Vigabatrin Impurities



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Parent Drug Name Name of Impurity Catalogue No.
Vigabatrin Vigabatrin EP Impurity A VL1590004View CAS 7529-16-0
Vigabatrin Vigabatrin EP Impurity B VL1590007View CAS 1379504-35-4
Vigabatrin Vigabatrin EP Impurity C VL1590002View CAS 71107-19-2
Vigabatrin Vigabatrin EP Impurity D VL1590001View CAS 56-12-2
Vigabatrin Vigabatrin EP Impurity F VL1590005View CAS 794466-81-2
Vigabatrin Vigabatrin Impurity 2 VL1590006View
Vigabatrin Vigabatrin N-carboxymethyl Vinylpyrrolidinone VL1590003View

Vigabatrin Related Compound

Vigabatrin works by raising the level of gamma-aminobutyric acid in your brain (GABA). This stabilizes the electrical activity in your brain, which aids in preventing seizures.


  • Ben-Menachem, E. “Mechanism of Action of Vigabatrin: Correcting Misperceptions.” Acta Neurologica Scandinavica, vol. 124, Nov. 2011, pp. 5–15, Accessed 2 Mar. 2023.
  • “Vigabatrin: MedlinePlus Drug Information.”, 2019,,electrical%20activity%20in%20the%20brain. Accessed 2 Mar. 2023.
  • Cruz, Martin P. “Vigabatrin (Sabril), a Gamma-Aminobutyric Acid Transaminase Inhibitor for the Treatment of Two Catastrophic Seizure Disorders.” Pharmacy and Therapeutics, vol. 35, no. 1, MediMedia USA, Inc., 2010, pp. 20–23,,and%20thus%20reduces%20seizure%20activity. Accessed 2 Mar. 2023. ‌


What is the mechanism of action of vigabatrin?

Vigabatrin was rationally designed to have a specific effect on brain chemistry by blocking GABA transaminase, a GABA-degrading enzyme, resulting in a general rise in GABA concentrations in the brain. The increase in GABA acts as a brake on the excitatory processes that might cause seizures.

What type of drug is vigabatrin?

Vigabatrin belongs to the anticonvulsant drug class. It reduces aberrant electrical activity in the brain.

How does vigabatrin work as an epilepsy treatment?

Vigabatrin, an irreversible enzyme-activated GABA transaminase inhibitor, raises the amount of the inhibitory neurotransmitter GABA in the brain, reducing seizure activity.