O ácido 4-cloro-3-sulfamoilbenzoico, CAS 1205-30-7, é uma impureza aromática do tipo sulfonamida benzoica, com fórmula C7H6ClNO4S e massa molecular de 235,64 g/mol. A disposição orto entre a função ácido carboxílico e a sulfamida, somada ao substituinte cloro em para, define um analito polar e fracamente ácido, relevante para o perfil de impurezas de processo e para estudos de degradação de intermediários sulfonamídicos clorados. Sua formação pode decorrer de sulfonação incompleta ou de controle inadequado da etapa de cloração durante a síntese. A quantificação em nível traço geralmente requer LC-MS/MS, LC-MS de alta resolução ou LC de par iônico com confirmação por UV, pois a HPLC convencional pode não separar adequadamente ácidos aromáticos estruturalmente correlatos.
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