Tryptophol is an aromatic alcohol that induces sleep in humans. It is found in wine as a secondary product of ethanol fermentation. It was first described by Felix Ehrlich in 1912. It is also produced by the trypanosomal parasite in sleeping sickness. It is also known by the IUPAC name 1H-indole-3-ethanol and has the molecular formula C10H11NO with a monoisotopic mass of 161.0849 Da and a nominal molecular weight of 161.20 g mol. Tryptophol contains an indole ring bonded to a two carbon alcohol side chain at the 3-position, is readily characterized by 1H and 13C NMR, GC-MS and LC-MS methods, and is routinely monitored in fermentation and biological matrices as a metabolic marker; typical handling calls for storage in a cool, dry place protected from strong oxidants.
Parent: Tryptophol / Etodolac
Parent: Tryptophol
Parent: Tryptophol
For research and analytical grade materials tryptophol is normally supplied at high purity, commonly 98 percent or greater by area on GC or by HPLC assay, with total related substances typically below 2 to 5 percent depending on grade; individual related compounds when present are often at trace to low percent levels. Common related compounds and impurities observed in fermentation or synthetic samples include indole, indole-3-acetic acid, indole-3-carbinol, tryptamine, skatole (3-methylindole) and other substituted indole ethanol isomers such as alkylated tryptophols; suppliers and quality control reports will list specification limits and typical impurity profiles, and confirmatory analysis is performed by GC-MS, LC-MS or NMR to quantify and identify related substances.
Tryptophol is primarily used as a research reagent and analytical standard in studies of fermentation chemistry, microbial metabolism, and neuropharmacology; it serves as a biomarker of yeast and bacterial ethanol metabolism, is studied for sedative and signaling effects in biological models, and is not an approved therapeutic product.
Tryptophol is sparingly soluble in water and is readily soluble in common organic solvents and alcohols such as ethanol, methanol, diethyl ether and chloroform; solubility will vary with temperature and solvent and should be confirmed experimentally for formulation work.
There is no single widely cited CAS number for 7-ethyl tryptophol in general reference sources; this specific positional ethyl derivative may not be broadly registered or may be listed under different supplier identifiers, so consult the supplier documentation or chemical registries for the exact CAS index used by a given provider.
1H-indole-3-ethanol is the systematic name for the compound commonly called tryptophol; the name describes an indole core with a two-carbon ethanol substituent at the 3-position and is used interchangeably in chemical literature and databases.
