|Parent Drug Name||Name of Impurity||Catalogue No.|
|Vigabatrin||Vigabatrin EP Impurity A||VL1590004||View CAS 7529-16-0|
|Vigabatrin||Vigabatrin EP Impurity B||VL1590007||View CAS 1379504-35-4|
|Vigabatrin||Vigabatrin EP Impurity C||VL1590002||View CAS 71107-19-2|
|Vigabatrin||Vigabatrin EP Impurity D||VL1590001||View CAS 56-12-2|
|Vigabatrin||Vigabatrin EP Impurity F||VL1590005||View CAS 794466-81-2|
|Vigabatrin||Vigabatrin Impurity 2||VL1590006||View|
|Vigabatrin||Vigabatrin N-carboxymethyl Vinylpyrrolidinone||VL1590003||View|
Vigabatrin Related Compound
Vigabatrin works by raising the level of gamma-aminobutyric acid in your brain (GABA). This stabilizes the electrical activity in your brain, which aids in preventing seizures.
- Ben-Menachem, E. “Mechanism of Action of Vigabatrin: Correcting Misperceptions.” Acta Neurologica Scandinavica, vol. 124, Nov. 2011, pp. 5–15, https://doi.org/10.1111/j.1600-0404.2011.01596.x. Accessed 2 Mar. 2023.
- “Vigabatrin: MedlinePlus Drug Information.” Medlineplus.gov, 2019, medlineplus.gov/druginfo/meds/a610016.html#:~:text=Vigabatrin%20is%20in%20a%20class,electrical%20activity%20in%20the%20brain. Accessed 2 Mar. 2023.
- Cruz, Martin P. “Vigabatrin (Sabril), a Gamma-Aminobutyric Acid Transaminase Inhibitor for the Treatment of Two Catastrophic Seizure Disorders.” Pharmacy and Therapeutics, vol. 35, no. 1, MediMedia USA, Inc., 2010, pp. 20–23, www.ncbi.nlm.nih.gov/pmc/articles/PMC2816152/#:~:text=A%20selective%2C%20irreversible%20enzyme%2Dactivated,and%20thus%20reduces%20seizure%20activity. Accessed 2 Mar. 2023.
What is the mechanism of action of vigabatrin?
Vigabatrin was rationally designed to have a specific effect on brain chemistry by blocking GABA transaminase, a GABA-degrading enzyme, resulting in a general rise in GABA concentrations in the brain. The increase in GABA acts as a brake on the excitatory processes that might cause seizures.
What type of drug is vigabatrin?
Vigabatrin belongs to the anticonvulsant drug class. It reduces aberrant electrical activity in the brain.
How does vigabatrin work as an epilepsy treatment?
Vigabatrin, an irreversible enzyme-activated GABA transaminase inhibitor, raises the amount of the inhibitory neurotransmitter GABA in the brain, reducing seizure activity.