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Tulathromycin Impurities

Tulathromycin is a macrolide antibiotic used in veterinary medicine to treat respiratory infections in livestock, particularly:
∙ Bovine respiratory disease (BRD) in cattle
∙ Swine respiratory disease (SRD) in pigs
It is sold under trade names like Draxxin, Tulissin, and others. Tulathromycin works by inhibiting bacterial protein synthesis via binding to the 50S ribosomal subunit, leading to bacterial death or growth inhibition.
It is known for its long-acting activity, allowing for single-dose treatment, which is highly practical in livestock care.

Structure

Product Name

CAS No.

Cat No.

Action

Tulathromycin A Diastereomer

Tulathromycin A Diastereomer

Parent: Tulathromycin / Azithromycin

CAS No.: 217500-34-0

Cat No.: VE0017042

Tulathromycin A Impurity 1

Parent: Tulathromycin

CAS No.: N/A

Cat No.: VE0017040

Tulathromycin A Impurity 12 (Diformate Salt)

Parent: Tulathromycin

CAS No.: N/A

Cat No.: VE0017095

Tulathromycin A Impurity 2

Parent: Tulathromycin

CAS No.: N/A

Cat No.: VE0017080

Tulathromycin A Impurity 3

Parent: Tulathromycin

CAS No.: N/A

Cat No.: VE0017082

Tulathromycin A Impurity 4

Parent: Tulathromycin

CAS No.: N/A

Cat No.: VE0017084

Tulathromycin A Impurity 5

Parent: Tulathromycin

CAS No.: N/A

Cat No.: VE0017087

Tulathromycin A Impurity 7

Parent: Tulathromycin

CAS No.: 2051579-09-8

Cat No.: VE0017090

Tulathromycin A Impurity 8

Parent: Tulathromycin

CAS No.: 2051579-12-3

Cat No.: VE0017093

Tulathromycin Acetone Condensate

Parent: Tulathromycin

CAS No.: N/A

Cat No.: VE0021279

Tulathromycin Formaldehyde Condensate

Parent: Tulathromycin

CAS No.: N/A

Cat No.: VE0021277

Tulathromycin Structural Isomer

Parent: Tulathromycin

CAS No.: 280755-12-6

Cat No.: VE0021278

Tulathromycin Related Compound

Impurities in tulathromycin can occur during synthesis, fermentation, or degradation, and must be controlled under veterinary pharmacopeia and regulatory standards to ensure product efficacy and animal safety.

Types of Impurities in Tulathromycin

Process-Related Impurities

Unreacted intermediates from macrolide ring synthesis
Fermentation by-products if biosynthetically produced
Residual solvents such as methanol or ethyl acetate

Degradation Impurities

Hydrolysis products in humid conditions
Oxidation products from exposure to light or air
Thermal degradation if not stored properly

Elemental Impurities

Trace levels of heavy metals (e.g., lead, mercury, arsenic) possibly introduced during manufacturing

Analytical Techniques for Impurity Detection

High-Performance Liquid Chromatography (HPLC)
Mass Spectrometry (MS)
Gas Chromatography (GC)
Fourier-Transform Infrared Spectroscopy (FT-IR)
Inductively Coupled Plasma (ICP) for elemental impurities

FAQ