tofacitinib Impurity 62 Citrate

VE008307 1092578-47-6
Tofacitinib Impurity 64 Tofacitinib

Tofacitinib Impurity 64

VE0018186 N/A
Tofacitinib Impurity 78 Tofacitinib

Tofacitinib Impurity 78

VE0010097 N/A
Tofacitinib Impurity C Citrate Tofacitinib

Tofacitinib Impurity C Citrate

VE006951 2174011-55-1
Tofacitinib Impurity V Tofacitinib

Tofacitinib Impurity V

VE0020319 1616761-00-2
Tofacitinib metabolite-1 Tofacitinib

Tofacitinib metabolite-1

VE0010102 1640971-51-2
Tofacitinib N-Descyanoacetyl Impurity Tofacitinib

Tofacitinib N-Descyanoacetyl Impurity

VE006714 477600-74-1
Tofacitinib N-Hydroxy Impurity Tofacitinib

Tofacitinib N-Hydroxy Impurity

VE0019699 N/A
Tofacitinib N-oxide impurity Tofacitinib

Tofacitinib N-oxide impurity

VE008142 2028267-73-2
Tofacitinib-D3 Citrate Tofacitinib

Tofacitinib-D3 Citrate

DVE001429 N/A
1,8-Diazabicyclo[5.4.0]undec-7-ene Tofacitinib

1,8-Diazabicyclo[5.4.0]undec-7-ene

VE008082 6674-22-2
3-((3R,4R)-4-Methyl-3-(methyl(5-oxo-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile Tofacitinib

3-((3R,4R)-4-Methyl-3-(methyl(5-oxo-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile

VE0010103 2101951-20-4
3-((3R,4S)-4-Methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile 2-hydroxypropane-1,2,3-tricarboxylate Tofacitinib

3-((3R,4S)-4-Methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile 2-hydroxypropane-1,2,3-tricarboxylate

VE0011626 2174011-53-9